Cerebrovascular reserve: The link between fitness and cognitive function?

Exercise and Sport Sciences Reviews

Volumn 40, Issue 3, 2012, Pages 153-158

  Davenport, Margie H ^a   Hogan, David B ^a   Eskes, Gail A ^b   Longman, R Stewart ^a   Poulin, Marc J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

aging; brain; cognitive function; exercise; vascular function

Indexed keywords

AGING; ARTICLE; BRAIN CIRCULATION; COGNITION; EXERCISE; HUMAN; PHYSIOLOGY;

AGING; CEREBROVASCULAR CIRCULATION; COGNITION; EXERCISE; HUMANS;

EID: 84862846930     PISSN: 00916331     EISSN: None     Source Type: Journal    
DOI: 10.1097/JES.0b013e3182553430     Document Type: Article

References (40)

1. Ainslie PN, Cotter JD, George KP, et al. Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. J. Physiol. 2008 586(16) 4005-10.
2. Albert MS, Jones K, Savage CR, et al. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol. Aging 1995; 10(4):578-89.
3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington (DC): American Psychiatric Association; 2000.
4. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature 2010; 468(7321):232-43.
5. Brown AD, McMorris CA, Longman RS, et al. Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women. Neurobiol. Aging 2010; 31(12):2047-57.
6. Cheng A, Wang S, Cai J, Rao MS, Mattson MP. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev. Biol. 2003; 258(2):319-33.
7. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychol. Sci. 2003; 14(2):125-30.
8. Colcombe SJ, Erickson KI, Scalf PE, et al. Aerobic exercise training increases brain volume in aging humans. J. Gerontol. A Biol. Sci. Med. Sci. 2006; 61(11):1166-70.
9. Colley RC, Garriguet D, Janssen I, Craig CL, Clarke J, Tremblay MS. Physical activity of Canadian adults: Accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health Rep. 2011; 22(1):7-14.
10. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30(9):464-72.
11. Durrant JR, Seals DR, Connell ML, et al. Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J. Physiol. 2009; 587(Pt 13): 3271-85.
12. Endres M, Gertz K, Lindauer U, et al. Mechanisms of stroke protection by physical activity. Ann. Neurol. 2003; 54(5):582-90.
13. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U. S. A. 2011; 108(7):3017-22.
14. Eskes GA, Longman S, Brown AD, et al. Contribution of physical fitness, cerebrovascular reserve and cognitive stimulation to cognitive function in postmenopausal women. Front. Aging Neurosci. 2010; 2:137.
15. Galvin SD, Celi LA, Thomas KN, et al. Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesth. Intensive Care 2010; 38(4):710-7.
16. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nat. Rev. Immunol. 2011; 11(9):607-15.
17. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J. Appl. Physiol. 2006; 100(3):1059-64.
18. Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: A systematic review of prospective evidence. Psychol. Med. 2009; 39(1):3-11.
19. Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: Exercise effects on brain and cognition. Nat. Rev. Neurosci. 2008; 9(1):58-65.
20. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 2004; 5(5):347-60.
21. Ide K, Worthley M, Anderson T, Poulin MJ. Effects of the nitric oxide synthase inhibitor L-NMMA on cerebrovascular and cardiovascular responses to hypoxia and hypercapnia in humans. J. Physiol. 2007; 584(Pt 1):321-32.
22. Kramer AF, Erickson KI. Capitalizing on cortical plasticity: Influence of physical activity on cognition and brain function. Trends. Cogn. Sci. 2007; 11(8):342-8.
23. Lavi S, Gaitini D, Milloul V, Jacob G. Impaired cerebral CO2 vasoreactivity: Association with endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2006; 291(4):H1856-61.
24. Middleton LE, Manini TM, Simonsick EM, et al. Activity energy expenditure and incident cognitive impairment in older adults. Arch. Intern. Med. 2011; 171(14):1251-7.
25. Mohtasib RS, Lumley G, Goodwin JA, Emsley HC, Sluming V, Parkes LM. Calibrated fMRI during a cognitive Stroop task reveals reduced metabolic response with increasing age. Neuroimage 2012; 59(2):1143-51.
26. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: Mechanisms in search of treatments. Neuron 2010; 67(2):181-98.
27. Panczel G, Daffertshofer M, Ries S, Spiegel D, Hennerici M. Age and stimulus dependency of visually evoked cerebral blood flow responses. Stroke 1999; 30(3):619-23.
28. Pialoux V, Brown AD, Leigh R, Friedenreich CM, Poulin MJ. Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women. Hypertension 2009; 54(5):1014-20.
29. Rovio S, Kareholt I, Helkala EL, et al. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005; 4(11):705-11.
30. Salthouse TA. Selective review of cognitive aging. J. Int. Neuropsychol. Soc. 2010; 16(5):754-60.
31. Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials. Psychosom. Med. 2010; 72(3):239-52.
32. Stoquart-ElSankari S, Baledent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME. Aging effects on cerebral blood and cerebrospinal fluid flows. J. Cereb. Blood Flow Metab. 2007; 27(9):1563-72.
33. Swain R, Harris A, Wiener E, et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 2003; 117(4):1037-46.
34. Thompson BG, Pluta RM, Girton ME, Oldfield EH. Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. J. Neurosurg. 1996; 84(1):71-8.
35. Ungvari Z, Kaley G, de CR, Sonntag WE, Csiszar A. Mechanisms of vascular aging: New perspectives. J. Gerontol. A Biol. Sci. Med. Sci. 2010; 65(10):1028-41.
36. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur. J. Neurosci. 2004; 20(10):2580-90.
37. Vercambre MN, Grodstein F, Manson JE, Stampfer MJ, Kang JH. Physical activity and cognition in women with vascular conditions. Arch. Intern. Med. 2011; 171(14):1244-50.
38. White RP, Deane C, Vallance P, Markus HS. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. Stroke 1998; 29(2):467-72.
39. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: Women who walk. Arch. Intern. Med. 2001; 161(14):1703-8.
40. Yaffe K, Fiocco AJ, Lindquist K, et al. Predictors of maintaining cognitive function in older adults: The Health ABC study. Neurology 2009; 72(23):2029-35.