Construction and functional activity of a recombinant vector expressing rat glutamic acid decarboxylase 65

Neuroscience Bulletin

Volumn 27, Issue 6, 2011, Pages 430-435

  Liu, Jian Sheng ^a   Wang, Qian ^a   Zhang, Ji Bo ^a   Kong, Ling Ju ^a   Yao, Su Yan ^a   Zheng, De Yu ^a   Xu, Qun Yuan ^b  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Gene clone; Lentivirus vector; Parkinson's disease; Rat glutamic acid decarboxylase 2

Indexed keywords

4 AMINOBUTYRIC ACID; COMPLEMENTARY DNA; GLUTAMATE DECARBOXYLASE 65; LENTIVIRUS VECTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE AMPLIFICATION; GENE FUNCTION; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOTACTIC PROCEDURE; SUBSTANTIA NIGRA PARS RETICULATA; SUBTHALAMIC NUCLEUS; WESTERN BLOTTING;

ANIMALS; CLONING, MOLECULAR; GENETIC VECTORS; GLUTAMATE DECARBOXYLASE; GREEN FLUORESCENT PROTEINS; LENTIVIRUS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TRANSFECTION;

EID: 84862953339     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-011-1840-8     Document Type: Article

References (9)

1. Ehringer H, Hornykiewicz O. Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system. Klin Wochenschr 1960, 38: 1236-1239.
2. Beal MF. Experimental models of Parkinson's disease. Nat Rev Neurosci 2001, 2(5): 325-334.
3. Siderowf A, Stern M. Update on Parkinson disease. Ann Intern Med 2003, 138(8): 651-658. (Pubitemid 38124657)
4. Gross CE, Boraud T, Guehl D, Bioulac B, Bezard E. From experimentation to the surgical treatment of Parkinson's disease: prelude or suite in basal ganglia research? Prog Neurobiol 1999, 59(5): 509-532. (Pubitemid 29392969)
5. Boraud T, Bezard E, Bioulac B, Gross CE. From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control. Prog Neurobiol 2002, 66(4): 265-283. (Pubitemid 34311840)
6. Mandel RJ, Snyder RO, Leff SE. Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease. Exp Neurol 1999, 160(1): 205-214.
7. Robbins PD, Tahara H, Ghivizzani SC. Viral vectors for gene therapy. Trends Biotechnol 1998, 16: 35-40. (Pubitemid 28064816)
8. Kirik D, Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel RJ, et al. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-DOPA using rAAVmediated gene transfer. Proc Natl Acad Sci U S A 2002, 99(7): 4708-4713. (Pubitemid 34286049)
9. Luo J, Kaplitt MG, Fitzsimons HL, Zuzga DS, Liu Y, Oshinsky ML, et al. Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science 2002, 298(5592): 425-429. (Pubitemid 35176353)