Molecular basis of severe malaria

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 26, 2012, Pages 10130-10131

  Deitsch, Kirk W ^a   Chitnis, Chetan E ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN 4 SULFATE; INTERCELLULAR ADHESION MOLECULE 1; MALARIA VACCINE; RECOMBINANT DC13 ANTIBODY; RECOMBINANT DC8 ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

BRAIN MALARIA; CELL SURFACE; DISEASE COURSE; DISEASE SEVERITY; GEOGRAPHY; HUMAN; IMMUNITY; INFECTION PREVENTION; MALARIA; MALARIA FALCIPARUM; NONHUMAN; NOTE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DOMAIN; SEVERE MALARIA;

ANIMALS; BRAIN; CELL ADHESION; ENDOTHELIUM, VASCULAR; ERYTHROCYTES; GENES, PROTOZOAN; HUMANS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; PLASMODIUM; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 84862976182     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207174109     Document Type: Note

References (19)

1. Avril M, et al. (2012) A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells. Proc Natl Acad Sci USA 109:E1782-E1790.
2. Claessens A, et al. (2012) A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proc Natl Acad Sci USA 109:E1772-E1781.
3. Lavstsen T, et al. (2012) Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children. Proc Natl Acad Sci USA 109:E1791-E1800.
4. Miller LH, Baruch DI, Marsh K, Doumbo OK (2002) The pathogenic basis of malaria. Nature 415:673-679. (Pubitemid 34136400)
5. Baruch DI, et al. (1995) Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 82:77-87.
6. Smith JD, et al. (1995) Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82:101-110.
7. Su X, et al. (1995) A large and diverse gene family (var) encodes 200-350 kD proteins implicated in the antigenic variation and cytoadherence of Plasmodium falciparum-infected erythrocytes. Cell 82:89-100.
8. Kraemer SM, Smith JD (2006) A family affair: Var genes, PfEMP1 binding, and malaria disease. Curr Opin Microbiol 9:374-380. (Pubitemid 44108717)
9. Salanti A, et al. (2003) Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy- associated malaria. Mol Microbiol 49:179-191. (Pubitemid 36792013)
10. Salanti A, et al. (2004) Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J Exp Med 200:1197-1203. (Pubitemid 39507059)
11. Fried M, Duffy PE (1996) Plasmodium falciparum-infected erythrocytes adhere to chondroitin sulfate A in the human placenta. Science 272:1502-1504. (Pubitemid 26200005)
12. Staalsoe T, et al. (2004) Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet 363:283-289. (Pubitemid 38142411)
13. Ricke CH, et al. (2000) Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A. J Immunol 165: 3309-3316.
14. Barry AE, et al. (2007) Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathog 3:e34.
15. Kraemer SM, Smith JD (2003) Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family. Mol Microbiol 50:1527-1538. (Pubitemid 38010450)
16. Lavstsen T, Salanti A, Jensen ATR, Arnot DE, Theander TG (2003) Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Malar J 2:27.
17. Jensen ATR, et al. (2004) Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. J Exp Med 199:1179-1190. (Pubitemid 38620255)
18. RottmannM, et al. (2006) Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children. Infect Immun 74:3904-3911. (Pubitemid 43993322)
19. Rask TS, Hansen DA, Theander TG, Gorm PA, Lavstsen T (2010) Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes - Divide and conquer. PLOS Comput Biol 6((9)):e1000933.