The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 1, 2012, Pages 33-38

  Hoshino, Yu ^a   Koide, Hiroyuki ^b   Furuya, Keiichi ^c   Haberaecker III, Walter W ^b   Lee, Shih Hui ^b   Kodama, Takashi ^d   Kanazawa, Hiroaki ^c   Oku, Naoto ^c   Shea, Kenneth J ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SHIZUOKA   (Japan)

^d Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDOTE; CARBON 14; MELITTIN; MONOMER; NANOPARTICLE; PEPTIDE; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NANOTECHNOLOGY; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; SYNTHESIS; TISSUE DISTRIBUTION;

ACRYLAMIDES; ACRYLATES; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL DEATH; CELL LINE, TUMOR; HUMANS; MELITTEN; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED BALB C; NANOPARTICLES; NEUTRALIZATION TESTS; PARTICLE SIZE; POLYMERS; PROTEIN BINDING; TISSUE DISTRIBUTION;

EID: 84862945293     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112828109     Document Type: Article

References (32)

1. Haag R, Kratz F (2006) Polymer therapeutics: concepts and applications. Angew Chem Int Ed 45:1198-1215. (Pubitemid 44097641)
2. Schmidt M, Pei L (2011) Synthetic toxicology: Where engineering meets biology and toxicology. Toxicol Sci 120(suppl 1):S204-S224.
3. Hoshino Y, et al. (2010) Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: A plastic antibody. J Am Chem Soc 132:6644-6645.
4. Leroux J-C (2007) Injectable nanocarriers for biodetoxification. Nat Nano 2:679-684.
5. Oya T, et al. (1999) Reversible molecular adsorption based on multiple-point interaction by shrinkable gels. Science 286:1543-1545.
6. Hoshino Y, et al. (2009) Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. Small 5:1562-1568.
7. De M, You C-C, Srivastava S, Rotello VM (2007) Biomimetic interactions of proteins with functionalized nanoparticles: A thermodynamic study. J Am Chem Soc 129:10747-10753. (Pubitemid 350067485)
8. Dernedde J, et al. (2010) Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation. Proc Natl Acad Sci USA 107:19679-19684.
9. Koch SJ, Renner C, Xie X, Schrader T (2006) Tuning linear copolymers into protein-specific hosts. Angew Chem Int Ed 45:6352-6355. (Pubitemid 44483863)
10. Cabaleiro-Lago C, et al. (2008) Inhibition of amyloid β protein fibrillation by polymeric nanoparticles. J Am Chem Soc 130:15437-15443.
11. Tabata Y, Ikada Y (1988) Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage. Biomaterials 9:356-362.
12. Sun X, et al. (2005) An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules 6:2541-2554. (Pubitemid 41388265)
13. Owens Iii DE, Peppas NA (2006) Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 307:93-102.
14. Alexis F, Pridgen E, Molnar LK, Farokhzad OC (2008) Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5:505-515.
15. Cedervall T, et al. (2007) Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc Natl Acad Sci USA 104:2050-2055. (Pubitemid 46391350)
16. Gan D, Lyon LA (2002) Synthesis and protein adsorption resistance of PEG-modified poly(N-isopropylacrylamide) core/shell microgels. Macromolecules 35:9634-9639.
17. Dobrovolskaia MA, Germolec DR, Weaver JL (2009) Evaluation of nanoparticle immunotoxicity. Nat Nano 4:411-414.
18. Nel AE, et al. (2009) Understanding biophysicochemical interactions at the nanobio interface. Nat Mater 8:543-557.
19. Hoshino Y, Kodama T, Okahata Y, Shea KJ (2008) Peptide imprinted polymer nanoparticles: A plastic antibody. J Am Chem Soc 130:15242-15243.
20. Hoshino Y, et al. (2010) Affinity purification of multifunctional polymer nanoparticles. J Am Chem Soc 132:13648-13650.
21. Habermann E (1972) Bee and wasp venoms. Science 177:314-322.
22. Wang R, et al. (2007) Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 13:1510-1514. (Pubitemid 350224240)
23. Wardenburg JB, Bae T, Otto M, DeLeo FR, Schneewind O (2007) Poring over pores: [alpha]-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 13:1405-1406. (Pubitemid 350224232)
24. Gold BS, Dart RC, Barish RA (2002) Bites of venomous snakes. N Engl J Med 347:347-356.
25. Torres AM, Kuchel PW (2004) The β-defensin-fold family of polypeptides. Toxicon 44:581-588.
26. Nishino H, Huang C-S, Shea KJ (2006) Selective protein capture by epitope imprinting. Angew Chem Int Ed 45:2392-2396.
27. Li Y, Yang H-H, You Q-H, Zhuang Z-X, Wang X-R (2006) Protein recognition via surface molecularly imprinted polymer nanowires. Anal Chem 78:317-320. (Pubitemid 43050169)
28. Voet D, Voet JG (1995) Biochemistry (Wiley, New York).
29. Zeng Z, Hoshino Y, Rodriguez A, Yoo H, Shea KJ (2010) Synthetic polymer nanoparticles with antibody-like affinity for a hydrophilic peptide. ACS Nano 4:199-204.
30. Epand RM, Shai Y, Segrest JP, Anantharamiah GM (1995) Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides. Biopolymers 37:319-338.
31. White SH, Wimley WC (1999) Membrane protein folding and stability: Physical principles. Annu Rev Biophys Biomol Struct 28:319-365. (Pubitemid 29319262)
32. Hoshino Y, Kawasaki T, Okahata Y (2006) Effect of ultrasound on DNA polymerase reactions: Monitoring on a 27-MHz quartz crystal microbalance. Biomacromolecules 7:682-685.