Inhibition of 2-aminofluorene and 4-nitro-o-phenylenediamine mutagenicity by natural food colorant plant Rubia cordifolia L

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue 1, 2012, Pages 236-237

  Chandel, Madhu ^a   Kumar, Manish ^a   Kumar, Subodh ^a   Kaur, Satwinderjeet ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

Author keywords

2 aminofluorene; 4 nitro o phenylenediamine; Antimutagenic activity; Rubia cordifolia L. mutagenicity

Indexed keywords

2 FLUORENYLAMINE; 4 NITRO 1,2 PHENYLENEDIAMINE; ANTIMUTAGENIC AGENT; HISTIDINE; PLANT EXTRACT; RUBIA CORDIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG SYNTHESIS; IC 50; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PLANT ROOT; RUBIA CORDIFOLIA; SALMONELLA TYPHIMURIUM;

EID: 84862943045     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Cuzzocrrea S, Riley PD, Caputi PA, Salvemini D. Antioxidant therapy: a newpharmacological approach in shock, inflammation, and ischemia/reper fusion injury. Pharmacol. Rev 2001; 53: 135-159.
2. Migliore L, Coppede F. Genetics and Environmental factors in cancer and neurodegenerative diseases. Mutat Res 2002; 512: 35-153
3. Zahin M, Ahmad I, Aqil F. Antioxidant and antimutagenic activity of Carum copticum fruits extracts. Toxicology in Vitro 2010; 24: 1243-1249
4. Ferguson LR. Antimutagens as cancer chemopreventive agents in the diet. Mutat Res 1994; 307: 395-410.
5. Edenharder R, Sager WJ, Glatt H, Mucket E, Platt LK. Protection by beverages, fruits, vegetables, herbs and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in metabolically competent V79 cells. Mutat Res 2002; 521: 57-72
6. Ikuma NEM, Passoni HM, Biso IF, Longo CM, Cardoso PRC, Campaner SL, Varanda AE. Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium. Toxicol. In Vitro 2006; 20: 361-366
7. Jeong TJ, Moon JH, Park KH, Shin S. Isolation and characterization of a new compound from Prunus mume fruit that inhibits cancer cells. J Agric Food Chem 2006; 54: 2123-2128
8. De Flora, S. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat. Res. 1998; 402: 151-158
9. De Flora S, Ramel C. Mechanisms of inhibitors of mutagenesis and carcinogenesis: classification and overview. Mutat Res 1988; 202: 285-306
10. Goldstein JA, Faletto MB. Advances in mechanisms of activation and deactivation of environmental chemicals. Environ. Health Perspect 1993; 100: 169-176
11. Kohlmeir L, Simonsen N, Mottus K. Dietary modifiers of carcinogenesis. Env Health 1995; 103: 177-184
12. Lee NJ, choi JH, Koo BS, Ryu SY, Han YH, Lee SI, Lee DU. Antimutagenicity and cytotoxicity of the constituents from the aereal parts of Rumex acetosa. Biol Pharm Bull 2005; 28: 2158-2161
13. Reid KA, Maes J, Maes A, Van Staden J, De Kimpe N, Mulholland DA, Verschaeve L. Evaluation of the mutagenic and antimutagenic effects of South African plants. J Ethnopharmacol 2006; 106: 44-50
14. Gonzalez-Avila M, Arriaga-Alba M, de la Garza M, Hernandez-pretelin MC, Dominguez-Ortiz MA, Fattel-Fazenda S, Villa-Trevino S. Antigenotoxic, antimutagnic and ROS scavenging activities of Rhoeo discolor ethanolic crude extract. Toxicol In Vitro 2003; 17: 77-83
15. Reyes-Lopez M, Villa-Trevino S, Arriaga-alba M, Aleman-Lazarini L, Rodriguez-Mendiola M, Arias-Castro C, Fattel-Fazenda S, de la Garza M. The amoebicidal aqueous extract from Castela texana possesses antigenotoxic and antimutagenic properties. Toxicol In Vitro 2005; 19: 91-97
16. Son JK, Jung SJ, Jung JH, Fang Z, Lee CS, Seo CS et al. Anticancer constituents from the roots of Rubia cordifolia L. Chem Pharm Bull 2005; 56: 213-216
17. Gao XM, Xu ZM, Li ZW. Traditional Medicine. Beijing: People's in Health Publishing House, 2000.
18. Maron D, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983; 113: 173-215
19. Grover IS, Bala, S. Studies on antimuatgenicity of myroblan (Terminalia bellerica vern. Behera) in S. typhimurium. Proc. Natl. Acad. Sci. India. 1993; 63: 425-432
20. Anderson S. Factors that contribute to biomarker responses in humans including a study in individuals taking vitamin C supplementation. Mutat Res 2001; 480: 337-347
21. Nair PC, Sobhia ME. Comparative QSTR studies for predicting mutagenicity of nitro compounds. J Mol Graph model 2008; 26: 916-934
22. Mazzatorta P, Tran LA, Schilfer B, Grigorov M. Integration of structure-activity relationship and artificial intelligence systems to improve in silica prediction of Ames test mutagenicity. J Chem Inf Model 2007; 47: 34-38
23. Waters MD, Stack HF, Brady AL, Lohman PHM, Haroun L, Vainio H. Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds. Mutat Res 1988;205:295-312
24. Muller HJ. Artificial transmutation of the gene. Science 1927; 66: 84-87
25. Brockman HE, DeMarini DM. Utility of short-term tests for genetic toxicity in the aftermath of the NTP's analysis of 73 chemicals. Environ. Mol. Mutagen. 1988; 11: 421-435
26. Ashby J. Are short term genetic tests useful for predicting carcinogenicity? A panel discussion revisited. Env. Mol. Mutagen. 1990; 16: 324-327
27. Novic A, Szilard L. Antimutagens. Nature 1952; 170: 926-927
28. Takahashi E, Marczylo TH, Watanable T, Nagai S, Hayatsu H, Negishi T. Preventive effects of anthraquinone food pigments on the DNA damage induced by carcinogens in Drosophilla. Mutat Res 2001; 481: 139-145
29. Kaur K, Arora S, Kumar S, Nagpal A. Modulatory effects of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay. J Environ Pathol Toxicol Oncol 2002; 21: 45-56
30. Kaur P, Singh B, Kumar S, Kaur S. In vitro evaluation of free radical scavenging activity of Rubia cordifolia L. J Chin Clin Med 2008; 5: 278-284
31. Kaur P, Chandel M, Kumar S, Kumar N, Singh B, Kaur S. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food Chem Toxicol 2010; 48: 320-325.
32. Cai Y, Sun M, Xing J, Corke H. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. J. Agric. Food Chem. 2004; 52: 7884-7890
33. Patel P R, Nagar A A, Patel R C, Rathod D K, Patel V R. Invitro anticancer activity of Rubia cordifolia against hela and hep2 cell lines. Int J Pharm Pharm Sci. 2011; 3; 70-71.
34. Phapale R, Thakur S M. Antioxidant activity and antimutagenic effect of phenolic compounds in Feronia limonia (L.) Swingle fruit. Int J Pharm Pharm Sci. 2010; 2; 68-73