Olfactory identification testing as a predictor of the development of Alzheimer's dementia: A systematic review

Laryngoscope

Volumn 122, Issue 7, 2012, Pages 1455-1462

  Sun, Gordon H ^a,b,c   Raji, Cyrus A ^d   MacEachern, Mark P ^a   Burke, James F ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; anosmia; hyposmia; mild cognitive impairment; olfaction; screening; smell test

Indexed keywords

ALZHEIMER DISEASE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FOLLOW UP; FUNCTION TEST; HUMAN; HYPOSMIA; LONGITUDINAL STUDY; MILD COGNITIVE IMPAIRMENT; NEUROLOGIC EXAMINATION; OLFACTORY IDENTIFICATION TEST; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; REVIEW;

ALZHEIMER DISEASE; HUMANS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SMELL;

EID: 84862884850     PISSN: 0023852X     EISSN: 15314995     Source Type: Journal    
DOI: 10.1002/lary.23365     Document Type: Review

References (68)

1. Mayeux R,. Clinical practice. Early Alzheimer's disease. N Engl J Med 2010; 362: 2194-2201.
2. Reitz C, Brayne C, Mayeux R,. Epidemiology of Alzheimer disease. Nat Rev Neurol 2011; 7: 137-152.
3. Aisen PS, Andrieu S, Sampaio C, et al. Report of the task force on designing clinical trials in early (predementia) AD. Neurology 2011; 76: 280-286.
4. Getsios D, Blume S, Ishak KJ, Maclaine G, Hernandez L,. An economic evaluation of early assessment for Alzheimer's disease in the United Kingdom. Alzheimers Dement 2012; 8: 22-30.
5. Doty RL, Reyes PF, Gregor T,. Presence of both odor identification and detection deficits in Alzheimer's disease. Brain Res Bull 1987; 18: 597-600.
6. Murphy C, Gilmore MM, Seery CS, Salmon DP, Lasker BR,. Olfactory thresholds are associated with degree of dementia in Alzheimer's disease. Neurobiol Aging 1990; 11: 465-469.
7. Schiffman SS,. Taste and smell losses in normal aging and disease. JAMA 1997; 278: 1357-1362.
8. Arnold SE, Lee EB, Moberg PJ, et al. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Ann Neurol 2010; 67: 462-469.
9. Attems J, Jellinger KA,. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment. Clin Neuropathol 2006; 25: 265-271.
10. Attems J, Lintner F, Jellinger KA,. Olfactory involvement in aging and Alzheimer's disease: an autopsy study. J Alzheimers Dis 2005; 7: 149-157; discussion 173-180.
11. Wesson DW, Wilson DA, Nixon RA,. Should olfactory dysfunction be used as a biomarker of Alzheimer's disease? Expert Rev Neurother 2010; 10: 633-635.
12. Doty RL,. Office procedures for quantitative assessment of olfactory function. Am J Rhinol 2007; 21: 460-473.
13. Doty RL, Shaman P, Dann M,. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984; 32: 489-502.
14. Doty RL, Shaman P, Kimmelman CP, Dann MS,. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984; 94: 176-178.
15. Jackman AH, Doty RL,. Utility of a three-item smell identification test in detecting olfactory dysfunction. Laryngoscope 2005; 115: 2209-2212.
16. Doty RL,. Olfactory dysfunction and its measurement in the clinic and workplace. Int Arch Occup Environ Health 2006; 79: 268-282.
17. Negoias S, Troeger C, Rombaux P, Halewyck S, Hummel T,. Number of descriptors in cued odor identification tests. Arch Otolaryngol Head Neck Surg 2010; 136: 296-300.
18. Moher D, Liberati A, Tetzlaff J, Altman DG,. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151: 264-269, W264.
19. Johnson SL,. Research and statistics: a question of time: cross-sectional versus longitudinal study designs. Pediatr Rev 2010; 31: 250-251.
20. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J,. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 2003; 3: 25.
21. Bahar-Fuchs A, Chetelat G, Villemagne VL, et al. Olfactory deficits and amyloid-beta burden in Alzheimer's disease, mild cognitive impairment, and healthy aging: a PiB PET study. J Alzheimers Dis 2010; 22: 1081-1087.
22. Bahar-Fuchs A, Moss S, Rowe C, Savage G,. Olfactory performance in AD, aMCI, and healthy ageing: a unirhinal approach. Chem Senses 2010; 35: 855-862.
23. Bahar-Fuchs A, Moss S, Rowe C, Savage G,. Can I smell gas (or is it lilac)? Olfactory semantic deficits in mild cognitive impairment and Alzheimer's disease. Chemosens Percept 2010; 3: 118-128.
24. Devanand DP, Michaels-Marston KS, Liu X, et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry 2000; 157: 1399-1405.
25. Tabert MH, Liu X, Doty RL, et al. A 10-item smell identification scale related to risk for Alzheimer's disease. Ann Neurol 2005; 58: 155-160.
26. Devanand DP, Liu X, Tabert MH, et al. Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease. Biol Psychiatry 2008; 64: 871-879.
27. Bahar-Fuchs A, Moss S, Rowe C, Savage G,. Awareness of olfactory deficits in healthy aging, amnestic mild cognitive impairment and Alzheimer's disease. Int Psychogeriatr 2011; 23: 1097-1106.
28. Rowe CC, Ng S, Ackermann U, et al. Imaging beta-amyloid burden in aging and dementia. Neurology 2007; 68: 1718-1725.
29. Jungwirth S, Zehetmayer S, Bauer P, Weissgram S, Tragl KH, Fischer P,. Screening for Alzheimer's dementia at age 78 with short psychometric instruments. Int Psychogeriatr 2009; 21: 548-559.
30. Lafreniere D, Mann N,. Anosmia: loss of smell in the elderly. Otolaryngol Clin North Am 2009; 42: 123-131, x.
31. Knopman DS, DeKosky ST, Cummings JL, et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001; 56: 1143-1153.
32. Mesholam RI, Moberg PJ, Mahr RN, Doty RL,. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998; 55: 84-90.
33. Corwin J,. Olfactory identification in hemodialysis: acute and chronic effects on discrimination and response bias. Neuropsychologia 1989; 27: 513-522.
34. Lutterotti A, Vedovello M, Reindl M, et al. Olfactory threshold is impaired in early, active multiple sclerosis. Mult Scler 2011; 17: 964-969.
35. Negoias S, Croy I, Gerber J, et al. Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 2010; 169: 415-421.
36. Aisen PS, Petersen RC, Donohue MC, et al. Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement 2010; 6: 239-246.
37. Rubin R,. Scientists sniff at home Alzheimer's test. May 9, 2001. Available at:. Accessed March 22, 2012.
38. The Dr. Oz Show. Alzheimer's Smell Test. May 31, 2011. Available at:. Accessed March 22, 2012.
39. Caroli A, Frisoni GB,. The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort. Neurobiol Aging 2010; 31: 1263-1274.
40. Jack CR Jr, Albert MS, Knopman DS, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 257-262.
41. Chan A, Tam J, Murphy C, Chiu H, Lam L,. Utility of olfactory identification test for diagnosing Chinese patients with Alzheimer's disease. J Clin Exp Neuropsychol 2002; 24: 251-259.
42. Djordjevic J, Jones-Gotman M, De Sousa K, Chertkow H,. Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 2008; 29: 693-706.
43. Forster S, Vaitl A, Teipel SJ, et al. Functional representation of olfactory impairment in early Alzheimer's disease. J Alzheimers Dis 2010; 22: 581-591.
44. Gray AJ, Staples V, Murren K, Dhariwal A, Bentham P,. Olfactory identification is impaired in clinic-based patients with vascular dementia and senile dementia of Alzheimer type. Int J Geriatr Psychiatry 2001; 16: 513-517.
45. Kareken DA, Doty RL, Moberg PJ, et al. Olfactory-evoked regional cerebral blood flow in Alzheimer's disease. Neuropsychology 2001; 15: 18-29.
46. Kesslak JP, Cotman CW, Chui HC, et al. Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease. Neurobiol Aging 1988; 9: 399-403.
47. Kesslak JP, Nalcioglu O, Cotman CW,. Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease. Neurology 1991; 41: 51-54.
48. Kjelvik G, Sando SB, Aasly J, Engedal KA, White LR,. Use of the brief smell identification test for olfactory deficit in a Norwegian population with Alzheimer's disease. Int J Geriatr Psychiatry 2007; 22: 1020-1024.
49. Knupfer L,. Differences in olfactory test performance between normal aged, Alzheimer and vascular type dementia individuals. Int J Geriatr Psychiatry 1986; 1: 3-14.
50. Koss E, Weiffenbach JM, Haxby JV, Friedland RP,. Olfactory detection and identification performance are dissociated in early Alzheimer's disease. Neurology 1988; 38: 1228-1232.
51. Lange R, Donathan CL, Hughes LF,. Assessing olfactory abilities with the University of Pennsylvania smell identification test: a Rasch scaling approach. J Alzheimers Dis 2002; 4: 77-91.
52. Larsson M, Semb H, Winblad B, Amberla K, Wahlund LO, Backman L,. Odor identification in normal aging and early Alzheimer's disease: effects of retrieval support. Neuropsychology 1999; 13: 47-53.
53. Luzzi S, Snowden JS, Neary D, Coccia M, Provinciali L, Lambon Ralph MA,. Distinct patterns of olfactory impairment in Alzheimer's disease, semantic dementia, frontotemporal dementia, and corticobasal degeneration. Neuropsychologia 2007; 45: 1823-1831.
54. Makowska I, Kloszewska I, Grabowska A, Szatkowska I, Rymarczyk K,. Olfactory deficits in normal aging and Alzheimer's disease in the polish elderly population. Arch Clin Neuropsychol 2011; 26: 270-279.
55. McLaughlin NC, Westervelt HJ,. Odor identification deficits in frontotemporal dementia: a preliminary study. Arch Clin Neuropsychol 2008; 23: 119-123.
56. Moberg PJ, Doty RL, Mahr RN, et al. Olfactory identification in elderly schizophrenia and Alzheimer's disease. Neurobiol Aging 1997; 18: 163-167.
57. Morgan CD, Murphy C,. Olfactory event-related potentials in Alzheimer's disease. J Int Neuropsychol Soc 2002; 8: 753-763.
58. Motomura N, Tomota Y,. Olfactory dysfunction in dementia of Alzheimer's type and vascular dementia. Psychogeriatrics 2006; 6: 19-20.
59. Murphy C, Jernigan TL, Fennema-Notestine C,. Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study. J Int Neuropsychol Soc 2003; 9: 459-471.
60. Pentzek M, Grass-Kapanke B, Ihl R,. Odor identification in Alzheimer's disease and depression. Aging Clin Exp Res 2007; 19: 255-258.
61. Peters JM, Hummel T, Kratzsch T, Lotsch J, Skarke C, Frolich L,. Olfactory function in mild cognitive impairment and Alzheimer's disease: An investigation using psychophysical and electrophysiological techniques. Am J Psychiatry 2003; 160: 1995-2002.
62. Rezek DL,. Olfactory deficits as a neurologic sign in dementia of the Alzheimer type. Arch Neurol 1987; 44: 1030-1032.
63. Royet JP, Croisile B, Williamson-Vasta R, Hibert O, Serclerat D, Guerin J,. Rating of different olfactory judgements in Alzheimer's disease. Chem Senses 2001; 26: 409-417.
64. Serby M, Larson P, Kalkstein D,. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry 1991; 148: 357-360.
65. Steinbach S, Hundt W, Vaitl A, et al. Taste in mild cognitive impairment and Alzheimer's disease. J Neurol 2010; 257: 238-246.
66. Suzuki Y, Yamamoto S, Umegaki H, et al. Smell identification test as an indicator for cognitive impairment in Alzheimer's disease. Int J Geriatr Psychiatry 2004; 19: 727-733.
67. Warner MD, Peabody CA, Flattery JJ, Tinklenberg JR,. Olfactory deficits and Alzheimer's disease. Biol Psychiatry 1986; 21: 116-118.
68. Westervelt HJ, Bruce JM, Coon WG, Tremont G,. Odor identification in mild cognitive impairment subtypes. J Clin Exp Neuropsychol 2008; 30: 151-156.