O-Linked Triazolotriazines: Potent and Selective c-Met Inhibitors

ChemMedChem

Volumn 7, Issue 7, 2012, Pages 1276-1285

  Chen, Fang ^a   Wang, Ying ^a   Ai, Jing ^a,b   Zhan, Zhengsheng ^a   Lv, Yongcong ^a   Liang, Zhongjie ^a   Luo, Cheng ^a   Mei, Desheng ^a   Geng, Meiyu ^a   Duan, Wenhu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

C Met; Selectivity; Triazolotriazines; Tyrosine kinase

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 2,2 DIETHOXY 1 (3 NITROPHENYL)ETHANONE; 2,2 DIETHOXY 1 (4 FLUOROPHENYL)ETHANONE; 2,2 DIETHOXY 1 (4 NITROPHENYL)ETHANONE; 2,2 DIETHOXY 1 PHENYLETHANONE; 3 (2,2 DIETHOXYACETYL)PHENYLBENZOATE; 3 (METHYLTHIO) 6 (3 NITROPHENYL) 1,2,4 TRIAZINE; 3 (METHYLTHIO) 6 (4 NITROPHENYL) 1,2,4 TRIAZINE; 3 (METHYLTHIO) 6 PHENYL 1,2,4 TRIAZINE; 3 [3 (METHYLTHIO) 1,2,4 TRIAZINE 6 YL]PHENYLBENZOATE; 4 (2,2 DIETHOXYACETYL)PHENYLBENZOATE; 4 [3 (METHYLTHIO) 1,2,4 TRIAZINE 6 YL]PHENYLBENZOATE; 6 (3 METHOXYPHENYL) 3 (METHYLTHIO) 1,2,4 TRIAZINE; 6 (4 FLUOROPHENYL) 3 (METHYLTHIO) 1,2,4 TRIAZINE; 6 (4 METHOXYPHENYL) 3 (METHYLTHIO) 1,2,4 TRIAZINE; ANTINEOPLASTIC AGENT; METHYL 4 (2,2 DIETHOXYACETYL)BENZOATE; METHYL 4 [3 (METHYLTHIO) 1,2,4 TRIAZINE 6 YL]PHENYLBENZOATE; PROTEIN KINASE INHIBITOR; RECEPTOR BLOCKING AGENT; SCATTER FACTOR RECEPTOR; SCATTER FACTOR RECEPTOR INHIBITOR; TRIAZOLE DERIVATIVE; TRIAZOLOTRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRIAZINES; TRIAZOLES;

EID: 84862867733     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200145     Document Type: Article

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