High throughput enzyme inhibitor screening by functionalized magnetic carbonaceous microspheres and graphene oxide-based MALDI-TOF-MS

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 12, 2011, Pages 2188-2198

  Liu, Yang ^a   Li, Yan ^a   Liu, Junyan ^a   Deng, Chunhui ^a   Zhang, Xiangmin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Enzyme inhibitor screening; Functionalized magnetic carbonaceous microspheres; Graphene oxide; High throughput; MALDI

Indexed keywords

ACCURACY AND PRECISION; ACETYLCHOLINESTERASE; BIOCHEMICAL ASSAY; ENZYME INHIBITORS; FUNCTIONALIZED; GLYCIDOXYPROPYLTRIMETHOXYSILANE; HIGH THROUGHPUT; HIGH THROUGHPUT SCREENING; LIMIT OF DETECTION; MAGNETIC CARBONACEOUS MICROSPHERES; MALDI; MALDI TOF MS; MATRIX; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; MODEL SUBSTRATES; QUANTITATIVE DETERMINATIONS; STANDARD CURVES;

DESORPTION; ENZYME ACTIVITY; GRAPHENE; INDUCTIVELY COUPLED PLASMA; MASS SPECTROMETRY; MICROSPHERES; SILICON COMPOUNDS; THROUGHPUT;

MAGNETIC BUBBLES;

ACETYLCHOLINESTERASE; CARBON; CHOLINE; ENZYME INHIBITOR; GALANTAMINE; GRAPHENE; HUPERZINE A; HUPERZINE B; MICROSPHERE; TACRINE;

ACCURACY; ARTICLE; BIOASSAY; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ENZYME STABILITY; ENZYME SUBSTRATE; HIGH THROUGHPUT SCREENING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAGNETIC FIELD; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHASE SEPARATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO;

ACETYLCHOLINESTERASE; BIOSENSING TECHNIQUES; CHOLINESTERASE INHIBITORS; ENZYME ASSAYS; ENZYMES, IMMOBILIZED; GRAPHITE; HIGH-THROUGHPUT SCREENING ASSAYS; LIMIT OF DETECTION; LINEAR MODELS; MAGNETS; MICROSPHERES; OXIDES; REPRODUCIBILITY OF RESULTS; SILANES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84862974979     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0231-8     Document Type: Article

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