In situ monitoring, control and optimization of a liquid-liquid phase separation crystallization

Chemical Engineering Science

Volumn 77, Issue , 2012, Pages 112-121

  Duffy, D ^a,c   Cremin, N ^b   Napier, M ^b   Robinson, S ^b   Barrett, M ^a,c   Hao, Hongxun ^a,c   Glennon, Brian ^a,c  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b Janssen Pharmaceutical   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Crystallization; Oiling out; Particulate processes; Phase change; Process control; Supersaturation

Indexed keywords

CONSTANT LEVEL; CONTROL AND OPTIMIZATION; CONTROL TECHNIQUES; CRYSTALLIZATION BEHAVIOR; IN-SITU; IN-SITU MONITORING; IR SPECTRAL REGIONS; LIQUID PHASE; LIQUID-LIQUID PHASE SEPARATION; OILING OUT; PARTICULATE PROCESS; PHARMACEUTICAL COMPOUNDS; PHASE CHANGE; SINGLE PEAK;

ACETONE; CRYSTALLIZATION; PHASE SEPARATION; PROCESS CONTROL; SUPERSATURATION;

PIPE FLOW;

EID: 84862862093     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.01.047     Document Type: Article

References (26)

1. Abu Bakar M.R., Nagy Z.K., Saleemi A.N., Rielly C.D. The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes. Cryst. Growth Des. 2009, 9:1378-1384.
2. Barrett M., McNamara M., Hao H.X., Barrett P., Glennon B. Supersaturation tracking for the development, optimization and control of crystallization processes. Chem. Eng. Res. Des. 2010, 88:1108-1119.
3. Barrett P., Glennon B. Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM. Chem. Eng. Res. Des. 2002, 80:799-805.
4. Bonnett P.E., Carpenter K.J., Dawson S., Davey R.J. Solution crystallisation via a submerged liquid-liquid phase boundary: oiling out. Chem. Commun. 2003, 698-699.
5. Chew J.W., Black S.N., Chow P.S., Tan R.B.H. Comparison between open-loop temperature control and closed-loop supersaturation control for cooling crystallization of glycine. Ind. Eng. Chem. Res. 2007, 46:830-838.
6. Chow K., Tong H.H.Y., Lum S., Chow A.H.L. Engineering of pharmaceutical materials: an industrial perspective. J. Pharm. Sci. 2008, 97:2855-2877.
7. Deneau E., Steele G. An in-line study of oiling out and crystallization. Org. Process Res. Dev. 2005, 9:943-950.
8. Dunuwila D.D., Carroll L.B., Berglund K.A. An investigation of the applicability of attenuated total-reflection infrared-spectroscopy for measurement of solubility and supersaturation of aqueous citric-acid solutions. J. Cryst. Growth 1994, 137:561-568.
9. Feng L.L., Berglund K.A. ATR-FTIR for determining optimal cooling curves for batch crystallization of succinic acid. Cryst. Growth Des. 2002, 2:449-452.
10. Fevotte G., Klein J.P. Calorimetric methods for the study of batch crystallization processes: some key results. Chem. Eng. Res. Des. 1996, 74:791-796.
11. Fujiwara M., Nagy Z.K., Chew J.W., Braatz R.D. First-principles and direct design approaches for the control of pharmaceutical crystallization. J. Process Control 2005, 15:493-504.
12. Jones A.G. Optimal operation of a batch cooling crystallizer. Chem. Eng. Sci. 1974, 29:1075-1087.
13. Kiesow K., Tumakaka F., Sadowski G. Experimental investigation and prediction of oiling out during crystallization process. J. Cryst. Growth 2008, 310:4163-4168.
14. Lafferrere L., Hoff C., Veesler S. In situ monitoring of the impact of liquid-liquid phase separation on drug crystallization by seeding. Cryst. Growth Des. 2004, 4:1175-1180.
15. Lewiner F., Fevotte G., Klein J.P., Puel F. An online strategy to increase the average crystal size during organic batch cooling crystallization. Ind. Eng. Chem. Res. 2002, 41:1321-1328.
16. Liotta V., Sabesan V. Monitoring and feedback control of supersaturation using ATR-FTIR to produce an active pharmaceutical ingredient of a desired crystal size. Org. Process Res. Dev. 2004, 8:488-494.
17. Mersmann A., Loffelmann M. Crystallization and precipitation: the optimal supersaturation. Chem. Ing. Tech. 1999, 71:1240-1244.
18. Nagy Z.K., Chew J.W., Fujiwara M., Braatz R.D. Comparative performance of concentration and temperature controlled batch crystallizations. J. Process Control 2008, 18:399-407.
19. Nonoyama N., Hanaki K., Yabuki Y. Constant supersaturation control of antisolvent-addition batch crystallization. Org. Process Res. Dev. 2006, 10:727-732.
20. Rohani, S., 2009. Control of Crystallization processes in the pharmaceutical industry. In: Pierucci, S. (Ed.), Proceedings of the 9th International Conference on Chemical and Process Engineering, Aidic Servizi Srl, Rome, Italy, pp. 633-638.
21. Svard M., Gracin S., Rasmuson A.C. Oiling out or molten hydrate-liquid-liquid phase separation in the system vanillin-water. J. Pharm. Sci. 2007, 96:2390-2398.
22. Veesler S., Revalor E., Bottini O., Hoff C. Crystallization in the presence of a liquid-liquid phase separation. Org. Process Res. Dev. 2006, 10:841-845.
23. Woo X.Y., Nagy Z.K., Tan R.B.H., Braatz R.D. Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement. Cryst. Growth Des. 2009, 9:182-191.
24. Yu Z.Q., Chow P.S., Tan R.B.H. Seeding and constant-supersaturation control by ATR-FTIR in anti-solvent crystallization. Org. Process Res. Dev. 2006, 10:717-722.
25. Zhou G.X., Fujiwara M., Woo X.Y., Rusli E., Tung H.H., Starbuck C., Davidson O., Ge Z.H., Braatz R.D. Direct design of pharmaceutical antisolvent crystallization through concentration control. Cryst. Growth Des. 2006, 6:892-898.
26. Zoltan K.N. Model based robust control approach for batch crystallization product design. Comput. Chem. Eng. 2009, 33:1685-1691.