BAI, a 3-aminoindazole derivative, inhibits interleukin-1β-induced expression of cyclooxygenase-2 in A549 human airway cells

International Journal of Molecular Medicine

Volumn 29, Issue 3, 2012, Pages 454-460

  Hong, Hua ^a   Park, Yu Kyoung ^a   Park, Jong Wook ^a   Lee, Jinho ^a   Hong, Ji Eun ^a   Park, Gy Young ^b   Jang, Byeong Churl ^a  

^a Keimyung University   (South Korea)

^b Catholic University of Daegu   (South Korea)

Author keywords

A549 cells; BAI; Cyclin dependent kinase; Cyclooxygenase 2; Histone H1; Interleukin 1

Indexed keywords

2 [(1,1' BIPHENYL) 4 YL] N [5 (1,1 DIOXO 1 LAMBDA 6 ISOTHIAZOLIDIN 2 YL) 1H INDAZOL 3 YL]ACETAMIDE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLOOXYGENASE 2; HISTONE H1; I KAPPA B ALPHA; INDAZOLE DERIVATIVE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CELL LINE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INDAZOLES; INTERLEUKIN-1BETA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN STABILITY; RNA STABILITY; SIGNAL TRANSDUCTION; THIAZOLIDINES;

EID: 84862975365     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.863     Document Type: Article

References (43)

1. Smith WL and Dewitt DL: Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 62: 167-215, 1996. (Pubitemid 26250630)
2. Smith WL, Garavito RM and DeWitt DL: Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271: 33157-33160, 1996. (Pubitemid 27010118)
3. Vane JR, Bakhle YS and Botting RM: Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38: 97-120, 1998. (Pubitemid 28231490)
4. Hla T, Ristimäki A, Appleby S and Barriocanal JG: Cyclo-oxygenase gene expression in inflammation and angiogenesis. Ann NY Acad Sci 696: 197-204, 1993. (Pubitemid 24062788)
5. Hla T, Bishop-Bailey D, Liu CH, Schaefers HJ and Trifan OC: Cyclooxygenase-1 and -2 isoenzymes. Int J Biochem Cell Biol 31: 551-557, 1999. (Pubitemid 29219401)
6. Williams GW: An update on nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors. Curr Pain Headache Rep 9: 377-389, 2005.
7. Herschman HR, Reddy ST and Xie W: Function and regulation of prostaglandin synthase-2. Adv Exp Med Biol 407: 61-66, 1997. (Pubitemid 27440707)
8. Inoue H, Yokoyama C, Hara S, Tone Y and Tanabe T: Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cell. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem 270: 24965-24971, 1995.
9. Newton R, Kuitert LM, Bergmann M, Adcock IM and Barnes PJ: Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem Biophys Res Commun 237: 28-32, 1997. (Pubitemid 27390317)
10. Ristimäki A, Garfinkel S, Wessendorf J, Maciag T and Hla T: Induction of cyclooxygenase-2 by interleukin-1alpha. Evidence for post-transcriptional regulation. J Biol Chem 269: 11769-11775, 1994.
11. Srivastava SK, Tetsuka T, Daphna-Iken D and Morrison AR: IL-1 beta stabilizes COX-2 mRNA in renal mesangial cells: role of 3′-untranslated region. Am J Physiol 267: 504-508, 1994.
12. Newton R, Stevens DA, Hart LA, Lindsay M, Adcock IM and Barnes PJ: Super-induction of COX-2 mRNA by cyclohexamide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation. FEBS Lett 418: 135-138, 1997. (Pubitemid 27514432)
13. Jang BC, Muñoz-Najar U, Paik JH, Claffey K, Yoshida M and Hla T: Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. J Biol Chem 278: 2773-2776, 2003. (Pubitemid 36801177)
14. Kang YJ, Mbonye UR, DeLong CJ, Wada M and Smith WL: Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation. Prog Lipid Res 46: 108-125, 2007. (Pubitemid 46661865)
15. Mbonye UR, Yuan C, Harris CE, et al: Two distinct pathways for cyclooxygenase-2 protein degradation. J Biol Chem 283: 8611-8623, 2008.
16. Hla T and Neilson K: Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89: 7384-7388, 1992.
17. Otto JC, DeWitt DL and Smith WL: N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and ther orientations in the endoplasmic reticulum. J Biol Chem 268: 18234-18242, 1993. (Pubitemid 23260348)
18. Nemeth JF, Hochgesang GP, Marnett LJ and Caprioli RM: Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometry. Biochemistry 40: 3109-3116, 2001. (Pubitemid 32205354)
19. Jang BC, Sung SH, Park JG, et al: Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. J Biol Chem 282: 27622-27632, 2007.
20. Jang BC, Sanchez T, Schaefers HJ, et al: Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. J Biol Chem 275: 39507-39515, 2000. (Pubitemid 32058977)
21. Chen W, Tang Q, Gonzales MS and Bowden GT: Role of p38 MAP kinases and ERK in mediation ultraviolet-B induced cyclooxygenase- 2 gene expression in human keratinocytes. Oncogene 20: 3921-3926, 2001. (Pubitemid 32646203)
22. Chen KH, Weng MS and Lin JK: Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochem Pharmacol 73: 215-227, 2007.
23. Hunot S, Vila M, Teismann P, et al: JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci USA 101: 665-670, 2004. (Pubitemid 38084694)
24. Jang BC: Induction of CO-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCS, Src, and glutathione depletion. Toxicol In Vitro 23: 120-126, 2009.
25. Lee J, Choi H, Kim KH, et al: Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18: 2292-2295, 2008. (Pubitemid 351447288)
26. Shin HC, Song DW, Baek WK, et al: Anticancer activity and differentially expressed genes in head and neck cancer cells treated with a novel cyclin-dependent kinase inhibitor. Chemotherapy 55: 353-362, 2009.
27. Soos TJ, Kiyokawa H, Yan JS, et al: Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ 7: 135-146, 1996. (Pubitemid 26049822)
28. Jiang YJ, Lu B, Choy PC and Hatch GM: Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNF alpha, LPS and M-CSF in human monocytes and macrophages. Mol Cell Biochem 246: 31-38, 2003. (Pubitemid 36798719)
29. Sung S, Park Y, Jo JR, et al: Overexpression of cyclooxygenase-2 in NCI-H292 human alveolar epithelial carcinoma cells: roles of p38 MAPK, ERK-1/2, and PI3K/PKB signaling proteins. J Cell Biochem 112: 3015-3024, 2011.
30. Ghosh S and Baltimore D: Activation of in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature 344: 678-682, 1990.
31. Thoma F, Koller T and Klug A: Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin. J Biol Chem 83: 403-427, 1979. (Pubitemid 10205723)
32. Thomas JO: Histone H1: location and role. Curr Opin Cell Biol 11: 312-317, 1999.
33. Wisniewski JR, Zougman A, Krüger S and Mann M: Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylation, methylation, and phosphorylation as well as differences between cell culture and tissue. Mol Cell Proteomics 6: 72-87, 2007. (Pubitemid 46152693)
34. Shen X and Gorovsky MA: Linker histone H1 regulates specific gene expression but not global transcription in vivo. Cell 86: 475-483, 1996. (Pubitemid 26272087)
35. Hellauer K, Sirard E and Turcotte B: Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276: 13587-13592, 2001.
36. Lu MJ, Mpoke SS, Dadd CA and Allis CD: Phosphorylated and dephosphorylated linker histone H1 reside in distinct chromatin domains in Tetrahymena macronuclei. Mol Biol Cell 6: 1077-1087, 1995.
37. Shen X, Yu L, Weir JW and Gorovsky MA: Linker histones are not essential and affect chromatin condensation in vivo. Cell 82: 47-56, 1995.
38. Roque A, Ponte I, Arrondo JL and Suau P: Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation. Nucleic Acids Res 36: 4719-4726, 2008.
39. Roth SY and Allis CD: Chromatin condensation: does histone H1 dephosphorylation play a role? Trends Biochem Sci 17: 93-98, 1992.
40. Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA and Herrera RE: The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation. Mol Cell Biol 23: 8626-8636, 2003. (Pubitemid 37433367)
41. Hale TK, Contreras A, Morrison AJ and Herrera RE: Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1alpha. Mol Cell 22: 693-699, 2006. (Pubitemid 43817599)
42. Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H and Saha D: The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells. Cancer Res 66: 1758-1766, 2006. (Pubitemid 43259961)
43. Antonysamy S, Hirst G, Park F, et al: Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett 19: 279-282, 2009.