Hydroxymethylglutaryl co-enzyme A reductase inhibition attenuates endotoxin-mediated inflammatory responses

British Journal of Surgery

Volumn 92, Issue 8, 2005, Pages 1034-1040

  Joyce, M ^a   Casey, R ^a   Gang, C ^a   Winter, D ^a   Kelly, C J ^a   Bouchier Hayes, D J ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ENDOTOXIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; PRAVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; INFLAMMATION; LEUKOCYTE; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VELOCITY;

ANALYSIS OF VARIANCE; ANIMALS; CELL ADHESION; CELL MOVEMENT; CHOLESTEROL; ENDOTHELIAL CELLS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; MESENTERY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PRAVASTATIN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 23844465176     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.4985     Document Type: Article

References (40)

1. Munro JM, Cotran RS. The pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest 1988; 58: 249-261.
2. Harris NR, Russell JM, Granger DN. Mediators of endotoxin-induced leukocyte adhesion in mesenteric postcapillary venules. Circ Shock 1994; 43: 155-160.
3. Shanley TP, Warner RL, Ward PA. The role of cytokines and adhesion molecules in the development of inflammatory injury. Mol Med Today 1995; 1: 40-45.
4. Granger DN, Kubes P. The microcirculation and inflammation: modulation of leucocyte-endothelial cell adhesion. J Leukoc Biol 1994; 55: 662-675.
5. Davenpeck KL, Steeber DA, Tedder TF, Bochner BS. P- and L-selectin mediate distinct but overlapping functions in endotoxin-induced leukocyte-endothelial interactions in the rat mesenteric microcirculation. J Immunol 1997; 159: 1977-1986.
6. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993; 328: 1471-1477.
7. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, Stoclet JC. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990; 259: H1038-H1043.
8. Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991; 338: 1557-1558.
9. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990; 172: 1132-1138.
10. Wiedermann CJ, Kiechl S, Dunzendorfer S, Schratzberger P, Egger G, Oberhollenzer F et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck study. J Am Coll Cardiol 1999; 34: 1975-1981.
11. Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F et al. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation 2001; 103: 1064-1070.
12. Mamode N, Cobbe S, Pollock JG. Infarcts after surgery. BMJ 1995; 310: 1215-1216.
13. Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV, Hoen H et al. Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program. Circulation 1995; 92: 2419-2425.
14. Randomisedtrial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 1994; 344: 1383-1389.
15. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333: 1301-1307.
16. Vaughan CJ, Murphy MB, Buckley BM. Statins do more than just lower cholesterol. Lancet 1996; 348: 1079-1082.
17. Delanty N, Vaughan CJ. Vascular effects of statins in stroke. Stroke 1997; 28: 2315-2320.
18. Palinsk W. New evidence for beneficial effects of statins unrelated to lipid lowering. Arterioscler Throm Vasc Biol 2001; 21: 3-5.
19. Ando H, Takamura T, Ota T, Nagai Y, Kobayashi K. Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. J Pharmacol Exp Ther 2000; 294: 1043-1046.
20. Pahan K, Sheikh FG, Namboodiri AM, Singh I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest 1997; 100: 2671-2679.
21. Kimura M, Kurose I, Russell J, Granger DN. Effects of fluvastatin on leucocyte-endothelial cell adhesion in hypercholesterolemic rats. Arterioscler Throm Vasc Biol 1997; 17: 1521-1526.
22. Laufs U, La Fata V, PlutzkyJ, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998; 97: 1129-1135.
23. Kaesemeyer WH, Caldwell RB, Huang J, Caldwell RW. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions. J Am Coll Cardiol 1999; 33: 234-241.
24. Poldermans D, Bax JJ, Kertai MD, Krenning B, Westerhout CM, Schinkel AF et al. Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery. Circulation 2003; 107: 1848-1851.
25. Chan AW, Bhatt DL, Chew DP, Quinn MJ, Moliterno DJ, Topol EJ et al. Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention. Circulation 2002; 105: 691-696.
26. Schmidt W, Hacker A, Gebhard MM, Martin E, Schmidt H. Dopexamine attenuates endotoxin-induced microcirculatory changes in rat mesentery: role of 2 adrenoceptors. Crit Care Med 1998; 26: 1639-1645.
27. Granger DN, Benoit JN, Suzuki M, Grisham MB. Leucocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol 1989; 257: G683-G688.
28. Perry MA, Granger DN. Role of GD11/CD18 in shear rate-dependent leucocyte-endothelial cell interactions in cat mesenteric venules. J Clin Invest 1991; 87: 1798-1804.
29. Liao JK, Shin WS, Lee WY, Clark SL. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 1995; 270: 319-324.
30. Hesse DG, Tracey KJ, Fong Y, Manogue KR, Palladino MA Jr, Cerami A et al. Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 1988; 166: 147-153.
31. Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, Van der Meer JW et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 1990; 161: 79-84.
32. Thiemermann C, Szabo C, Mitchell JA, Vane JR. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in haemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci USA 1993; 90: 267-271.
33. Ochoa JB, Udekwu AO, Billiar TR, Curran RD, Cerra FB, Simmons RL et al. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991; 214: 621-626.
34. Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 2001; 345: 588-595.
35. Deitch EA. Animal models of sepsis and shock: a review and lessons learned. Shock 1998; 9: 1-11.
36. Pruefer D, Scalia R, Lefer AM. Simvastatin inhibits leucoctye-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. Arterioscler Thromb Vasc Biol 1999; 19: 2894-2900.
37. Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA Jr et al. HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 2001; 21: 1165-1171.
38. Rice JB, Stoll LL, Li WG, Denning GM, Weydert J, Charipar E et al. Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. Arterioscler Thromb Vasc Biol 2003; 23: 1576-1582.
39. Pruefer D, Mokowski J, Schell M et al. Simvastatin inhibits inflammatory properties of staphylococcus aureus α-toxins. Circulation 2002; 106: 2104-2110.
40. Endres M, Laufs U, Huang Z, Nakamura T, Haung P, Moskowitz MA et al. Stroke protection by 3-hydroxyl 3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA 1998; 95: 8880-8885.