Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals

Journal of Immunological Methods

Volumn 377, Issue 1-2, 2012, Pages 15-22

  Park, Chae Gyu ^a   Rodriguez, Anthony ^a   Ueta, Hisashi ^b   Lee, Haekyung ^a   Pack, Maggi ^a   Matsuno, Kenjiro ^b   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

CD205; Conserved epitope; DEC205; Dendritic cells; Monoclonal antibody

Indexed keywords

EPITOPE; HDEC205 HIGG1FC FUSION PROTEIN; HYBRID PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD205; MONOCLONAL ANTIBODY DEC205; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CHO CELL; CONTROLLED STUDY; DENDRITIC CELL; EPITOPE MAPPING; FEMALE; FLOW CYTOMETRY; HAPLORHINI; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNIZATION; LYMPHOID TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SPLEEN;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DENDRITIC CELLS; EPITOPES; HUMANS; IMMUNOHISTOCHEMISTRY; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSFECTION;

MAMMALIA; MUS; RATTUS;

EID: 84862831769     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2011.12.009     Document Type: Article

References (22)

1. Bonifaz L., Bonnyay D., Mahnke K., Rivera M., Nussenzweig M.C., Steinman R.M. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 2002, 196:1627.
2. Bonifaz L.C., Bonnyay D.P., Charalambous A., Darguste D.I., Fujii S., Soares H., Brimnes M.K., Moltedo B., Moran T.M., Steinman R.M. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 2004, 199:815.
3. Bozzacco L., Trumpfheller C., Huang Y., Longhi M.P., Shimeliovich I., Schauer J.D., Park C.G., Steinman R.M. HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC. Eur. J. Immunol. 2010, 40:36.
4. Cheong C., Matos I., Choi J.H., Schauer J.D., Dandamudi D.B., Shrestha E., Makeyeva J.A., Li X., Li P., Steinman R.M., Park C.G. New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells. J. Immunol. Methods 2010, 360:66.
5. Cheong C., Choi J.H., Vitale L., He L.Z., Trumpfheller C., Bozzacco L., Do Y., Nchinda G., Park S.H., Dandamudi D.B., Shrestha E., Pack M., Lee H.W., Keler T., Steinman R.M., Park C.G. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood 2010, 116:3828.
6. Gliddon D.R., Hope J.C., Brooke G.P., Howard C.J. DEC-205 expression on migrating dendritic cells in afferent lymph. Immunology 2004, 111:262.
7. Guo M., Gong S., Maric S., Misulovin Z., Pack M., Mahnke K., Nussenzweig M.C., Steinman R.M. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum. Immunol. 2000, 61:729.
8. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., Nussenzweig M.C. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 2001, 194:769.
9. Idoyaga J., Suda N., Suda K., Park C.G., Steinman R.M. Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1524.
10. Jiang W., Swiggard W.J., Heufler C., Peng M., Mirza A., Steinman R.M., Nussenzweig M.C. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995, 375:151.
11. Kato M., McDonald K.J., Khan S., Ross I.L., Vuckovic S., Chen K., Munster D., MacDonald K.P.A., Hart D.N.J. Expression of human DEC-205 (CD205) multilectin receptor on leukocytes. Int. Immunol. 2006, 18:857.
12. Kronin V., Wu L., Gong S., Nussenzweig M.C., Shortman K. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses. Int. Immunol. 2000, 12:731.
13. Longhi M.P., Trumpfheller C., Idoyaga J., Caskey M., Matos I., Kluger C., Salazar A.M., Colonna M., Steinman R.M. Dendritic cells require a systemic type I interferon response to induce CD4+ Th1 immunity with poly IC as adjuvant. J. Exp. Med. 2009, 206:1589.
14. Mahnke K., Guo M., Lee S., Sepulveda H., Swain S.L., Nussenzweig M., Steinman R.M. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J. Cell Biol. 2000, 151:673.
15. Nagasawa K., Shikina S., Takeuchi Y., Yoshizaki G. Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. Biol. Reprod. 2010, 83:597.
16. Pack M., Trumpfheller C., Thomas D., Park C.G., Granelli-Piperno A., Münz C., Steinman R.M. DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp. Immunology 2007, 123:438.
17. Park C.G., Takahara K., Umemoto E., Yashima Y., Matsubara K., Matsuda Y., Clausen B.E., Inaba K., Steinman R.M. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 2001, 13:1283.
18. Steinman R.M. Decisions about dendritic cells: past, present, and future. Annu. Rev. Immunol. 2012, 30:1.
19. Trumpfheller C., Finke J.S., López C.B., Moran T.M., Moltedo B., Soares H., Huang Y., Schlesinger S.J., Park C.G., Nussenzweig M.C., Granelli-Piperno A., Steinman R.M. Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J. Exp. Med. 2006, 203:607.
20. Trumpfheller C., Caskey M., Nchinda G., Longhi M.P., Mizenina O., Huang Y., Schlesinger S.J., Colonna M., Steinman R.M. The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:2574.
21. Trumpfheller C., Longhi M.P., Caskey M., Idoyaga J., Bozzacco L., Keler T., Schlesinger S.J., Steinman R.M. Dendritic cell-targeted protein vaccines: a novel approach to induce T cell immunity. J. Intern. Med. 2012, 10.1111/j.1365-2796.2011.02496.x.
22. Zhou S., Ueta H., Xu X.D., Shi C., Matsuno K. Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: a role of gut lymph nodes. Int. Immunol. 2008, 20:385.