-
1
-
-
70149101223
-
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
-
Wallentin, L. et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1045-1057
-
-
Wallentin, L.1
-
2
-
-
36148983750
-
Prasugrel versus clopidogrel in patients with acute coronary syndromes
-
Wiviott, S. D. et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 2001-2015
-
-
Wiviott, S.D.1
-
3
-
-
0035899289
-
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
-
Yusuf, S. et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N. Engl. J. Med. 345, 494-502 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 494-502
-
-
Yusuf, S.1
-
4
-
-
23644443663
-
Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: Meta-analysis with estimates of risk and benefit
-
Rothberg, M. B., Celestin, C., Fiore, L. D., Lawler, E. & Cook, J. R. Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann. Intern. Med. 143, 241-250 (2005).
-
(2005)
Ann. Intern. Med.
, vol.143
, pp. 241-250
-
-
Rothberg, M.B.1
Celestin, C.2
Fiore, L.D.3
Lawler, E.4
Cook, J.R.5
-
5
-
-
7844220998
-
Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study
-
Bertrand, M. E. et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study. Circulation 98, 1597-1603 (1998).
-
(1998)
Circulation
, vol.98
, pp. 1597-1603
-
-
Bertrand, M.E.1
-
6
-
-
0037179656
-
Warfarin, aspirin, or both after myocardial infarction
-
Hurlen, M., Abdelnoor, M., Smith, P., Erikssen, J. & Arnesen, H. Warfarin, aspirin, or both after myocardial infarction. N. Engl. J. Med. 347, 969-974 (2002).
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 969-974
-
-
Hurlen, M.1
Abdelnoor, M.2
Smith, P.3
Erikssen, J.4
Arnesen, H.5
-
7
-
-
33745058140
-
Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding
-
Khurram, Z. et al. Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding. J. Inv. Cardiol. 18, 162-164 (2006).
-
(2006)
J. Inv. Cardiol.
, vol.18
, pp. 162-164
-
-
Khurram, Z.1
-
8
-
-
57649109102
-
Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment requiring oral anticoagulant therapy
-
Rossini, R. et al. Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment requiring oral anticoagulant therapy. Am. J. Cardiol. 102, 1618-1623 (2008).
-
(2008)
Am. J. Cardiol.
, vol.102
, pp. 1618-1623
-
-
Rossini, R.1
-
9
-
-
0037454050
-
Oral anticoagulants in patients with coronary artery disease
-
Anand, S. S. & Yusuf, S. Oral anticoagulants in patients with coronary artery disease. J. Am. Coll. Cardiol. 41 (Suppl. S), 62S-69S (2003).
-
(2003)
J. Am. Coll. Cardiol.
, vol.41
, Issue.SUPPL. S
-
-
Anand, S.S.1
Yusuf, S.2
-
11
-
-
0032030842
-
Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo
-
Herbert, J. et al. Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo. J. Clin. Invest. 101, 993-1000 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 993-1000
-
-
Herbert, J.1
-
12
-
-
0842308313
-
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis
-
Versteeg, H. H., Spek, C. A., Richel, D. J. & Peppelenbosch, M. P. Coagulation factors VIIa and Xa inhibit apoptosis and anoikis. Oncogene 23, 410-417 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 410-417
-
-
Versteeg, H.H.1
Spek, C.A.2
Richel, D.J.3
Peppelenbosch, M.P.4
-
13
-
-
0037205286
-
Factor Xa releases matrix metalloproteinase-2 (MMP-2) from human vascular smooth muscle cells and stimulates the conversion of pro-MMP-2 to MMP-2: Role of MMP-2 in factor Xa-induced DNA synthesis and matrix invasion
-
Rauch, B. H., Bretschneider, E., Braun, M. & Schror, K. Factor Xa releases matrix metalloproteinase-2 (MMP-2) from human vascular smooth muscle cells and stimulates the conversion of pro-MMP-2 to MMP-2: role of MMP-2 in factor Xa-induced DNA synthesis and matrix invasion. Circ. Res. 90, 1122-1127 (2002).
-
(2002)
Circ. Res.
, vol.90
, pp. 1122-1127
-
-
Rauch, B.H.1
Bretschneider, E.2
Braun, M.3
Schror, K.4
-
14
-
-
0030995868
-
Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo
-
Cirino, G. et al. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest. 99, 2446-2451 (1997).
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 2446-2451
-
-
Cirino, G.1
-
15
-
-
57449094606
-
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
-
Eriksson, B. I., Quinlan, D. J. & Weitz, J. I. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin. Pharmacokinet. 48, 1-22 (2009).
-
(2009)
Clin. Pharmacokinet.
, vol.48
, pp. 1-22
-
-
Eriksson, B.I.1
Quinlan, D.J.2
Weitz, J.I.3
-
16
-
-
45949099359
-
Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
-
Eriksson, B. I. et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N. Engl. J. Med. 358, 2765-2775 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2765-2775
-
-
Eriksson, B.I.1
-
17
-
-
36348978071
-
The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
-
Lassen, M. R. et al. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J. Thromb. Haemost. 5, 2368-2375 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, pp. 2368-2375
-
-
Lassen, M.R.1
-
18
-
-
45949103416
-
Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
-
Lassen, M. R. et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N. Engl. J. Med. 358, 2776-2786 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2776-2786
-
-
Lassen, M.R.1
-
19
-
-
78650587760
-
Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
-
Lassen, M. R. et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N. Engl. J. Med. 363, 2487-2498 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2487-2498
-
-
Lassen, M.R.1
-
20
-
-
79952301326
-
Apixaban in patients with atrial fibrillation
-
Connolly, S. J. et al. Apixaban in patients with atrial fibrillation. N. Engl. J. Med. 364, 806-817 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 806-817
-
-
Connolly, S.J.1
-
21
-
-
80052825103
-
Apixaban versus warfarin in patients with atrial fibrillation
-
Granger, C. B. et al. Apixaban versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 365, 981-992 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 981-992
-
-
Granger, C.B.1
-
22
-
-
80052592404
-
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
-
Patel, M. R. et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N. Engl. J. Med. 365, 883-891 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 883-891
-
-
Patel, M.R.1
-
23
-
-
84862870793
-
Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation
-
Cabral, K. P. & Ansell, J. Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation. Nat. Rev. Cardiol. http://dx.doi.org/10.1038/nrcardio.2012.19
-
Nat. Rev. Cardiol.
-
-
Cabral, K.P.1
Ansell, J.2
-
24
-
-
50449098285
-
Mechanisms of thrombus formation
-
Furie, B. & Furie, B. C. Mechanisms of thrombus formation. N. Engl. J. Med. 359, 938-949 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 938-949
-
-
Furie, B.1
Furie, B.C.2
-
25
-
-
0027402655
-
Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation
-
Morrissey, J. H., Macik, B. G., Neuenschwander, P. F. & Comp, P. C. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 81, 734-744 (1993).
-
(1993)
Blood
, vol.81
, pp. 734-744
-
-
Morrissey, J.H.1
Macik, B.G.2
Neuenschwander, P.F.3
Comp, P.C.4
-
26
-
-
0029744067
-
Transmission of a procoagulant signal from tissue factor-bearing cell to platelets
-
Monroe, D. M., Hoffman, M. & Roberts, H. R. Transmission of a procoagulant signal from tissue factor-bearing cell to platelets. Blood Coagul. Fibrinolysis 7, 459-464 (1996).
-
(1996)
Blood Coagul. Fibrinolysis
, vol.7
, pp. 459-464
-
-
Monroe, D.M.1
Hoffman, M.2
Roberts, H.R.3
-
27
-
-
0034090525
-
Thrombin facilitates primary platelet adhesion onto vascular surfaces in the absence of plasma adhesive proteins: Studies under flow conditions
-
Diaz-Ricart, M. et al. Thrombin facilitates primary platelet adhesion onto vascular surfaces in the absence of plasma adhesive proteins: studies under flow conditions. Haematologica 85, 280-288 (2000).
-
(2000)
Haematologica
, vol.85
, pp. 280-288
-
-
Diaz-Ricart, M.1
-
28
-
-
0025083437
-
Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin
-
Monkovic, D. D. & Tracy, P. B. Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin. J. Biol. Chem. 265, 17132-17140 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17132-17140
-
-
Monkovic, D.D.1
Tracy, P.B.2
-
29
-
-
0025139882
-
Activation of human factor V by factor Xa and thrombin
-
Monkovic, D. D. & Tracy, P. B. Activation of human factor V by factor Xa and thrombin. Biochemistry 29, 1118-1128 (1990).
-
(1990)
Biochemistry
, vol.29
, pp. 1118-1128
-
-
Monkovic, D.D.1
Tracy, P.B.2
-
30
-
-
0021876833
-
Modulation of thrombin-mediated activation of factor VIII:C by calcium ions, phospholipid, and platelets
-
Hultin, M. B. Modulation of thrombin-mediated activation of factor VIII:C by calcium ions, phospholipid, and platelets. Blood 66, 53-58 (1985).
-
(1985)
Blood
, vol.66
, pp. 53-58
-
-
Hultin, M.B.1
-
31
-
-
0030738312
-
Human umbilical vein endothelial cells express high affinity receptors for factor Xa
-
Bono, F. et al. Human umbilical vein endothelial cells express high affinity receptors for factor Xa. J. Cell. Physiol. 172, 36-43 (1997).
-
(1997)
J. Cell. Physiol.
, vol.172
, pp. 36-43
-
-
Bono, F.1
-
32
-
-
0033835351
-
Macrophages synthesize factor X and secrete factor X/Xa-containing prothrombinase activity into the surrounding medium
-
Pejler, G., Lunderius, C. & Tomasini-Johansson, B. Macrophages synthesize factor X and secrete factor X/Xa-containing prothrombinase activity into the surrounding medium. Thromb. Haemost. 84, 429-435 (2000).
-
(2000)
Thromb. Haemost.
, vol.84
, pp. 429-435
-
-
Pejler, G.1
Lunderius, C.2
Tomasini-Johansson, B.3
-
33
-
-
0025310394
-
Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa
-
Altieri, D. C. & Edgington, T. S. Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa. J. Immunol. 145, 246-253 (1990).
-
(1990)
J. Immunol.
, vol.145
, pp. 246-253
-
-
Altieri, D.C.1
Edgington, T.S.2
-
34
-
-
37049044629
-
An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
-
Macfarlane, R. G. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 202, 498-499 (1964).
-
(1964)
Nature
, vol.202
, pp. 498-499
-
-
Macfarlane, R.G.1
-
35
-
-
0014437059
-
Investigation of the apparent thrombogenicity of thrombin
-
Yin, E. T. & Wessler, S. Investigation of the apparent thrombogenicity of thrombin. Thromb. Diath. Haemorrh. 20, 465-468 (1968).
-
(1968)
Thromb. Diath. Haemorrh.
, vol.20
, pp. 465-468
-
-
Yin, E.T.1
Wessler, S.2
-
36
-
-
5144229318
-
Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis
-
Ieko, M. et al. Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis. J. Thromb. Haemost. 2, 612-618 (2004).
-
(2004)
J. Thromb. Haemost.
, vol.2
, pp. 612-618
-
-
Ieko, M.1
-
37
-
-
33646089867
-
The effect of different anticoagulants on thrombin generation
-
Petros, S., Siegemund, T., Siegemund, A. & Engelmann, L. The effect of different anticoagulants on thrombin generation. Blood Coagul. Fibrinolysis 17, 131-137 (2006).
-
(2006)
Blood Coagul. Fibrinolysis
, vol.17
, pp. 131-137
-
-
Petros, S.1
Siegemund, T.2
Siegemund, A.3
Engelmann, L.4
-
38
-
-
82555175367
-
Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system
-
Furugohri, T., Sugiyama, N., Morishima, Y. & Shibano, T. Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system. Thromb. Haemost. 106, 1076-1083 (2011).
-
(2011)
Thromb. Haemost.
, vol.106
, pp. 1076-1083
-
-
Furugohri, T.1
Sugiyama, N.2
Morishima, Y.3
Shibano, T.4
-
39
-
-
84861595221
-
Antithrombin-independent thrombin inhibitors, but not factor Xa inhibitors, enhance thrombin generation in human plasma via inhibition of thrombin-thrombomodulin-protein C system
-
abstract
-
Morishima, Y., Furugohri, T., Shiozaki, Y., Sugiyama, N. & Shibano, T. Antithrombin-independent thrombin inhibitors, but not factor Xa inhibitors, enhance thrombin generation in human plasma via inhibition of thrombin-thrombomodulin-protein C system [abstract]. Blood 108, a914 (2006).
-
(2006)
Blood
, vol.108
-
-
Morishima, Y.1
Furugohri, T.2
Shiozaki, Y.3
Sugiyama, N.4
Shibano, T.5
-
40
-
-
31544452392
-
-
Cardiovascular and Renal Drugs Advisory Committee.
-
Food and Drug Administration, Cardiovascular and Renal Drugs Advisory Committee. Briefing information [online], http://www.fda.gov/ohrms/dockets/ac/ 04/briefing/2004-4069b1.htm (2004).
-
(2004)
Briefing Information [Online]
-
-
-
41
-
-
34250700118
-
Factor Xa or thrombin: Is factor Xa a better target?
-
Ansell, J. Factor Xa or thrombin: is factor Xa a better target? J. Thromb. Haemost. 5 (Suppl. 1), 60-64 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, Issue.SUPPL. 1
, pp. 60-64
-
-
Ansell, J.1
-
42
-
-
33645498094
-
Comparison of fondaparinux and enoxaparin in acute coronary syndromes
-
Yusuf, S. et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N. Engl. J. Med. 354, 1464-1476 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1464-1476
-
-
Yusuf, S.1
-
43
-
-
33645497961
-
Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: The OASIS-6 randomized trial
-
Yusuf, S. et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA 295, 1519-1530 (2006).
-
(2006)
JAMA
, vol.295
, pp. 1519-1530
-
-
Yusuf, S.1
-
44
-
-
67649563209
-
Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
-
Alexander, J. H. et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation 119, 2877-2885 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2877-2885
-
-
Alexander, J.H.1
-
45
-
-
60849097858
-
A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)
-
Turpie, A. G. et al. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thromb. Haemost. 101, 68-76 (2009).
-
(2009)
Thromb. Haemost.
, vol.101
, pp. 68-76
-
-
Turpie, A.G.1
-
46
-
-
80054733922
-
RUBY-1: A randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome
-
Steg, P. G. et al. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Eur. Heart J. 32, 2541-2554 (2011).
-
(2011)
Eur. Heart J.
, vol.32
, pp. 2541-2554
-
-
Steg, P.G.1
-
47
-
-
77953787643
-
Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
-
Ogata, K. et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J. Clin. Pharmacol. 50, 743-753 (2010).
-
(2010)
J. Clin. Pharmacol.
, vol.50
, pp. 743-753
-
-
Ogata, K.1
-
48
-
-
34547810878
-
The discovery of (2R,4R)-N-(4-chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin- 1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor
-
Kohrt, J. T. et al. The discovery of (2R,4R)-N-(4-chlorophenyl)-N-(2- fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem. Biol. Drug Des. 70, 100-112 (2007).
-
(2007)
Chem. Biol. Drug Des.
, vol.70
, pp. 100-112
-
-
Kohrt, J.T.1
-
49
-
-
84862893520
-
Safety evaluation of the factor Xa inhibitor TAK-442 in subjects with acute coronary syndromes: Phase 2 AXIOM-ACS trial results
-
abstract
-
Goldstein, S. et al. Safety evaluation of the factor Xa inhibitor TAK-442 in subjects with acute coronary syndromes: phase 2 AXIOM-ACS trial results [abstract]. Eur. Heart J. 32 (Abstract Suppl.), 414 (2011).
-
(2011)
Eur. Heart J.
, vol.32
, Issue.ABSTRACT SUPPL.
, pp. 414
-
-
Goldstein, S.1
-
50
-
-
34147141000
-
A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
-
Agnelli, G. et al. A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J. Thromb. Haemost. 5, 746-753 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, pp. 746-753
-
-
Agnelli, G.1
-
51
-
-
67649562905
-
Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): A randomised, double-blind, phase II trial
-
Mega, J. L. et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet 374, 29-38 (2009).
-
(2009)
Lancet
, vol.374
, pp. 29-38
-
-
Mega, J.L.1
-
52
-
-
35848929515
-
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)- 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
-
Pinto, D. J. et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2- oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J. Med. Chem. 50, 5339-5356 (2007).
-
(2007)
J. Med. Chem.
, vol.50
, pp. 5339-5356
-
-
Pinto, D.J.1
-
53
-
-
58149458160
-
Apixaban metabolism and pharmacokinetics after oral administration to humans
-
Raghavan, N. et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab. Dispos. 37, 74-81 (2009).
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 74-81
-
-
Raghavan, N.1
-
55
-
-
76749166335
-
In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
-
Wang, L. et al. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab. Dispos. 38, 448-458 (2010).
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 448-458
-
-
Wang, L.1
-
56
-
-
23044505564
-
Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
-
Schulman, S. & Kearon, C. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J. Thromb. Haemost. 3, 692-694 (2005).
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 692-694
-
-
Schulman, S.1
Kearon, C.2
-
57
-
-
80052162121
-
Apixaban with antiplatelet therapy after acute coronary syndrome
-
Alexander, J. H. et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N. Engl. J. Med. 365, 699-708 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 699-708
-
-
Alexander, J.H.1
-
58
-
-
0023258694
-
Thrombolysis in Myocardial Infarction (TIMI) Trial, phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge
-
Chesebro, J. H. et al. Thrombolysis in Myocardial Infarction (TIMI) Trial, phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation 76, 142-154 (1987).
-
(1987)
Circulation
, vol.76
, pp. 142-154
-
-
Chesebro, J.H.1
-
59
-
-
80053336306
-
New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome
-
Davis, E. M., Packard, K. A., Knezevich, J. T. & Campbell, J. A. New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome. Pharmacotherapy 31, 975-1016 (2011).
-
(2011)
Pharmacotherapy
, vol.31
, pp. 975-1016
-
-
Davis, E.M.1
Packard, K.A.2
Knezevich, J.T.3
Campbell, J.A.4
-
60
-
-
28744434950
-
In vitro metabolism of BAY 59-7939-an oral, direct factor Xa inhibitor
-
Weinz, C., Radtke, M., Schmeer, K., Kern, A. & Pleiss, U. In vitro metabolism of BAY 59-7939-an oral, direct factor Xa inhibitor. Drug Metab. Rev. 36, 98-98 (2004).
-
(2004)
Drug Metab. Rev.
, vol.36
, pp. 98-98
-
-
Weinz, C.1
Radtke, M.2
Schmeer, K.3
Kern, A.4
Pleiss, U.5
-
61
-
-
28744434950
-
Metabolism and distribution of [C14]BAY 59-7939-an oral, direct factor Xa inhibitor-in rat, dog and human
-
Weinz, C. et al. Metabolism and distribution of [C14]BAY 59-7939-an oral, direct factor Xa inhibitor-in rat, dog and human. Drug Metab. Rev. 36, 98-98 (2004).
-
(2004)
Drug Metab. Rev.
, vol.36
, pp. 98-98
-
-
Weinz, C.1
-
62
-
-
84862907587
-
Rivaroxaban in patients with a recent acute coronary syndrome
-
Mega, J. L. et al. Rivaroxaban in patients with a recent acute coronary syndrome. N. Engl. J. Med. 366, 9-19 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 9-19
-
-
Mega, J.L.1
-
63
-
-
77953380083
-
Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: Part I (factor Xa inhibitors)
-
Mehta, R. S. Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (factor Xa inhibitors). Expert Rev. Hematol. 3, 227-241 (2010).
-
(2010)
Expert Rev. Hematol.
, vol.3
, pp. 227-241
-
-
Mehta, R.S.1
-
65
-
-
77952039362
-
Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor
-
Fujimoto, T. et al. Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor. J. Med. Chem. 53, 3517-3531 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, pp. 3517-3531
-
-
Fujimoto, T.1
-
66
-
-
74249100188
-
New oral anticoagulants in development
-
Weitz, J. I. New oral anticoagulants in development. Thromb. Haemost. 103, 62-70 (2010).
-
(2010)
Thromb. Haemost.
, vol.103
, pp. 62-70
-
-
Weitz, J.I.1
-
67
-
-
78649720309
-
A dose-finding study with TAK-442, an oral factor Xa inhibitor, in patients undergoing elective total knee replacement surgery
-
Weitz, J. I. et al. A dose-finding study with TAK-442, an oral factor Xa inhibitor, in patients undergoing elective total knee replacement surgery. Thromb. Haemost. 104, 1150-1157 (2010).
-
(2010)
Thromb. Haemost.
, vol.104
, pp. 1150-1157
-
-
Weitz, J.I.1
-
68
-
-
85027942525
-
Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation
-
Lee, C. W. et al. Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. J. Thromb. Thrombolysis 32, 150-157 (2011).
-
(2011)
J. Thromb. Thrombolysis
, vol.32
, pp. 150-157
-
-
Lee, C.W.1
-
69
-
-
0035889148
-
Blood coagulation at the site of microvascular injury: Effects of low-dose aspirin
-
Undas, A., Brummel, K., Musial, J., Mann, K. G. & Szczeklik, A. Blood coagulation at the site of microvascular injury: effects of low-dose aspirin. Blood 98, 2423-2431 (2001).
-
(2001)
Blood
, vol.98
, pp. 2423-2431
-
-
Undas, A.1
Brummel, K.2
Musial, J.3
Mann, K.G.4
Szczeklik, A.5
-
70
-
-
0036660207
-
Thrombin functions during tissue factor-induced blood coagulation
-
Brummel, K. E., Paradis, S. G., Butenas, S. & Mann, K. G. Thrombin functions during tissue factor-induced blood coagulation. Blood 100, 148-152 (2002).
-
(2002)
Blood
, vol.100
, pp. 148-152
-
-
Brummel, K.E.1
Paradis, S.G.2
Butenas, S.3
Mann, K.G.4
-
71
-
-
79960395599
-
Thrombin generation in hemorrhage control and vascular occlusion
-
Mann, K. G. Thrombin generation in hemorrhage control and vascular occlusion. Circulation 124, 225-235 (2011).
-
(2011)
Circulation
, vol.124
, pp. 225-235
-
-
Mann, K.G.1
-
72
-
-
79551659654
-
Dilutional control of prothrombin activation at physiologically relevant shear rates
-
Haynes, L. M., Dubief, Y. C., Orfeo, T. & Mann, K. G. Dilutional control of prothrombin activation at physiologically relevant shear rates. Biophys. J. 100, 765-773 (2011).
-
(2011)
Biophys. J.
, vol.100
, pp. 765-773
-
-
Haynes, L.M.1
Dubief, Y.C.2
Orfeo, T.3
Mann, K.G.4
-
73
-
-
3242770664
-
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomised, double-blind, placebo-controlled trial
-
Diener, H. C. et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364, 331-337 (2004).
-
(2004)
Lancet
, vol.364
, pp. 331-337
-
-
Diener, H.C.1
-
74
-
-
78650619315
-
Oral rivaroxaban for symptomatic venous thromboembolism
-
Bauersachs, R. et al. Oral rivaroxaban for symptomatic venous thromboembolism. N. Engl. J. Med. 363, 2499-2510 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2499-2510
-
-
Bauersachs, R.1
-
75
-
-
25844525489
-
Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
-
Kubitza, D., Becka, M., Voith, B., Zuehlsdorf, M. & Wensing, G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin. Pharmacol. Ther. 78, 412-421 (2005).
-
(2005)
Clin. Pharmacol. Ther.
, vol.78
, pp. 412-421
-
-
Kubitza, D.1
Becka, M.2
Voith, B.3
Zuehlsdorf, M.4
Wensing, G.5
-
76
-
-
84855723464
-
A new era in secondary prevention after acute coronary syndrome
-
Roe, M. T. & Ohman, E. M. A new era in secondary prevention after acute coronary syndrome. N. Engl. J. Med. 366, 85-87(2011).
-
(2011)
N. Engl. J. Med.
, vol.366
, pp. 85-87
-
-
Roe, M.T.1
Ohman, E.M.2
-
77
-
-
83655177669
-
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
-
Tricoci, P. et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N. Engl. J. Med. 366, 20-33 (2011).
-
(2011)
N. Engl. J. Med.
, vol.366
, pp. 20-33
-
-
Tricoci, P.1
-
78
-
-
77953394559
-
Recombinant antidote for reversal of anticoagulation by factor Xa inhibitors
-
abstract
-
Lu, G. et al. Recombinant antidote for reversal of anticoagulation by factor Xa inhibitors [abstract]. Blood 112, a983 (2008).
-
(2008)
Blood
, vol.112
-
-
Lu, G.1
-
79
-
-
34249310268
-
Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases
-
Turpie, A. G. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Arterioscler. Thromb. Vasc. Biol. 27, 1238-1247 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 1238-1247
-
-
Turpie, A.G.1
-
80
-
-
34249337290
-
Biochemical and pharmacological profiles of YM150, an oral direct factor Xa inhibitor
-
abstract
-
Iwatsuki, Y. et al. Biochemical and pharmacological profiles of YM150, an oral direct factor Xa inhibitor [abstract]. Blood 108, a273 (2006).
-
(2006)
Blood
, vol.108
-
-
Iwatsuki, Y.1
-
81
-
-
80054728405
-
YM150, an oral direct inhibitor of factor Xa, demonstrated a predictable and dose-proportional pharmacokinetic/pharmacodynamic profile after single and multiple dosing: Results from three studies
-
abstract
-
Groenendaal-van de Meent, D. et al. YM150, an oral direct inhibitor of factor Xa, demonstrated a predictable and dose-proportional pharmacokinetic/ pharmacodynamic profile after single and multiple dosing: results from three studies [abstract]. Blood 116, a3323 (2010).
-
(2010)
Blood
, vol.116
-
-
Groenendaal-Van De Meent, D.1
-
82
-
-
33645053521
-
Small molecule coagulation cascade inhibitors in the clinic
-
Saiah, E. & Soares, C. Small molecule coagulation cascade inhibitors in the clinic. Curr. Top. Med. Chem. 5, 1677-1695 (2005).
-
(2005)
Curr. Top. Med. Chem.
, vol.5
, pp. 1677-1695
-
-
Saiah, E.1
Soares, C.2
-
83
-
-
22844442726
-
In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct factor Xa inhibitor
-
Perzborn, E. et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct factor Xa inhibitor. J. Thromb. Haemost. 3, 514-521 (2005).
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 514-521
-
-
Perzborn, E.1
-
84
-
-
84856133126
-
Reversal of rivaroxaban mediated anticoagulation in animal models by a recombinant antidote protein (r-Antidote, PRT064445)
-
abstract
-
Lu, G. et al. Reversal of rivaroxaban mediated anticoagulation in animal models by a recombinant antidote protein (r-Antidote, PRT064445) [abstract]. Eur. Heart J. 32 (Abstract Suppl.), 640-641 (2011).
-
(2011)
Eur. Heart J.
, vol.32
, Issue.ABSTRACT SUPPL.
, pp. 640-641
-
-
Lu, G.1
-
85
-
-
77955984416
-
Antithrombotic and anticoagulant profiles of TAK-442, a novel factor Xa inhibitor, in a rabbit model of venous thrombosis
-
Kawamura, M. et al. Antithrombotic and anticoagulant profiles of TAK-442, a novel factor Xa inhibitor, in a rabbit model of venous thrombosis. J. Cardiovasc. Pharmacol. 56, 156-161 (2010).
-
(2010)
J. Cardiovasc. Pharmacol.
, vol.56
, pp. 156-161
-
-
Kawamura, M.1
-
86
-
-
84862848942
-
Comparison of the pharmacokinetics and pharmacodynamics of TAK-442, a novel factor Xa inhibitor, between Japanese acute coronary syndrome patients and healthy Japanese males
-
Nakamura, K. et al. Comparison of the pharmacokinetics and pharmacodynamics of TAK-442, a novel factor Xa inhibitor, between Japanese acute coronary syndrome patients and healthy Japanese males. J. Thromb. Haemost. 9, 107-107 (2011).
-
(2011)
J. Thromb. Haemost.
, vol.9
, pp. 107-107
-
-
Nakamura, K.1
-
87
-
-
79955887785
-
Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS ACS 2-TIMI 51) trial: A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome
-
Gibson, C. M. et al. Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS ACS 2-TIMI 51) trial: a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome. Am. Heart J. 161, 815-821e6 (2011).
-
(2011)
Am. Heart J.
, vol.161
-
-
Gibson, C.M.1
|