Robot-assisted automatic cell sorting with combined optical tweezer and microfluidic chip technologies

Proceedings - IEEE International Conference on Robotics and Automation

Volumn , Issue , 2011, Pages 6003-6008

  Wang, Xiaolin ^a   Chen, Shuxun ^a   Sun, Dong ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SORTER; CELL SORTING; FLOW ENVIRONMENT; FLUORESCENCE LABEL; IMAGE PROCESSING - METHODS; LASER POWER; LOW POWER; MICROFLUIDIC CHANNEL; MICROFLUIDIC CHIP; MOVING VELOCITY; ROBOTIC MANIPULATION; SMALL SAMPLES; TARGET CELLS; TRANSPORTATION EFFICIENCY; YEAST CELL;

CELLS; CYTOLOGY; FLUIDIC DEVICES; IMAGE PROCESSING; OPTICAL DATA PROCESSING; OPTICAL TWEEZERS; ROBOTICS;

MOLECULAR BIOLOGY;

EID: 84862971102     PISSN: 10504729     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ICRA.2011.5979662     Document Type: Conference Paper

References (19)

1. P. S. Dittrich, K. Tachikawa, and A. Manz, "Micro total analysis systems. Latest advancements and trends," Anal Chem, vol. 78, pp. 3887-3907, 2006.
2. Y. Tan, D. Sun, W. Huang, and S. Cheng, "Mechanical modeling of biological cells in microinjection," IEEE Trans. NanoBioSci, vol. 7, no. 4, pp. 257-266, 2008.
3. H. B. Huang, D. Sun, J. K. Mills, and S. H. Cheng, "Robotic cell injection system with vision and force control: Towards automatic batch biomanipulation," IEEE Trans. Robot., vol. 25, no. 3, pp. 727-737, 2009.
4. Y. Xie, D. Sun, C. Liu, H. Y. Tse, and S. H. Cheng, "A force control approach to a robot-assisted cell microinjection system," Int. J. Robot. Res., vol. 29, no. 3, 2010.
5. F. Arai, A. Ichikawa, M. Ogawa, T. Fukuda, K. Horio, and K. Itoogawa, "High-speed separation system of randomly suspended single living cells by laser trap and dielectrophoresis," Electrophoresis, vol. 22, pp. 283-288, 2001.
6. F. Arai, A. Kawaji, P. Luangjarmekorn, T. Fukuda, and K. Itoigawa, "Three-dimensional bio-manipulation under the microscope," Proc. IEEE Int. Conf. on Robotics and Automation, pp. 604-609, 2001.
7. Y. Wu, Y. Tan, D. Sun, and W. Huang, "Force analysis and path planning of the trapped cell in robotic cell manipulation by optical tweezers", IEEE Int. Conf. on Robotics and Automation, pp. 4119-4124, 2010.
8. Y. Wu, D. Sun, and W. Huang, "Mechanical force characterization in manipulating live cells with optical tweezers", Journal of Biomechanics, 2011(in press).
9. Y. Tan, D. Sun, J. Wang, and W. Huang, "Mechanical characterization of human red blood cells under different osmotic conditions by robotic manipulation with optical tweezers," IEEE Trans. Biomed. Eng., vol. 57, no. 7, pp. 1816-1825, 2010.
10. A. Ashkin, "Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime," Biophys. J., vol. 61, pp. 569-582, 1992.
11. C. C. Lin, A. Chen, and C. H. Lin, "Microfluidic cell counter/sorter utilizing multiple particle tracing technique and optically switching approach," Biomed Microdevices, vol. 10, pp. 55-63, 2008.
12. M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. C. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nature Biotechnology, vol. 23, pp. 83-87, 2005.
13. T. D. Perroud, J. N. Kaiser, J. C. Sy, T. W. Lane, C. S. Branda, A. K. Singh, and K. D. Patel, "Microfluidic-based cell sorting of francisella tularensis infected macrophages using optical forces," Anal. Chem., vol. 80, pp. 6365-6372, 2008.
14. Y. Xia, and G. M. Whitesides, "Soft Lithography," Annu. Rev. Mater. Sci, vol. 28, pp. 153-184, 1998.
15. E Eriksson, J Scrimgeour, A Graneli, K Ramser, R Wellander, J Enger, D Hanstorp, and M Goksor, "Optical manipulation and microfluidics for studies of single cell dynamics", J. Opt. A: Pure Appl. Opt, vol. 9, pp. S113-S121, 2007.
16. J.R. Weaver and J.L. Au, "Application of automatic thresholding in image analysis scoring of cells in human solid tumors labeled for proliferation markers," Cytometry, vol. 29, pp. 128-136, 1997.
17. M. B, S. M. Block, and K. Svoboda, "Biological applications of optical forces," Annu.Rev.Biophys.Biomol.Struct, vol. 23, pp. 247-285, 1994.
18. E. Eriksson, S. Keen, J. Leach, M. Goksör and M. Padgett, "The effect of external forces on discrete motion within holographic optical tweezers," Optics Express, vol. 15, pp. 18268-18274, 2007.
19. W. H. Wright, G. J. Sonek, and M. W. Berns, "Parametric study of the forces on microspheres held by optical tweezers," Appl. Opt., vol. 33, pp. 1735-1748, 1994.