Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

Journal of Cellular Biochemistry

Volumn 86, Issue 4, 2002, Pages 624-629

  Friedman, Alan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

c Myb; C EBP ; Cell cycle; Hematopoiesis; Runx1

Indexed keywords

APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; DIMERIZATION; GENE DELETION; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HEMATOPOIESIS; HUMAN; HUMAN CELL; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; STEM CELL; TRANSACTIVATION; ANIMAL; CELL CULTURE; CELL CYCLE G1 PHASE; CYTOLOGY; HEMATOPOIETIC STEM CELL; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMAL; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; DNA-BINDING PROTEINS; G1 PHASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MICE; PROTO-ONCOGENE PROTEINS C-MYB; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; ANIMALS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; PROTO-ONCOGENE PROTEINS;

CCAAT ENHANCER BINDING PROTEIN ALPHA; DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN C MYB; RUNX1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX1;

EID: 0036022118     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10271     Document Type: Review

References (47)

1. ETO, a target of t (8; 21) in acute leukemia, makes distinct contact with multiple histone deacetylases and binds mS in 3A through its oligomerization domain
2. An oligomer complementary to c-Myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines
3. AML1 stimulates G1 to S progression via its transactivation domain
4. c-Myc overcomes cell cycle inhibition by CBFβSMMHC, a myeloid leukemia oncoprotein
5. TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice
6. Only late, nonmitotic stages of granulocyte differentiation in 32Dcl3 cells are blocked by ectopic expression of murine c-Myb and its truncated forms
7. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb
8. Dichotomy of AML1-ETO functions: Growth arrest versus block of differentiation
9. CBFβ-SMMHC, expressed in M4eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells
10. The Core Binding Factor α interaction domain and the smooth muscle myosin heavy chain segment of CBFβ-SMMHC are both required to slow cell proliferation
11. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
12. Constitutive expression of a c-Myb cDNA blocks Friend murine erythroleukemia cell differentiation
13. MyoD induces growth arrest independent of differentiation in normal or transformed cells
14. Regulation of the myeloperoxidase enhancer binding proteins PU.1, C/EBPα,β and δ during granulocyte-lineage specification
15. Leukemogenesis by CBF oncoproteins
16. Transcriptional regulation of granulocyte and monocyte development
17. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
18. G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-Myb
19. The activation domain of transcription factor PU.1 binds the retinoblastoma protein (RB) and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
20. Regulation of the T-cell receptor δ enhancer by functional cooperation between c-Myb and core binding factors
21. PU.1 (Spi-1) and C/EBPα regulate expression of the granulocyte-macrophage colony-stimulating factor receptor α gene
22. Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in langerhans cell commitment
23. Expression of C/EBPβ from the C/EBPα locus is sufficient for normal hematopoiesis in vivo
24. Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation
25. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - A model for overcoming inhibition of proliferation by CBF oncoproteins
26. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
27. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
28. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
29. Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors
30. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
31. The t(8;21) fusion protein downregulates AML1B-dependent transcription of the Flt3/Flk-2/STK1 gene
32. Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor δ and murine leukemia virus enhancers
33. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model
34. A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells
35. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
36. Expression of the AML-1 oncogene shortens the G1 phase of the cell cycle
37. The murine myeloperoxidase promoter contains several functional elements - One element binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1)
38. CCAAT-enhancer binding protein: A component of a differentiation switch
39. C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor
40. C/EBPα by-passes G-CSF signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
41. C/EBPα arrests cell proliferation through direct inhibition of cdk2 and cdk4
42. Acceleration of G1 cooperates with CBFβ-SMMHC to induce acute leukemia in mice
43. Identification of a region which directs monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
44. CCAAT/enhancer binding protein and AML1 synergistically activate the macrophage-colony stimulating factor receptor promoter
45. Absence of G-CSF signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
46. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein a (C/EBPα) is critical for granulopoiesis