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Volumn 497, Issue 2, 2012, Pages 140-146

Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae

Author keywords

Chemical genetics; MAD2; Paclitaxel; Peloruside; Saccharomyces cerevisiae; Yeast

Indexed keywords

ANTINEOPLASTIC AGENT; CELL PROTEIN; PELORUSIDE A; PROTEIN MAD1; PROTEIN MAD2; TAXOID; TUBULIN; UNCLASSIFIED DRUG;

EID: 84862829651     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.01.072     Document Type: Article
Times cited : (15)

References (35)
  • 1
    • 0027056174 scopus 로고
    • Yeast proteins associated with microtubules in vitro and in vivo
    • Barnes G., Louie K.A., Botstein D. Yeast proteins associated with microtubules in vitro and in vivo. Mol. Biol. Cell 1992, 3:29-47.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 29-47
    • Barnes, G.1    Louie, K.A.2    Botstein, D.3
  • 2
    • 0025597940 scopus 로고
    • BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin
    • Berlin V., Styles C.A., Fink G.R. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J. Cell Biol. 1990, 111:2573-2586.
    • (1990) J. Cell Biol. , vol.111 , pp. 2573-2586
    • Berlin, V.1    Styles, C.A.2    Fink, G.R.3
  • 3
    • 0037177229 scopus 로고    scopus 로고
    • Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules
    • Bode C.J., Gupta M.L., Reiff E.A., Suprenant K.A., Georg G.I., Himes R.H. Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 2002, 41:3870-3874.
    • (2002) Biochemistry , vol.41 , pp. 3870-3874
    • Bode, C.J.1    Gupta, M.L.2    Reiff, E.A.3    Suprenant, K.A.4    Georg, G.I.5    Himes, R.H.6
  • 4
    • 18844407538 scopus 로고    scopus 로고
    • Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast
    • Deutschbauer A.M., et al. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 2005, 169:1915-1925.
    • (2005) Genetics , vol.169 , pp. 1915-1925
    • Deutschbauer, A.M.1
  • 5
    • 25844483288 scopus 로고    scopus 로고
    • Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae
    • Foland T.B., Dentler W.L., Suprenant K.A., Gupta M.L., Himes R.H. Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae. Yeast 2005, 22:971-978.
    • (2005) Yeast , vol.22 , pp. 971-978
    • Foland, T.B.1    Dentler, W.L.2    Suprenant, K.A.3    Gupta, M.L.4    Himes, R.H.5
  • 6
    • 0024348798 scopus 로고
    • The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol
    • Gaber R.F., Copple D.M., Kennedy B.K., Vidal M., Bard M. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 1989, 9:3447-3456.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3447-3456
    • Gaber, R.F.1    Copple, D.M.2    Kennedy, B.K.3    Vidal, M.4    Bard, M.5
  • 7
    • 3442894416 scopus 로고    scopus 로고
    • Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines
    • Gaitanos T.N., et al. Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Res. 2004, 64:5063-5067.
    • (2004) Cancer Res. , vol.64 , pp. 5063-5067
    • Gaitanos, T.N.1
  • 8
    • 0033048778 scopus 로고    scopus 로고
    • Genomic profiling of drug sensitivities via induced haploinsufficiency
    • Giaever G., et al. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 1999, 21:278-283.
    • (1999) Nat. Genet. , vol.21 , pp. 278-283
    • Giaever, G.1
  • 9
    • 0037173615 scopus 로고    scopus 로고
    • Functional profiling of the Saccharomyces cerevisiae genome
    • Giaever G., et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002, 418:387-391.
    • (2002) Nature , vol.418 , pp. 387-391
    • Giaever, G.1
  • 10
    • 9144268287 scopus 로고    scopus 로고
    • Chemogenomic profiling: identifying the functional interactions of small molecules in yeast
    • Giaever G., et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:793-798.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 793-798
    • Giaever, G.1
  • 11
    • 0037975662 scopus 로고    scopus 로고
    • Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin
    • Gupta M.L., Bode C.L., Georg G.L., Himes R.H. Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:6394-6397.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6394-6397
    • Gupta, M.L.1    Bode, C.L.2    Georg, G.L.3    Himes, R.H.4
  • 12
    • 0028842802 scopus 로고
    • Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    • Hardwick K.G., Murray A.W. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 1995, 131:709-720.
    • (1995) J. Cell Biol. , vol.131 , pp. 709-720
    • Hardwick, K.G.1    Murray, A.W.2
  • 13
    • 0037096807 scopus 로고    scopus 로고
    • Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity
    • Hood K.A., et al. Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity. Cancer Res. 2002, 62:3356-3360.
    • (2002) Cancer Res. , vol.62 , pp. 3356-3360
    • Hood, K.A.1
  • 14
    • 42649104801 scopus 로고    scopus 로고
    • A unique mode of microtubule stabilization induced by Peloruside A
    • 31
    • Huzil J.T., et al. A unique mode of microtubule stabilization induced by Peloruside A. J. Mol. Biol. 2008, 378:1016-1030. 31.
    • (2008) J. Mol. Biol. , vol.378 , pp. 1016-1030
    • Huzil, J.T.1
  • 15
    • 26444449908 scopus 로고    scopus 로고
    • Low concentrations of Taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy
    • Ikui A.E., Yang C.P.H., Matsumoto T., Horwitz S.B. Low concentrations of Taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle 2005, 4:1385-1388.
    • (2005) Cell Cycle , vol.4 , pp. 1385-1388
    • Ikui, A.E.1    Yang, C.P.H.2    Matsumoto, T.3    Horwitz, S.B.4
  • 16
    • 31844436264 scopus 로고    scopus 로고
    • Yeast ABC transporters - a tale of sex, stress, drugs and aging
    • Jungwirt H., Kuchler K. Yeast ABC transporters - a tale of sex, stress, drugs and aging. FEBS Lett. 2006, 580:1131-1138.
    • (2006) FEBS Lett. , vol.580 , pp. 1131-1138
    • Jungwirt, H.1    Kuchler, K.2
  • 17
    • 80051599729 scopus 로고    scopus 로고
    • Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes
    • Kanakkanthara A., et al. Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. Mol. Cancer Ther. 2011, 10:1419-1429.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1419-1429
    • Kanakkanthara, A.1
  • 18
    • 10244251532 scopus 로고    scopus 로고
    • Identification of a human mitotic checkpoint gene: hsMAD2
    • Li Y., Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 1996, 274:246-248.
    • (1996) Science , vol.274 , pp. 246-248
    • Li, Y.1    Benezra, R.2
  • 19
    • 0026009964 scopus 로고
    • Feedback control of mitosis in budding yeast
    • Li R., Murray A.W. Feedback control of mitosis in budding yeast. Cell 1991, 66:519-531.
    • (1991) Cell , vol.66 , pp. 519-531
    • Li, R.1    Murray, A.W.2
  • 20
    • 10744225364 scopus 로고    scopus 로고
    • Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
    • Lum P.Y., et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 2004, 116:121-137.
    • (2004) Cell , vol.116 , pp. 121-137
    • Lum, P.Y.1
  • 21
    • 18044372415 scopus 로고    scopus 로고
    • Yeast as a model for medical and medicinal research
    • Mager W.H., Winderickx J. Yeast as a model for medical and medicinal research. Trends Pharmacol. Sci. 2005, 26:265-273.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 265-273
    • Mager, W.H.1    Winderickx, J.2
  • 22
    • 34447103991 scopus 로고    scopus 로고
    • Yeast on drugs: Saccharomyces cerevisiae as a tool for anticancer drug research
    • Menacho-Marquez M., Murguia J.R. Yeast on drugs: Saccharomyces cerevisiae as a tool for anticancer drug research. Clin. Transl. Oncol. 2007, 9:221-228.
    • (2007) Clin. Transl. Oncol. , vol.9 , pp. 221-228
    • Menacho-Marquez, M.1    Murguia, J.R.2
  • 24
    • 34247576792 scopus 로고    scopus 로고
    • Chemical genomic tools for understanding gene function and drug action
    • Nislow C., Giaever G. Chemical genomic tools for understanding gene function and drug action. Meth. Microbiol. 2007, 36:387-414.
    • (2007) Meth. Microbiol. , vol.36 , pp. 387-414
    • Nislow, C.1    Giaever, G.2
  • 25
    • 0024549504 scopus 로고
    • Suppressors of yeast actin mutations
    • Novick P., Osmond B.C., Botstein D. Suppressors of yeast actin mutations. Genetics 1989, 121:659-674.
    • (1989) Genetics , vol.121 , pp. 659-674
    • Novick, P.1    Osmond, B.C.2    Botstein, D.3
  • 26
    • 0031581815 scopus 로고    scopus 로고
    • Acquisition of Taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells
    • Parekh H., Wiesen K., Simpkins H. Acquisition of Taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells. Biochem. Pharmacol. 1997, 53:461-470.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 461-470
    • Parekh, H.1    Wiesen, K.2    Simpkins, H.3
  • 27
    • 0347473810 scopus 로고    scopus 로고
    • Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
    • Parsons A.B., et al. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat. Biotechnol. 2004, 22:62-69.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 62-69
    • Parsons, A.B.1
  • 28
    • 33746753342 scopus 로고    scopus 로고
    • Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
    • Parsons A.B., et al. Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 2006, 126:611-625.
    • (2006) Cell , vol.126 , pp. 611-625
    • Parsons, A.B.1
  • 29
    • 39149125171 scopus 로고    scopus 로고
    • Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures
    • Pierce S.E., Davis R.W., Nislow C., Giaever G. Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat. Protoc. 2007, 2:2958-2974.
    • (2007) Nat. Protoc. , vol.2 , pp. 2958-2974
    • Pierce, S.E.1    Davis, R.W.2    Nislow, C.3    Giaever, G.4
  • 30
    • 0022819847 scopus 로고
    • Genetically essential and nonessential α-tubulin genes specify functionally interchangeable proteins
    • Schatz P.J., Solomon F., Botstein D. Genetically essential and nonessential α-tubulin genes specify functionally interchangeable proteins. Mol. Cell. Biol. 1986, 6:3722-3733.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3722-3733
    • Schatz, P.J.1    Solomon, F.2    Botstein, D.3
  • 31
    • 0034723214 scopus 로고    scopus 로고
    • Peloruside A: a potent cytotoxic macrolide isolated from the New Zealand sponge Mycale sp
    • West L.M., Northcote P.T., Battershill C.N. Peloruside A: a potent cytotoxic macrolide isolated from the New Zealand sponge Mycale sp. J. Org. Chem. 2000, 65:445-449.
    • (2000) J. Org. Chem. , vol.65 , pp. 445-449
    • West, L.M.1    Northcote, P.T.2    Battershill, C.N.3
  • 32
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst A.W., et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007, 446:815-819.
    • (2007) Nature , vol.446 , pp. 815-819
    • Whitehurst, A.W.1
  • 33
    • 79959726944 scopus 로고    scopus 로고
    • Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells
    • Wilmes A., et al. Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells. Invest. New Drugs 2011, 29:544-553.
    • (2011) Invest. New Drugs , vol.29 , pp. 544-553
    • Wilmes, A.1
  • 34
    • 84863011555 scopus 로고    scopus 로고
    • Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A
    • Wilmes A., Chan A., Rawson P., Jordan T.W., Miller J.H. Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A. Invest. New Drugs 2012, 30:121-129.
    • (2012) Invest. New Drugs , vol.30 , pp. 121-129
    • Wilmes, A.1    Chan, A.2    Rawson, P.3    Jordan, T.W.4    Miller, J.H.5
  • 35
    • 0033529707 scopus 로고    scopus 로고
    • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
    • Winzeler E.A., et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999, 285:901-906.
    • (1999) Science , vol.285 , pp. 901-906
    • Winzeler, E.A.1


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