Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics

Micro and Nano Letters

Volumn 6, Issue 6, 2011, Pages 417-421

  Jiang, Chunxiang ^a   Li, Xiang ^a   Yan, Fei ^a   Wang, Zhanhui ^a   Jin, Qiaofeng ^a   Cai, Feiyan ^a   Qian, Ming ^a   Liu, Xin ^a   Zhang, Lijuan ^a   Zheng, Hairong ^a  

^a SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

6-COUMARIN; ACOUSTIC BACKSCATTERING; CDTE; DEGREE OF CONTROL; DIAGNOSTIC ULTRASOUND; DUAL-MODALITY IMAGING; EFFECTIVE CONTRAST AGENTS; FLUORESCENT PROBES; GAS PRESSURES; IN-VIVO; INHERENT LIMITATIONS; INTEGRATED MICROFLUIDIC DEVICES; LIPID SHELL; LIQUID FLOW VELOCITY; MECHANICAL AGITATION; MICROBUBBLES; MOLECULAR IMAGING; MONODISPERSE; PACLITAXEL; POLYDISPERSE SIZE DISTRIBUTIONS; POTENTIAL APPLICATIONS; PREPARATION TECHNOLOGY; SAFETY CONCERNS; SUPERPARAMAGNETIC IRON OXIDES; THERAPEUTIC APPLICATION; ULTRASOUND CONTRAST AGENT; ULTRASOUND MOLECULAR IMAGING;

DRUG DELIVERY; FUNCTIONAL POLYMERS; IRON OXIDES; POLYDISPERSITY; SUPERPARAMAGNETISM; SURFACE ACTIVE AGENTS; ULTRASONICS;

MICROFLUIDICS;

COUMARIN DERIVATIVE; ECHO CONTRAST MEDIUM; FLUORESCENT DYE; IRON OXIDE; PACLITAXEL; QUANTUM DOT;

ARTICLE; BINDING AFFINITY; CELL SURFACE; DRUG DELIVERY SYSTEM; FLOW RATE; FLUORESCENCE; GAS; HUMAN; HUMAN CELL; IN VIVO CULTURE; LIQUID; MAGNET; MICROBUBBLE; MICROENCAPSULATION; MICROFLUIDICS; MOLECULAR IMAGING; NANOFABRICATION; PARTICLE SIZE; PROTEIN EXPRESSION; ULTRASOUND;

EID: 84862909227     PISSN: None     EISSN: 17500443     Source Type: Journal    
DOI: 10.1049/mnl.2011.0141     Document Type: Article

References (22)

1. Klibanov, A.L., Rychak, J.J., and Yang, W.C.: et al. ' Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow ', Contrast Media Mol. Imaging, 2006, 1, p. 259-266 10.1002/cmmi.113
2. Weller, G.E.R., Wong, M.K.K., and Modzelewski, R.A.: et al. ' Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine ', Cancer Res., 2005, 65, p. 533-539
3. Ferrara, K., Pollard, R., and Borden, M.: ' Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery ', Annu. Rev. Biomed. Eng., 2007, 9, p. 415-447 10.1146/annurev.bioeng.8.061505.095852 (Pubitemid 350246663)
4. Unger, E.C., Porter, T., and Culp, W.: et al. ' Therapeutic applications of lipid-coated microbubbles ', Adv. Drug Deliv. Rev., 2004, 56, p. 1291-1314 10.1016/j.addr.2003.12.006 (Pubitemid 38510475)
5. Unger, E., Metzger, P., and Krupinski, E.: et al. ' The use of a thrombus-specific ultrasound contrast agent to detect thrumbus in arteriovenous fistulae ', Invest. Tadiol., 2000, 35, p. 86-89 10.1097/00004424-200001000-00010 (Pubitemid 30033611)
6. Burns, M.A., Johnson, B.N., and Brahmasandra, S.N.: et al. ' An integrater nanoliter DNA analysis device ', Science, 1998, 282, p. 484-487 10.1126/science.282.5388.484 0036-8075 (Pubitemid 28483677)
7. Chou, H.P., Spence, C., and Scherer, A.: et al. ' A microfabricated device for sizing and sorting DNA molecules ', Proc. Natl. Acad. Sci. USA, 1999, 96, p. 11-13 10.1073/pnas.96.1.11 0027-8424 (Pubitemid 29036043)
8. Michael, G.R., Christopher, J.E., and James, P.L.: ' Advances in polymerase chain reaction on microfluidic chips ', Anal. Chem., 2005, 77, p. 3887-3894 10.1021/ac050756m 0003-2700 (Pubitemid 40848055)
9. Kopp, M.U., Mello, A.J., and Manz, A.: ' Chemical amplification: continuous-flow PCR on a chip ', Science, 1998, 280, p. 1046-1048 10.1126/science.280.5366.1046 0036-8075 (Pubitemid 28234939)
10. Carl, L.H., Skordalakes, E., Berger, J.M., and Quake, S.R.: ' A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion ', Proc. Natl. Acad. Sci. USA, 2002, 99, p. 16531-16536 10.1073/pnas.262485199 0027-8424 (Pubitemid 36034007)
11. Zheng, B., Roach, L.S., and Ismagilov, R.F.: ' Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets ', J. Am. Chem. Soc., 2003, 125, p. 11170-11171 10.1021/ja037166v 0002-7863 (Pubitemid 37108033)
12. Wang, Z., Kim, M.C., and Maarguez, M.: et al. ' High-density microfluidic arrays for cell cytotoxicity analysis ', Lab Chip, 2007, 7, p. 740-745 10.1039/b618734j 1473-0197 (Pubitemid 46848696)
13. Chen, X., Wu, H., and Mao, C.: et al. ' A prototype two-dimensional capillary electrophoresis system fabricated in poly(dimethylsiloxane) ', Anal. Chem., 2002, 74, p. 1772-1778 10.1021/ac0109422 0003-2700 (Pubitemid 34303739)
14. Ramsey, J.D., Jacobson, S.C., and Culbertson, C.T.: et al. ' High-efficiency, two-dimensional separations of protein digests on microfluidic devices ', Anal. Chem., 2003, 75, p. 3758-3764 10.1021/ac0264574 0003-2700 (Pubitemid 36962109)
15. Gu, W., Zhu, X., and Futa, N.: et al. ' Computerized microfluidic cell culture using elastomeric channels and Braille displays ', Proc. Natl. Acad. Sci. USA, 2004, 101, p. 15861-15866 10.1073/pnas.0404353101 0027-8424 (Pubitemid 39507892)
16. Tourovskaia, A., Figueroa-Masot, X., and Folch, A.: ' Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies ', Lab Chip, 2005, 5, p. 14-19 10.1039/b405719h 1473-0197 (Pubitemid 40139334)
17. Anna, S., Bontoux, N., and Stone, H.: ' Formation of dispersions using flow focusing in microchannels ', Appl. Phys. Lett., 2003, 82, p. 364-366 10.1063/1.1537519 0003-6951
18. Nisisako, T., Torii, T., and Higuchi, T.: ' Droplet formation in a microchannel network ', Lab Chip, 2002, 2, p. 24-26 10.1039/b108740c 1473-0197 (Pubitemid 37248114)
19. Garstecki, P., Fuerstman, M.J., and Stonec, H.A.: et al. ' Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up ', Lab Chip, 2006, 6, p. 437-446 10.1039/b510841a 1473-0197 (Pubitemid 43327570)
20. Hettiarachchi, K., Talu, E., and Longo, M.L.: et al. ' On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging ', Lab Chip, 2007, 7, p. 463-468 10.1039/b701481n 1473-0197 (Pubitemid 46496557)
21. Garstecki, P., Gitlin, I., and Diluzio, W.: et al. ' Formation of monodisperse bubbles in a microfluidic flow-focusing device ', Appl. Phys. Lett., 2008, 85, p. 2649-2651 10.1063/1.1796526 0003-6951
22. Hashimoto, M., Shevkoplyas, S.S., and Zasonska, B.: et al. ' Formation of bubbles and droplets in parallel, coupled flow-focusing geometries ', Small, 2008, 4, p. 1795-1805 10.1002/smll.200800591