Identification of B- and T-cell epitopes from glycoprotein B of herpes simplex virus 2 and evaluation of their immunogenicity and protection efficacy

Vaccine

Volumn 30, Issue 19, 2012, Pages 3034-3041

  Liu, Kun ^a   Jiang, Deyu ^a,b   Zhang, Liangyan ^a   Yao, Zhidong ^a   Chen, Zhongwei ^a   Yu, Sanke ^b   Wang, Xiliang ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

B cell epitopes; Cytotoxic CD8 + T cells; GB protein; Herpes simplex virus; Neutralizing antibodies; T cell epitopes

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN B; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 4; NEUTRALIZING ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE RELEASE; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE; VERO CELL; VIRUS NEUTRALIZATION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; HERPES SIMPLEX; HERPESVIRUS 2, HUMAN; IMMUNOGLOBULIN G; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; VIRAL ENVELOPE PROTEINS; VIRUS SHEDDING;

EID: 84862825089     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.10.010     Document Type: Article

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