The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 925-934

  Zhao, Huiwu ^a   Jin, Shenghao ^a   Gewirtz, Alan M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTRANSFERASE DOMAIN; CO-IMMUNOPRECIPITATIONS; HEMATOPOIETIC CELL; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; JURKAT CELL; LEUKEMOGENESIS; ONCOPROTEINS; QUANTITATIVE RT-PCR; REGULATORY RELATIONSHIPS; REPORTER ASSAY; TARGET GENES; TRANSACTIVATION DOMAIN; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL ACTIVITY; TUMORIGENESIS;

ASSAYS; CELLS; GENES; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; PROTEIN C MYB; SMALL INTERFERING RNA; TAT INTERACTIVE PROTEIN 60; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GENE TARGETING; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA; LEUKEMIA CELL; LEUKEMOGENESIS; ONCOGENE; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TIP60 GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HEMATOPOIETIC STEM CELLS; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; MUTATION; PROTO-ONCOGENE PROTEINS C-MYB; TRANSCRIPTION, GENETIC;

EID: 84862915746     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279950     Document Type: Article

References (35)

1. Patel, J. H., Du, Y., Ard, P. G., Phillips, C., Carella, B., Chen, C. J., Rakowski, C., Chatterjee, C., Lieberman, P. M., Lane, W. S., Blobel, G. A., and McMahon, S. B. (2004) The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol. Cell. Biol. 24, 10826-10834 (Pubitemid 39603138)
2. Kamine, J., Elangovan, B., Subramanian, T., Coleman, D., and Chinnadurai, G. (1996) Virology 16, 357-366
3. Murr, R., Loizou, J. I., Yang, Y. G., Cuenin, C., Li, H., Wang, Z. Q., and Herceg, Z., (2006) Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat. Cell Biol. 8, 91-99 (Pubitemid 43064802)
4. Bararia, D., Trivedi, A. K., Zada, A. A., Greif, P. A., Mulaw, M. A., Christopeit, M., Hiddemann, W., Bohlander, S. K., and Behre, G. (2008) Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPα. Leukemia 22, 800-807 (Pubitemid 351552629)
5. Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K., and Rosenfeld, M. G. (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein. Cell 110, 55-67 (Pubitemid 34874606)
6. Gaughan, L., Brady, M. E., Cook, S., Neal, D. E., and Robson, C. N. (2001) Tip60 is a co-activator specific for class I nuclear hormone receptors. J. Biol. Chem. 276, 46841-46848
7. Xiao, H., Chung J., Kao, H. Y., and Yang, Y. C. (2003) Tip60 is a corepressor for STAT3. J. Biol. Chem. 278, 11197-11204
8. Gavaravarapu, S., and Kamine, J. (2000) Tip60 inhibits activation of CREB protein by protein kinase A. Biochem. Biophys. Res. Commun. 269, 758-766 (Pubitemid 30440374)
9. Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., and Nakatani, Y. (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102, 463-473
10. Fazzio, T. G., Huff, J. T., and Panning, B. (2008) An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134, 162-174 (Pubitemid 351905738)
11. Gorrini, C., Squatrito, S., Luise, C., Syed, N., Perna, D., Wark, L., Martinato, F., Sardella, D., Verrecchia, A., Bennett, S., Confalonieri, S., Cesaroni, M., Marchesi, F., Gasco, M., Scanziani, E., Capra, M., Mai, S., Nuciforo, P., Crook, T., Lough, J., and Amati, B. (2007) Tip60 is a haplo-insufficient tumor suppressor required for an oncogene-induced DNA damage response. Nature 448, 1603-1607
12. Klempnauer, K. H., Gonda, T. J., and Bishop, J. M. (1982) Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 31, 453-463 (Pubitemid 13178869)
13. Biedenkapp, H., Borgmeyer, U., Sippel, A. E., and Klempnauer, K. H. (1988) Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature 335, 835-837
14. Gewirtz, A. M., Anfossi, G., Venturelli, D., Valpreda, S., Sims, R., and Calabretta, B. (1989) G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science 245, 180-183 (Pubitemid 19193934)
15. Ramsay, R. G., and Gonda, T. J. (2008) MYB function in normal and cancer cells. Nat. Rev. Cancer 8, 523-534 (Pubitemid 351881853)
16. Nason-Burchenal, K., and Wolff, L. (1993) Activation of c-myb is an early bone-marrow event in a murine model for acute promonocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 90, 1619-1623 (Pubitemid 23058225)
17. Barletta, C., Pelicci, P. G., Kenyon, L. C., Smith, S. D., and Dalla-Favera, R. (1987) Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas. Science 235, 1064-1067
18. Clappier, E., Cuccuini, W., Kalota, A., Crinquette, A., Cayuela, J. M., Dik, W. A., Langerak, A. W., Montpellier, B., Nadel, B., Walrafen, P., Delattre, O., Aurias, A., Leblanc, T., Dombret, H., Gewirtz, A. M., Baruchel, A., Sigaux, F., and Soulier, J. (2007) The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 110, 1251-1261 (Pubitemid 47281423)
19. Hess, J. L., Bittner, C. B., Zeisig, D. T., Bach, C., Fuchs, U., Borkhardt, A., Frampton, J., and Slany, R. K. (2006) c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood 108, 297-304 (Pubitemid 43990642)
20. Lidonnici, M. R., Corradini, F., Waldron, T., Bender, T. P., and Calabretta, B. (2008) Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis. Blood 111, 4771-4779
21. Jin, S., Zhao, H., Yi, Y., Nakata, Y., Kalota, A., and Gewirtz, A. (2010) c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J. Clin. Invest. 120, 593-606
22. Shetzline, S. E., Rallapalli, R., Dowd, K. J., Zou, S., Nakata, Y., Swider, C. R., Kalota, A., Choi, J. K., and Gewirtz, A. M. (2004) Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Blood 104, 1833-1840 (Pubitemid 39202294)
23. Zhao, H., Kalota, A., Jin, S., and Gewirtz, A. (2009) The c-myb protooncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood 113, 505-516
24. Gu, W., Roeder, R. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (Pubitemid 27357952)
25. Senese, S., Zaragoza, K., Minardi, S., Muradore, I., Ronzoni, S., Passafaro, A., Bernard, L., Draetta, G. F., Alcalay, M., Seiser, C., and Chiocca, S. (2007) Role for histone deacetylase 1 in human tumor cell proliferation. Mol. Cell. Biol. 27, 4784-4795 (Pubitemid 47016131)
26. Müller-Tidow, C., Metzelder, S. K., Buerger, H., Packeisen, J., Ganser, A., Heil, G., Kügler, K., Adigüzel, G., Schwäble, J., Steffen, B., Ludwig, W. D., Heinecke, A., Büchner, T., Berdel, W. E., and Serve, H. (2004) Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia. Leukemia 18, 720-726 (Pubitemid 38500189)
27. Tomita, A., Towatari, M., Tsuzuki, S., Hayakawa, F., Kosugi, H., Tamai, K., Miyazaki, T., Kinoshita, T., and Saito H. (2000) c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. Oncogene 19, 444-451 (Pubitemid 30077346)
28. Saether, T., Berge, T., Ledsaak, M., Matre, V., Alm-Kristiansen, A. H., Dahle, O., Aubry, F., and Gabrielsen, O. (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J. Biol. Chem. 282, 13994-14005 (Pubitemid 47100410)
29. Nomura, T., Tanikawa, J., Akimaru, H., Kanei-Ishii, C., Ichikawa-Iwata, E., Khan, M. M., Ito, H., and Ishii, S. (2004) Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. J. Biol. Chem. 279, 16715-16726 (Pubitemid 38509374)
30. Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., and Zhao K. (2009) Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138, 1019-1031
31. Squatrito, M., Gorrini, C., and Amati B. (2006) Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol. 16, 433-442 (Pubitemid 44293403)
32. Shiota, M., Yokomizo, A., Masubuchi, D., Tada, Y., Inokuchi, J., Eto, M., Uchiumi, T., Fujimoto, N., and Naito, S. (2010) Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus. Prostate 70, 540-554
33. Kim, J. H., Kim, B., Cai, L., Choi, H. J., Ohgi, K. A., Tran, C., Chen, C., Chung, C. H., Huber, O., Rose, D. W., Sawyers, C. L., Rosenfeld, M. G., and Baek, S. H. (2005) Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes. Nature 434, 921-926 (Pubitemid 40559007)
34. Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., and Behre, G. (2002) Granulocyte inducer C/EBPβ inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 100, 483-490 (Pubitemid 34761110)
35. Friedman, A. (2002) Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis. J. Cell. Biochem. 86, 624-629