Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord

NeuroReport

Volumn 23, Issue 6, 2012, Pages 378-384

  Kao, Sheng Chin ^a,b,c   Zhao, Xiuli ^a   Lee, Chun Yi ^a,d   Atianjoh, Fidelis E ^a   Gauda, Estelle B ^a   Yaster, Myron ^a   Tao, Yuan Xiang ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

opioid receptor; astrocyte; expression; microglial cells; morphine tolerance; spinal cord

Indexed keywords

CELL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; IBA1 PROTEIN; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DENSITY; GENE EXPRESSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUMBAR SPINAL CORD; MALE; MICROGLIA; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ANIMALS; ASTROCYTES; CALCIUM-BINDING PROTEINS; DRUG TOLERANCE; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MICROFILAMENT PROTEINS; MICROGLIA; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; RNA, MESSENGER; SPINAL CORD;

EID: 84862826121     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283522e1b     Document Type: Article

References (21)

1. Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, et al. Opioid complications and side effects. Pain Physician 2008; 11:S105-S120. (Pubitemid 351682081)
2. Watkins LR, Hutchinson MR, Milligan ED, Maier SF.Listening and talking to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev 2007; 56:148-169. (Pubitemid 350100866)
3. Horvath RJ, DeLeo JA. Morphine enhances microglial migration through modulation of P2XX4 receptor signaling. J Neurosci 2009; 29:998-1005.
4. Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience 2010; 169:843-854.
5. Turchan-Cholewo J, Dimayuga FO, Gupta S, Keller JN, Knapp PE, Hauser KF, et al. Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation. J Neurochem 2009; 108:202-215.
6. Ruzicka BB, Fox CA, Thompson RC, Meng F, Watson SJ, Akil H. Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA. Brain Res Mol Brain Res 1995; 34:209-220.
7. Stiene-Martin A, Knapp PE, Martin K, Gurwell JA, Ryan S, Thornton SR, et al. Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo. Glia 2001; 36:78-88.
8. Horvath RJ, Romero-Sandoval EA, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain 2010; 150:401-413.
9. Kohno T, Ji RR, Ito N, Allchorne AJ, Befort K, Karchewski LA, et al. Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain 2005; 117:77-87. (Pubitemid 41764774)
10. Abbadie C, Lombard MC, Besson JM, Trafton JA, Basbaum AI. Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions. Brain Res 2002; 930:150-162. (Pubitemid 34195638)
11. Liaw WJ, Zhang B, Tao F, Yaster M, Johns RA, Tao YX. Knockdown of spinal cord postsynaptic density protein-95 prevents the development of morphine tolerance in rats. Neuroscience 2004; 123:11-15. (Pubitemid 37518471)
12. Pan YX. Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters. DNA Cell Biol 2005; 24:736-750.
13. Xu JT, Zhao X, Yaster M, Tao YX. Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn. Brain Res 2010; 1336:46-57.
14. Cui Y, Chen Y, Zhi JL, Guo RX, Feng JQ, Chen PX. Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance. Brain Res 2006; 1069:235-243. (Pubitemid 43145918)
15. Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, et al. mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: comparison between etorphine and morphine. Neuroscience 2006; 138:609-619. (Pubitemid 43255569)
16. Sonomura T, Nakamura K, Furuta T, Hioki H, Nishi A, Yamanaka A, et al. Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Eur J Neurosci 2007; 26:3093-3103. (Pubitemid 350135174)
17. Wang H, Wessendorf MW. Equal proportions of small and large DRG neurons express opioid receptor mRNAs. J Comp Neurol 2001; 429: 590-600. (Pubitemid 32011855)
18. Nehme B, Henry M, Mouginot D. Combined fluorescent in situ hybridization and immunofluorescence: limiting factors and a substitution strategy for slide-mounted tissue sections. J Neurosci Methods 2011; 196: 281-288.
19. Raehal KM, Bohn LM. Mu opioid receptor regulation and opiate responsiveness. AAPS J 2005; 7:E587-E591.
20. Gintzler AR, Chakrabarti S. Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules. Life Sci 2006; 79:717-722. (Pubitemid 43975121)
21. Yu L, Xue FS, Li CW, Xu YC, Zhang GH, Liu KP, et al. [N(omega)-nitro- Larginine methyl ester inhibits the up-regulated expression of neuronal nitric oxide synthase/NMDA receptor in the morphine analgesia tolerance rats.]. Sheng Li Xue Bao 2006; 58:593-598.