Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator

Journal of Clinical Pathology

Volumn 65, Issue 4, 2012, Pages 309-314

  Wu, Li Ching ^a   Chen, Li Tzong ^b   Tsai, Yueh Ju ^c   Lin, Chun Mao ^d   Lin, Ching Yih ^e   Tian, Yu Fang ^e   Sheu, Ming Juen ^e   Uen, Yih Huei ^e   Shiue, Yow Ling ^f   Wang, Yu Hui ^g   Yang, Shu Jing ^a,f   Wu, Wen Ren ^f   Li, Shau Hsuan ^c   Iwamuro, Masaya ^h   Kobayasshi, Naoya ^h   Huang, Hsuan Ying ^c   Li, Chien Feng ^a,b,f,i  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e Chi Mei Foundational Medical Center   (Taiwan)

^f NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^g NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^h OKAYAMA UNIVERSITY   (Japan)

ⁱ SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SPECIFIC SURVIVAL; FEMALE; GALLBLADDER CARCINOMA; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROGNOSIS; RACEMASES AND EPIMERASES; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84862826246     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2011-200489     Document Type: Article

References (31)

1. Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer 1992;70:1493-7.
2. Kapoor VK, McMichael AJ. Gallbladder cancer: an 'Indian' disease. Natl Med J India 2003;16:209-13. (Pubitemid 37304502)
3. Li SH, Li CF, Sung MT, et al. Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray. Mod Pathol 2007;20:497-507.
4. Malka D, Boige V, Dromain C, et al. Biliary tract neoplasms: update 2003. Curr Opin Oncol 2004;16:364-71. (Pubitemid 38870043)
5. Liu Y. Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis 2006;9:230-4. (Pubitemid 44317255)
6. Lloyd MD, Darley DJ, Wierzbicki AS, et al. Alpha-methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS J 2008;275:1089-102. (Pubitemid 351342223)
7. Rubin MA, Zhou M, Dhanasekaran SM. Alpha-methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA 2002;287:1662-70. (Pubitemid 34289218)
8. Zha S, Ferdinandusse S, Denis S, et al. Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer. Cancer Res 2003;63:7365-76. (Pubitemid 37413478)
9. Gunia S, May M, Scholmann K, et al. Expression of alpha-methylacyl-CoA racemase correlates with histopathologic grading in noninvasive bladder cancer. Virchows Arch 2008;453:165-70.
10. Dorer R, Odze RD. AMACR immunostaining is useful in detecting dysplastic epithelium in Barrett's esophagus, ulcerative colitis, and Crohn's disease. Am J Surg Pathol 2006;30:871-7. (Pubitemid 44264978)
11. Sonwalkar SA, Rotimi O, Scott N, et al. A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase). Histopathology 2010;56:900-7.
12. Allory Y, Bazille C, Vieillefond A, et al. Profiling and classification tree applied to renal epithelial tumours. Histopathology 2008;52:158-66.
13. Zhang X, Leav I, Revelo MP, et al. Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PLoS Genet 2009;5:1-15.
14. Lee WA. Alpha-methylacyl-CoA-racemase expression in adenocarcinoma, dysplasia and non-neoplastic epithelium of the stomach. Oncology 2006;71:246-50.
15. Jiang Z, Fanger GR, Woda BA. Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: a study of 761 cases. Hum Pathol 2003;34:792-6. (Pubitemid 37040616)
16. Edge SB, Byrd DR, Compton CC, et al, eds. AJCC Cancer Staging Manual, 7th edn. New York, NY: Springer, 2010.
17. Li CF, Huang WW, Lin CN, et al. Overexpression of fatty acid synthase in gallbladder carcinoma is an independent marker for poor survival. Mod Pathol 2006;19(Suppl 1):112A.
18. Shilo K, Dracheva T, Mani H, et al. Alpha-methylacyl CoA racemase in pulmonary adenocarcinoma, squamous cell carcinoma, and neuroendocrine tumors: expression and survival analysis. Arch Pathol Lab Med 2007;131:1555-60. (Pubitemid 47606721)
19. Miller G, Socci ND, Dhall D, et al. Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract. J Exp Clin Cancer Res 2009;28:62.
20. Progenetix Database. Subest C23:Gallbladder. http://www.progenetix.org/ cgi-bin/ pgSubsetindexLoader.cgi?subIDsearch=LC23&project= (accessed 16 Jan 2011).
21. Sanada T, Yokoi S, Arii S, et al. Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers. Cancer Sci 2004;95:969-76. (Pubitemid 40089589)
22. Zhang P, Liu W, Zhang J, et al. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. Mol Biol Rep 2010;37:1505-12.
23. Mobley JA, Leav I, Zielie P, et al. Branched fatty acids in dairy and beef products markedly enhance a-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer Epidemiol Biomarkers Prev 2003;12:775-83. (Pubitemid 36993169)
24. Wright JL, Neuhouser ML, Lin DW, et al. AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk. Prostate 2011;71:498-506.
25. Daugherty SE, Platz EA, Shugart YY, et al. Variants in the alpha-methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Cancer Epidemiol Biomarkers Prev 2007;16:1536-42. (Pubitemid 47294816)
26. Ferdinandusse S, Denis S, Clayton PT, et al. Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. Nat Genet 2000;24:188-91. (Pubitemid 30094723)
27. Clayton PT. Clinical consequences of defects in peroxisomal b-oxidation. Biochem Soc Trans 2001;29:298-305. (Pubitemid 32587521)
28. Savolainen K, Kotti TJ, Schmitz W, et al. A mouse model for R-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids. Hum Mol Genet 2004;13:955-65. (Pubitemid 38628431)
29. Carnell AJ, Hale I, Denis S, et al. Design, synthesis, and in vitro testing of alpha-methylacyl- CoA racemase inhibitors. J Med Chem 2007;50:2700-7. (Pubitemid 46896078)
30. Woodman TJ, Wood PJ, Thompson AS, et al. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S) - a potential mechanism for the anti-cancer effects of ibuprofen. Chem Commun (Camb) 2011;47:7332-4.
31. Wilson BA, Wang H, Nacev BA, et al. High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S). Mol Cancer Ther 2011;10:825-38.