Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation

Oncology Reports

Volumn 27, Issue 2, 2012, Pages 504-510

  Wei, Yanan ^a,c   Zhang, Zhenbo ^a   Liao, Hong ^b   Wu, Ling ^a   Wu, Xiaomei ^a   Zhou, Dongmei ^a   Xi, Xiaowei ^a   Zhu, Yaping ^a   Feng, Youji ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

^c TENGZHOU CENTRAL PEOPLE S HOSPITAL   (China)

Author keywords

Endometrial cancer; Estrogen; GPR30; Notch; Proliferation

Indexed keywords

ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR 30; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; ENDOMETRIUM CANCER; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR GENE; WESTERN BLOTTING;

CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; ENDOMETRIAL NEOPLASMS; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84862912924     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1536     Document Type: Article

References (26)

1. Chaudhry P and Asselin E: Resistance to chemotherapy and hormone therapy in endometrial cancer. Endocr Relat Cancer 16: 363-380, 2009.
2. Banno K, Yanokura M, Kobayashi Y, et al: Endometrial cancer as a familial tumor: pathology and molecular carcinogenesis (review). Curr Genomics 10: 127-132, 2009.
3. Hunn J, Dodson MK, Webb J and Soisson AP: Endometrial cancer-current state of the art therapies and unmet clinical needs: the role of surgery and preoperative radiographic assessment. Adv Drug Deliv Rev 61: 890-895, 2009.
4. Axelson H: Notch signaling and cancer: emerging complexity.Semin Cancer Biol 14: 317-319, 2004.
5. Qiao L and Wong BC: Role of Notch signaling in colorectal cancer. Carcinogenesis 30: 1979-1986, 2009.
6. Rose SL: Notch signaling pathway in ovarian cancer. Int J Gynecol Cancer 19: 564-566, 2009.
7. Mumm JS and Kopan R: Notch signaling: from the outside in. Dev Biol 228: 151-165, 2000. (Pubitemid 32011983)
8. Iso T, Kedes L and Hamamori Y: HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 194: 237-255, 2003. (Pubitemid 36176887)
9. Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 284: 770-776, 1999. (Pubitemid 29291335)
10. Wang Z, Zhang Y, Li Y, Banerjee S, Liao J and Sarkar FH: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 5: 483-493, 2006.
11. Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ and Foreman KE: Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 24: 6333-6344, 2005. (Pubitemid 41486467)
12. Revankar CM, Cimino DF, Sklar LA, Arterburn JB and Prossnitz ER: A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307: 1625-1630, 2005. (Pubitemid 40354745)
13. He YY, Cai B, Yang YX, Liu XL and Wan XP: Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer Sci 100: 1051-1061, 2009.
14. Engelsen IB, Stefansson IM, Akslen LA and Salvesen HB: GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. Am J Obstet Gynecol 199: 543.e1-543.e7, 2008.
15. Sun PM, Gao M, Wei LH, et al: An estrogen receptor alpha-dependent regulation of estrogen receptor-related receptor alpha in the proliferation of endometrial carcinoma cells. Int J Gynecol Cancer 16 (Suppl 2): 564-568, 2006. (Pubitemid 44410970)
16. Zang S, Ji C, Qu X, et al: A study on Notch signaling in human breast cancer. Neoplasma 54: 304-310, 2007.
17. Fox V, Gokhale PJ, Walsh JR, Matin M, Jones M and Andrews PW: Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation. Stem Cells 26: 715-723, 2008.
18. Magri M, Yatim A, Benne C, et al: Notch ligands potentiate IL-7-driven proliferation and survival of human thymocyte precursors. Eur J Immunol 39: 1231-1240, 2009.
19. Taghon T, Van de Walle I, De Smet G, et al: Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development. Blood 113: 3254-3263, 2009.
20. Zhang XP, Zheng G, Zou L, et al: Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol Cell Biochem 307: 101-108, 2008. (Pubitemid 350238652)
21. Albanito L, Madeo A, Lappano R, et al: G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res 67: 1859-1866, 2007. (Pubitemid 46383413)
22. McMillan J, Fatehi-Sedeh S, Sylvia VL, et al: Sex-specific regulation of growth plate chondrocytes by estrogen is via multiple MAP kinase signaling pathways. Biochim Biophys Acta 1763: 381-392, 2006.
23. Mifsud W and Bateman A: Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain.Genome Biol 3: research0068.1-0068.5, 2002.
24. Losel RM, Falkenstein E, Feuring M, et al: Non-genomic steroid action: controversies, questions, and answers. Physiol Rev 83: 965-1016, 2003.
25. Smith HO, Leslie KK, Singh M, et al: GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol 196: 386.e1-386.e11, 2007.
26. Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA and Hathaway HJ: Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 70: 165-190, 2008. (Pubitemid 351738176)