Effects of supplemental erythropoietin on its receptor expression and signal transduction pathways in rat model of retinal detachment

Current Eye Research

Volumn 37, Issue 2, 2012, Pages 138-144

  Xie, Zhenggao ^a,b   Chen, Fang ^a   Wu, Xingwei ^b   Zhuang, Chaorong ^a   Zhu, Jun ^a   Wang, Jian ^a   Ji, Heqing ^a   Wang, Yakun ^a   Hua, Xin ^a  

^a YANGZHOU UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Erythropoietin; Erythropoietin receptor; Retinal detachment; Signal transduction pathway

Indexed keywords

ERYTHROPOIETIN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN; STAT5 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RETINA DETACHMENT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SUPPLEMENTATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; JANUS KINASE 2; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ERYTHROPOIETIN; RETINAL DETACHMENT; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84862934101     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2011.647225     Document Type: Article

References (37)

1. Jelkmann W, Metzen E. Erythropoietin in the control of red cell production. Ann Anat. 1996;178:391-403. (Pubitemid 26364568)
2. Rex TS, Allocca M, Domenici L et al. Systemic but not intraocular EPO gene transfer protects the retina from light-and genetic-induced degeneration. Mol Ther. 2004;10:855-861. (Pubitemid 39419912)
3. Grimm C, Wenzel A, Stanescu D et al. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci. 2004;24:5651-5658. (Pubitemid 38857219)
4. Grimm C, Wenzel A, Groszer M et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med. 2002;8:718-724. (Pubitemid 34778725)
5. Rex TS, Wong Y, Kodali K, Merry S. Neuroprotection of photoreceptors by direct delivery of erythropoietin to the retina of the retinal degeneration slow mouse. Exp Eye Res. 2009;89:735-740.
6. Junk AK, Mammis A, Savitz SI et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA. 2002;99:10659-10664.
7. Fu QL, Wu W, Wang H, Li X, Lee VW, So KF. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Cell Mol Neurobiol. 2008;28:317-329. (Pubitemid 351253068)
8. Tsai JC, Wu L, Worgul B, Forbes M, Cao J. Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma. Curr Eye Res. 2005;30:1025-1031. (Pubitemid 43154696)
9. Tsai JC, Song BJ, Wu L, Forbes M. Erythropoietin: A candidate neuroprotective agent in the treatment of glaucoma. J Glaucoma. 2007;16:567-571. (Pubitemid 47415215)
10. Weishaupt JH, Rohde G, Pölking E, Siren AL, Ehrenreich H, Bähr M. Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells. Invest Ophthalmol Vis Sci. 2004;45:1514-1522. (Pubitemid 38859333)
11. Kilic U, Kilic E, Soliz J, Bassetti CI, Gassmann M, Hermann DM. Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J. 2005;19:249-251. (Pubitemid 40189271)
12. King CE, Rodger J, Bartlett C, Esmaili T, Dunlop SA, Beazley LD. Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection. Exp Neurol. 2007;205:48-55. (Pubitemid 46617489)
13. Sättler MB, Merkler D, Maier K et al. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell Death Differ. 2004;11:S181-S192.
14. Diem R, Sättler MB, Merkler D et al. Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain. 2005;128:375-385. (Pubitemid 40222606)
15. Zhu B, Wang W, Gu Q, Xu X. Erythropoietin protects retinal neurons and glial cells in early-stage streptozotocin-induced diabetic rats. Exp Eye Res. 2008;86:375-382.
16. Zhang J, Wu Y, Jin Y et al. Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes. Invest Ophthalmol Vis Sci. 2008;49:732-742.
17. Shen J, Wu Y, Xu JY et al. ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Invest Ophthalmol Vis Sci. 2010;51:35-46.
18. Wang Q, Pfister F, Dorn-Beineke A et al. Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina. Diabetologia. 2010;53:1227-1238.
19. Li W, Sinclair SH, Xu GT. Effects of intravitreal erythropoietin therapy for patients with chronic and progressive diabetic macular edema. Ophthalmic Surg Lasers Imaging. 2010;41:18-25.
20. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008;118:526-533. (Pubitemid 351206543)
21. Patel S, Rowe MJ, Winters SA, Ohls RK. Elevated erythropoietin mRNA and protein concentrations in the developing human eye. Pediatr Res. 2008;63:394-397. (Pubitemid 351450585)
22. Chung H, Lee H, Lamoke F, Hrushesky WJ, Wood PA, Jahng WJ. Neuroprotective role of erythropoietin by antiapoptosis in the retina. J Neurosci Res. 2009;87:2365-2374.
23. Cai Z, Manalo DJ, Wei G et al. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 2003; 108:79-85. (Pubitemid 36859024)
24. Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between JAK2 and NF-kappaB signalling cascades. Nature. 2001;412:641-647. (Pubitemid 32772276)
25. Fandrey J, Jelkmann WE. Interleukin-1 and tumor necrosis factor-alpha inhibit erythropoietin production in vitro. Ann N Y Acad Sci. 1991;628:250-255.
26. Semenza GL. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 2001;107:1-3. (Pubitemid 32972030)
27. Ghezzi P, Brines M. Erythropoietin as an anti-apoptotic, tissue- protective cytokine. Cell Death Differ. 2004;11:S37-S44. (Pubitemid 39136797)
28. Anderson DH, Guérin CJ, Erickson PA, Stern WH, Fisher SK. Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci. 1986;27:168-183. (Pubitemid 16129783)
29. Xie Z, Wu X, Qiu Q et al. Expression pattern of erythropoietin and erythropoietin receptor in experimental model of retinal detachment. Curr Eye Res. 2007;32:757-764. (Pubitemid 47450627)
30. Zacks DN, Hänninen V, Pantcheva M, Ezra E, Grosskreutz C, Miller JW. Caspase activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2003;44:1262-1267. (Pubitemid 36297848)
31. Elliott S, Busse L, Bass MB et al. Anti-EPO receptor antibodies do not predict EPO receptor expression. Blood. 2006;107:1892-1895. (Pubitemid 43289368)
32. Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN,Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelialcells. Blood. 2004;104:2073-2080. (Pubitemid 39297859)
33. Wang S, Linsenmeier RA. Hyperoxia improves oxygen consumption in the detached feline retina. Invest Ophthalmol Vis Sci. 2007;48:1335-1341. (Pubitemid 351261432)
34. Chong ZZ, Lin SH, Kang JQ, Maiese K. Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res. 2003;71:659-669. (Pubitemid 36255350)
35. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37-40. (Pubitemid 32225829)
36. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in STAT5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001;98:3261-3273.
37. Genc S, Koroglu TF, Genc K. Erythropoietin and the nervous system. Brain Res. 2004;1000:19-31. (Pubitemid 38446486)