Macrophage migration inhibitory factor isolated from a parasite inhibited Th2 cytokine production in PBMCs of atopic asthma patients

Journal of Asthma

Volumn 49, Issue 1, 2012, Pages 10-15

  Park, Hye Kyung ^a,b   Cho, Min Kyoung ^a   Park, Hee Young ^b   Kim, Ki Uk ^a,b   Kim, Yun Seong ^a,b   Lee, Min Ki ^a,b   Park, Soon Kew ^a   Kim, Dong Hee ^c   Yu, Hak Sun ^a,b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

asthma; macrophage migration inhibitory factor (MIF); parasite; Th2 cytokines

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; RECOMBINANT MACROPHAGE MIGRATION INHIBITORY FACTOR; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; PARASITE; PERIPHERAL BLOOD MONONUCLEAR CELL; TH1 CELL; TH2 CELL;

ADULT; ANIMALS; ASTHMA; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HELMINTHS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MIDDLE AGED; TH2 CELLS; YOUNG ADULT;

EID: 84862922609     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2011.637593     Document Type: Article

References (22)

1. Lynch NR, Hagel I, Perez M, Di Prisco MC, Lopez R, Alvarez N. Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum. J Allergy Clin Immunol 1993; 92:404-411. (Pubitemid 24088692)
2. Lynch NR, Hagel IA, Palenque ME, Di Prisco MC, Escudero JE, Corao LA, Sandia JA, Ferreira LJ, Botto C, Perez M, Le Souef PN. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 1998; 101:217-221. (Pubitemid 28152384)
3. Araujo MI, Lopes AA, Medeiros M, Cruz AA, Sousa-Atta L, Sole D, Carvalho EM. Inverse association between skin response to aeroallergens and Schistosoma mansoni infection. Int Arch Allergy Immunol 2000; 123:145-148.
4. Dagoye D, Bekele Z, Woldemichael K, Nida H, Yimam M, Hall A, Venn AJ, Britton JR, Hubbard R, Lewis SA. Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Am J Respir Crit Care Med 2003; 167:1369-1373. (Pubitemid 36609721)
5. van den Biggelaar AH, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YC, Souverijn JH, Missinou MA, Borrmann S, Kremsner PG, Yazdanbakhsh M. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 2004; 189:892-900. (Pubitemid 38328191)
6. Geiger SM, Caldas IR,Mc Glone BE, Campi-Azevedo AC, De Oliveira LM, Brooker S, Diemert D, Correa-Oliveira R, Bethony JM. Stagespecific immune responses in human Necator americanus infection. Parasite Immunol 2007; 29:347-358. (Pubitemid 46944445)
7. Wilson EH, Deehan MR, Katz E, Brown KS, Houston KM, O Grady J, Harnett MM, Harnett W. Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo. Immunology 2003; 109:238-245. (Pubitemid 36683615)
8. Pritchard DI, Brown A. Is Necator americanus approaching a mutualistic symbiotic relationship with humans? Trends Parasitol 2001; 17:169-172. (Pubitemid 32475817)
9. McSorley HJ, Harcus YM, Murray J, Taylor MD, Maizels RM. Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi. J Immunol 2008; 181: 6456-6466.
10. Pastrana DV, Raghavan N, FitzGerald P, Eisinger SW, Metz C, Bucala R, Schleimer RP, Bickel C, Scott AL. Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor. Infect Immun 1998; 66:5955-5963. (Pubitemid 28531858)
11. Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, Finney CA, Greenwood EJ, Knox DP, Wilson MS, Belkaid Y, Rudensky AY, Maizels RM. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway. J Exp Med 2010; 207:2331-2341.
12. Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS. Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment. J Immunol 2009; 182:6907-6914.
13. Cho MK, Lee CH, Yu HS. Amelioration of intestinal colitis by macrophage migration inhibitory factor isolated from intestinal parasites through toll-like receptor 2. Parasite Immunol 2011; 33: 265-275.
14. van den Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbakhsh M. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin- 10. Lancet 2000; 356:1723-1727.
15. Nagler-Anderson C. Helminth-induced immunoregulation of an allergic response to food. Chem Immunol allergy 2006; 90:1-13. (Pubitemid 43265664)
16. Maloy KJ, Salaun L, Cahill R, Dougan G, Saunders NJ, Powrie F. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003; 197: 111-119. (Pubitemid 36110262)
17. Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170:3939-3943. (Pubitemid 36428153)
18. Netea MG, Sutmuller R, Hermann C, Van der Graaf CA, Van der Meer JW, van Krieken JH, Hartung T, Adema G, Kullberg BJ. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol 2004; 172:3712-3718. (Pubitemid 38337955)
19. Saraiva M, O Garra A. The regulation of IL-10 production by immune cells. Nat Rev 2010; 10:170-181.
20. Tonnel AB, Gosset P, Tillie-Leblond I. Characteristics of the inflammatory response in bronchial lavage fluids from patients with status asthmaticus. Inter Arch Allergy Immunol 2001; 124:267-271. (Pubitemid 32304822)
21. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest 2003; 111:291-297. (Pubitemid 36182201)
22. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002; 295: 336-338. (Pubitemid 34074365)