In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 6, 2012, Pages 633-639

  Wustrow, Isabel ^a   Riedel, Klaus Dieter ^a   Mikus, Gerd ^a   Weiss, Johanna ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Bisnortilidine; CYP; Cytochrome P450; Metabolism; Nortilidine; Tilidine

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DINORTILIDINE; DRUG METABOLITE; NORTILIDINE; TILIDINE; UNCLASSIFIED DRUG;

ARTICLE; DEMETHYLATION; DRUG METABOLISM; HUMAN; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MICROSOMES, LIVER; TILIDINE;

EID: 84862871965     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0737-z     Document Type: Article

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