Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

International Journal of Oncology

Volumn 41, Issue 1, 2012, Pages 253-259

  Yokobori, Takehiko ^a,b   Mimori, Koshi ^a   Iwatsuki, Masaaki ^a   Ishii, Hideshi ^a   Tanaka, Fumiaki ^a   Sato, Tetsuya ^c   Toh, Hiroyuki ^c   Sudo, Tomoya ^a   Iwaya, Takeshi ^a   Tanaka, Yoichi ^d   Onoyama, Ichiro ^a   Kuwano, Hiroyuki ^b   Nakayama, Keiichi I ^a   Mori, Masaki ^e  

^a KYUSHU UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d Saitama Prefectural Cancer Center   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Esophageal squamous cell carcinoma; FBXW7; Myc

Indexed keywords

BETA ACTIN; MESSENGER RNA; MYC PROTEIN; SMALL INTERFERING RNA;

AGED; ARTICLE; CANCER CELL CULTURE; CANCER PATIENT; CELL CYCLE REGULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FBXW7 GENE; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE REPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KAPLAN MEIER METHOD; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

AGED; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER VARIATIONS; ESOPHAGEAL NEOPLASMS; F-BOX PROTEINS; FEMALE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MULTIVARIATE ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; UBIQUITIN-PROTEIN LIGASES;

EID: 84862835658     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1436     Document Type: Article

References (28)

1. Kato H, Fukuchi M, Miyazaki T, et al: Surgical treatment for esophageal cancer. Current issues. Dig Surg 24: 88-95, 2007. (Pubitemid 46788273)
2. Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med 349: 2241-2252, 2003. (Pubitemid 37485141)
3. Mandard AM, Hainaut P and Hollstein M: Genetic steps in the development of squamous cell carcinoma of the esophagus. Mutat Res 462: 335-342, 2000. (Pubitemid 30190239)
4. Soucek L, Whitfield J, Martins CP, et al: Modelling Myc inhibition as a cancer therapy. Nature 455: 679-683, 2008.
5. Nakayama KI and Nakayama K: Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 16: 323-333, 2005.
6. Nakayama KI and Nakayama K: Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6: 369-381, 2006.
7. Onoyama I, Tsunematsu R, Matsumoto A, et al: Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204: 2875-2888, 2007. (Pubitemid 350179557)
8. Welcker M and Clurman BE: FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83-93, 2008. (Pubitemid 351161321)
9. Mao JH, Perez-Losada J, Wu D, et al: Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432: 775-779, 2004. (Pubitemid 39656299)
10. Akhoondi S, Sun D, von der Lehr N, et al: FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67: 9006-9012, 2007. (Pubitemid 47535882)
11. Hagedorn M, Delugin M, Abraldes I, et al: FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients. Cell Div 2: 9, 2007.
12. Bredel M, Bredel C, Juric D, et al: Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res 65: 8679-8689, 2005. (Pubitemid 41377355)
13. Iwatsuki M, Mimori K, Ishii H, et al: Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance. Int J Cancer 126: 1828-1837, 2010.
14. Yokobori T, Mimori K, Iwatsuki M, et al: p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 69: 3788-3794, 2009.
15. Akhoondi S, Lindstrom L, Widschwendter M, et al: Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res 12: R105, 2010.
16. Yen CC, Chen YJ, Chen JT, et al: Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer 92: 2769-2777, 2001.
17. Ieta K, Ojima E, Tanaka F, et al: Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. Int J Cancer 121: 33-38, 2007. (Pubitemid 46753848)
18. Ieta K, Tanaka F, Utsunomiya T, Kuwano H and Mori M: CEACAM6 gene expression in intrahepatic cholangiocarcinoma. Br J Cancer 95: 532-540, 2006. (Pubitemid 44232564)
19. Shimada Y, Imamura M, Wagata T, Yamaguchi N and Tobe T: Characterization of 21 newly established esophageal cancer cell lines. Cancer 69: 277-284, 1992.
20. Ogawa K, Utsunomiya T, Mimori K, et al: Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer. Clin Cancer Res 11: 2889-2893, 2005. (Pubitemid 40525189)
21. Yokobori T, Mimori K, Ishii H, et al: Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer. Ann Surg Oncol 17: 2601-2607, 2010.
22. Nishida K, Mine S, Utsunomiya T, et al: Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and a cDNA microarray. Cancer Res 65: 401-409, 2005.
23. Venkatraman ES and Olshen AB: A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics 23: 657-663, 2007. (Pubitemid 46554715)
24. Quackenbush J: Microarray data normalization and transformation. Nat Genet 32 (Suppl): 496-501, 2002.
25. Brazma A, Hingamp P, Quackenbush J, et al: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29: 365-371, 2001. (Pubitemid 34326681)
26. Tada K, Oka M, Tangoku A, Hayashi H, Oga A and Sasaki K: Gains of 8q23-qter and 20q and loss of 11q22-qter in esophageal squamous cell carcinoma associated with lymph node metastasis. Cancer 88: 268-273, 2000. (Pubitemid 30051808)
27. Hirasaki S, Noguchi T, Mimori K, et al: BAC clones related to prognosis in patients with esophageal squamous carcinoma: an array comparative genomic hybridization study. Oncologist 12: 406-417, 2007. (Pubitemid 46698718)
28. Mayama T, Fukushige S, Shineha R, Nishihira T, Satomi S and Horii A: Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma. Int J Oncol 17: 245-252, 2000.