Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation

Experimental Cell Research

Volumn 318, Issue 14, 2012, Pages 1673-1684

  Haidari, Mehran ^a,b   Zhang, Wei ^b   Chen, Zhenping ^b   Ganjehei, Leila ^b   Mortazavi, Ahmadreza ^b   Warier, Navin ^b   Vanderslice, Peter ^b   Dixon, Richard A F ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b ST LUKE S EPISCOPAL HOSPITAL   (United States)

Author keywords

Adherens junction; Atorvastatin; HRas; RhoA; Statins; VE cadherin

Indexed keywords

ATORVASTATIN; BETA CATENIN; FARNESYL TRANS TRANSFERASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYOSIN LIGHT CHAIN PHOSPHATASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TYROSINE; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; ATTENUATION; CELL JUNCTION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; MONOCYTE; ONCOGENE H RAS; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 84862906937     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.05.009     Document Type: Article

References (30)

1. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:68-74.
2. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Gene 1993, 9:317-321.
3. McCrea P.D., Gumbiner B.M. Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure. J. Biol. Chem. 1991, 266:4514-4520.
4. Geiger B., Cadherins Ayalon O. Annu. Rev. Cell Biol. 1992, 8:307-332.
5. Dejana E., Orsenigo F., Lampugnani M.G. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J. Cell Sci. 2008, 121:2115-2122.
6. Sandig M., Negrou E., Rogers K.A. Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture. J. Cell Sci. 1997, 110:2807-2818.
7. Ionescu C.V., Cepinskas G., Savickiene J., Sandig M., Kvietys P.R. Neutrophils induce sequential focal changes in endothelial adherens junction components: role of elastase. Microcirculation 2003, 10:205-220.
8. Shen Q., Rigor R.R., Pivetti C.D., Wu M.H., Yuan S.Y. Myosin light chain kinase in microvascular endothelial barrier function. Cardiovasc. Res. 2010, 87:272-280.
9. Haidari M., Zhang W., Chen Z., Ganjehei L., Warier N., Vanderslice P., Dixon R. Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions. Cardiovasc. Res. 2011, 92:456-465.
10. Bokoch G.M., Der C.J. Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J. 1993, 7:750-759.
11. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2001, 117:3720-3732.
12. Furie M.B., McHugh D.D. Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha. J. Immunol. 1989, 143:3309-3317.
13. Moser R., Schleiffenbaum B., Groscurth P., Fehr J. Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J. Clin Invest. 1989, 83:444-455.
14. Di Ciano-Oliveira C., Lodyga M., Fan L., Szászi K., Hosoya H., Rotstein O.D., Kapus A. Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?. Am. J. Physiol. Cell Physiol. 2005, 289:C68-C81.
15. Potter M.D., Barbero S., Cheresh D.A. Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state. J. Biol. Chem. 2005, 280:31906-31912.
16. Allingham M.J., van Buul J.D., Burridge K. ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J. Immunol. 2007, 179:4053-4064.
17. Mong P.Y., Wang Q. Activation of Rho kinase isoforms in lung endothelial cells during inflammation. J. Immunol. 2009, 182:2385-2394.
18. Amano M., Ito M., Kimura K., Fukata Y., Chihara K., Nakano T., Matsuura Y., Kaibuchi K. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 1996, 271:20246-20249.
19. Goeckeler Z.M., Wysolmerski R.B. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J. Cell Biol. 1995, 130:613-627.
20. Klemke R.L., Cai S., Giannini A.L., Gallagher P.J., de Lanerolle P., Cheresh D.A. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 1997, 137:481-492.
21. Waheed F., Speight P., Kawai G., Dan Q., Kapus A., Szászi K. Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. Am. J. Physiol. Cell Physiol. 2010, 298:C1376-C1387.
22. Lambeng N., Wallez Y., Rampon C., Cand F., Christe G., Gulino-Debrac D., Vilgrain I., Huber P. Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues. Circ. Res. 2005, 96:384-391.
23. Joyce M., Casey R., Gang C., Winter D., Kelly C.J., Bouchier-Hayes D.J. Hydroxymethylglutaryl co-enzyme A reductase inhibition attenuates endotoxin-mediated inflammatory responses. Br. J. Surg. 2005, 92:1034-1040.
24. Greenwood J., Walters C.E., Pryce G., Kanuga N., Beraud E., Baker D., Adamson P. Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB J. 2003, 17:905-907.
25. Kusama T., Mukai M., Tatsuta M., Nakamura H., Inoue M. Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. Int. J. Oncol. 2006, 29:217-223.
26. Frost J.A., Xu S., Hutchison M.R., Marcus S., Cobb M.H. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol. Cell Biol. 1996, 16:3707-3713.
27. Li W., Chong H., Guan K.L. Function of the Rho family GTPases in Ras-stimulated Raf activation. J. Biol. Chem. 2001, 276:34728-34737.
28. Khosravi-Far R., Solski P.A., Clark G.J., Kinch M.S., Der C.J. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell Biol. 1995, 15:6443-6453.
29. Miyake Y., Inoue N., Nishimura K., Kinoshita N., Hosoya H., Yonemura S. Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. Exp. Cell Res. 2006, 312:1637-1650.
30. Bruewer M., Hopkins A.M., Hobert M.E., Nusrat A., Madara J.L. RhoA Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am. J. Physiol. Cell Physiol. 2004, 287:C327-C335.