High levels of remnant lipoprotein cholesterol is a risk factor for large artery atherosclerotic stroke

Journal of Clinical Neurology (Korea)

Volumn 7, Issue 4, 2011, Pages 203-209

  Kim, Jeong Yeon ^a   Park, Jong Ho ^b   Jeong, Sang Wuk ^a   Schellingerhout, Dawid ^c   Park, Jin Eok ^a   Lee, Dong Kun ^a   Choi, Won Jun ^a   Chae, Seok Lae ^a   Kim, Dong Eog ^a  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Catholic Kwandong University   (South Korea)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Ischemic stroke; Large artery atherosclerosis; Remnant lipoprotein cholesterol

Indexed keywords

EID: 84862959632     PISSN: 17386586     EISSN: 20055013     Source Type: Journal    
DOI: 10.3988/jcn.2011.7.4.203     Document Type: Article

References (25)

1. Gotto AM Jr. Evolving concepts of dyslipidemia, atherosclerosis, and cardiovascular disease: the Louis F. Bishop Lecture. J Am Coll Cardiol 2005;46:1219-1224.
2. Illingworth DR, Durrington PN. Dyslipidemia and atherosclerosis: how much more evidence do we need? Curr Opin Lipidol 1999;10:383-386.
3. Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol 2009;8:453-463.
4. Devaraj S, Vega G, Lange R, Grundy SM, Jialal I. Remnant-like particle cholesterol levels in patients with dysbetalipoproteinemia or coronary artery disease. Am J Med 1998;104:445-450.
5. Karpe F, Taskinen MR, Nieminen MS, Frick MH, Kesäniemi YA, Pasternack A, et al. Remnant-like lipoprotein particle cholesterol concentration and progression of coronary and vein-graft atherosclerosis in response to gemfibrozil treatment. Atherosclerosis 2001;157:181-187.
6. Jialal I, Devaraj S. Remnant lipoproteins: measurement and clinical significance. Clin Chem 2002;48:217-219.
7. Krauss RM. Atherogenicity of triglyceride-rich lipoproteins. Am J Cardiol 1998;81:13B-17B.
8. Hodis HN. Triglyceride-rich lipoprotein remnant particles and risk of atherosclerosis. Circulation 1999;99:2852-2854.
9. Cohn JS, Marcoux C, Davignon J. Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins. Arterioscler Thromb Vasc Biol 1999;19:2474-2486.
10. Karpe F, Boquist S, Tang R, Bond GM, de Faire U, Hamsten A. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J Lipid Res 2001;42:17-21.
11. McNamara JR, Shah PK, Nakajima K, Cupples LA, Wilson PW, Ordovas JM, et al. Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study. Atherosclerosis 2001;154:229-236.
12. Kugiyama K, Doi H, Takazoe K, Kawano H, Soejima H, Mizuno Y, et al. Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease. Circulation 1999;99:2858-2860.
13. Tanaka A. Postprandial hyperlipidemia and atherosclerosis. J Atheroscler Thromb 2004;11:322-329.
14. Nakamura T, Obata JE, Takano H, Kawabata K, Sano K, Kobayashi T, et al. High serum levels of remnant lipoproteins predict ischemic stroke in patients with metabolic syndrome and mild carotid atherosclerosis. Atherosclerosis 2009;202:234-240.
15. Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. Classification of stroke subtypes. Cerebrovasc Dis 2009;27:493-501.
16. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41.
17. Nakajima K, Okazaki M, Tanaka A, Pullinger CR, Wang T, Nakano T, et al. Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B-100 and apo A-I. J Clin Ligand Assay 1997;19:177-183.
18. Kugiyama K, Doi H, Motoyama T, Soejima H, Misumi K, Kawano H, et al. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 1998;97:2519-2526.
19. Doi H, Kugiyama K, Oka H, Sugiyama S, Ogata N, Koide SI, et al. Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation 2000; 102:670-676.
20. Griendling KK, Alexander RW. Endothelial control of the cardiovascular system: recent advances. FASEB J 1996;10:283-292.
21. Fukushima H, Sugiyama S, Honda O, Koide S, Nakamura S, Sakamoto T, et al. Prognostic value of remnant-like lipoprotein particle levels in patients with coronary artery disease and type II diabetes mellitus. J Am Coll Cardiol 2004;43:2219-2224.
22. Satoh A, Adachi H, Tsuruta M, Hirai Y, Hiratsuka A, Enomoto M, et al. High plasma level of remnant-like particle cholesterol in the metabolic syndrome. Diabetes Care 2005;28:2514-2518.
23. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991; 251:788-791.
24. Kim DE, Kim JY, Schellingerhout D, Kim EJ, Kim HK, Lee S, et al. Protease imaging of human atheromata captures molecular information of atherosclerosis, complementing anatomic imaging. Arterioscler Thromb Vasc Biol 2010;30:449-456.
25. Ellsworth JL, Kraemer FB, Cooper AD. Transport of beta-very low density lipoproteins and chylomicron remnants by macrophages is mediated by the low density lipoprotein receptor pathway. J Biol Chem 1987; 262:2316-2325.