Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet in hemostasis

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 4, 2004, Pages 612-618

  Ieko, M ^a   Tarumi, T ^a   Takeda, M ^a   Naito, S ^a   Nakabayashi, T ^a   Koike, T ^b  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Factor Xa inhibitor; Platelet aggregation; Thrombin inhibitor

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; 4 [(2 AMIDINO 1,2,3,4 TETRAHYDRO 7 ISOQUINOLINYLOXY)METHYL] 1 (4 PYRIDINYL) 4 PIPERIDINECARBOXYLIC ACID; ARGATROBAN; BLOOD CLOTTING FACTOR 10A; DALTEPARIN; LOW MOLECULAR WEIGHT HEPARIN; THROMBIN; THROMBOPLASTIN; 4 ((2 AMIDINO 1,2,3,4 TETRAHYDROISOQUINOLIN 7 YLOXY)METHYL) 1 (4 PYRIDINYL)PIPERIDINE 4 CARBOXYLIC ACID MONOMETHANESULFONATE TRIHYDRATE; 4-((2-AMIDINO-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YLOXY)METHYL)-1-(4-PYRIDINYL)PIPERIDINE-4-CARBOXYLIC ACID MONOMETHANESULFONATE TRIHYDRATE; ANTICOAGULANT AGENT; ENZYME INHIBITOR; NAPHTHALENE DERIVATIVE; PIPECOLIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE; PROPIONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; PLASMA; PRIORITY JOURNAL; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; THROMBOCYTE;

ANTICOAGULANTS; BLOOD PLATELETS; CELLS, CULTURED; ENZYME INHIBITORS; FACTOR XA; HEMOSTASIS; HUMANS; NAPHTHALENES; PARTIAL THROMBOPLASTIN TIME; PIPECOLIC ACIDS; PIPERIDINES; PLATELET ACTIVATION; PROPIONIC ACIDS; PROTHROMBIN TIME; PYRIDINES; TETRAHYDROISOQUINOLINES; THROMBIN;

EID: 5144229318     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7933.2004.00649.x     Document Type: Article

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