Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1686-1689

  Liu, Jiwen ^a   Wang, Yingcai ^a   Johnson, Michael G ^a   Li, An Rong ^a   Shen, Wang ^a   Wang, Xuemei ^a   Su, Yongli ^a   Brown, Matthew ^a   Lengerich, Bettina Van ^a   Rickel, Erika ^a   Martin, Tod ^a   Budelsky, Alison ^a   Seitz, Lisa ^a   Danao, Jay ^a   Tang, H Lucy ^a   Collins, Tassie ^a   Medina, Julio C ^a  

^a AMGEN INC   (United States)

Author keywords

Asthma; CRTH2; DP; Dual Antagonist; GPCR; PGD2; SAR

Indexed keywords

AMG 009; AMIDE; BISARYL ETHER; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELL; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELL ANTAGONIST; ETHER DERIVATIVE; G PROTEIN COUPLED RECEPTOR; PHENYLACETIC ACID; PHENYLACETIC ACID DERIVATIVE; PROSTANOID D RECEPTOR; PROSTANOID D RECEPTOR ANTAGONIST; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; REACTION OPTIMIZATION; REDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 84862831554     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.107     Document Type: Article

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