Epitope mapping of HSV-1 glycoprotein K (gK) reveals a T cell epitope located within the signal domain of gK

Virus Research

Volumn 128, Issue 1-2, 2007, Pages 71-80

  Osorio, Yanira ^a   Mott, Kevin R ^a   Jabbar, Abdul M ^b   Moreno, Alberto ^b   Foster, Timothy P ^c   Kousoulas, Konstantin G ^c   Ghiasi, Homayon ^a  

^a BURNS AND ALLEN RESEARCH INSTITUTE   (United States)

^b EMORY UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

CFSE; CTL; IFN ; MHC; Peptide; Proliferation; T cells

Indexed keywords

AMINO ACID; EPITOPE; GAMMA INTERFERON; GLYCOPROTEIN; GLYCOPROTEIN K; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EPITOPE MAPPING; ESCHERICHIA COLI; FEMALE; HERPES; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SPLEEN CELL; T LYMPHOCYTE; VACCINATION; VIRION; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HERPESVIRUS 1, HUMAN; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN SORTING SIGNALS; RABBITS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SPODOPTERA; T-LYMPHOCYTES; VIRAL PROTEINS;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; MUS; SIMPLEXVIRUS;

EID: 34547869315     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2007.04.007     Document Type: Article

References (50)

1. Ackerman A.L., Kyritsis C., Tampe R., and Cresswell P. Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells. Nat. Immunol. 6 1 (2005) 107-113
2. Bond V.C., and Person S. Fine structure physical map locations of alterations that affect cell fusion in herpes simplex virus type 1. Virology 132 2 (1984) 368-376
3. Borrow P., Lewicki H., Wei X., Horwitz M.S., Peffer N., Meyers H., Nelson J.A., Gairin J.E., Hahn B.H., Oldstone M.B., and Shaw G.M. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3 2 (1997) 205-211
4. Cresswell P., Ackerman A.L., Giodini A., Peaper D.R., and Wearsch P.A. Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol. Rev. 207 (2005) 145-157
5. Debroy C., Pederson N., and Person S. Nucleotide sequence of a herpes simplex virus type 1 gene that causes cell fusion. Virology 145 1 (1985) 36-48
6. Dietz P., Klupp B.G., Fuchs W., Kollner B., Weiland E., and Mettenleiter T.C. Pseudorabies virus glycoprotein K requires the UL20 gene product for processing. J. Virol. 74 11 (2000) 5083-5090
7. Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., and McGeoch D.J. The genome sequence of herpes simplex virus type 2. J. Virol. 72 3 (1998) 2010-2021
8. Foster T.P., Alvarez X., and Kousoulas K.G. Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion. J. Virol. 77 1 (2003) 499-510
9. Foster T.P., and Kousoulas K.G. Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress. J. Virol. 73 10 (1999) 8457-8468
10. Foster T.P., Melancon J.M., Baines J.D., and Kousoulas K.G. The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion. J. Virol. 78 10 (2004) 5347-5357
11. Ghiasi H., Bahri S., Nesburn A.B., and Wechsler S.L. Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins. Invest. Ophthalmol. Vis. Sci. 36 7 (1995) 1352-1360
12. Ghiasi H., Cai S., Slanina S., Nesburn A.B., and Wechsler S.L. Nonneutralizing antibody against the glycoprotein K of herpes simplex virus type-1 exacerbates herpes simplex virus type-1-induced corneal scarring in various virus-mouse strain combinations. Invest. Ophthalmol. Vis. Sci. 38 6 (1997) 1213-1221
13. Ghiasi H., Kaiwar R., Nesburn A.B., Slanina S., and Wechsler S.L. Expression of seven herpes simplex virus type 1 glycoproteins (gB, gC, gD, gE, gG, gH, and gI): comparative protection against lethal challenge in mice. J. Virol. 68 4 (1994) 2118-2126
14. Ghiasi H., Slanina S., Nesburn A.B., and Wechsler S.L. Characterization of baculovirus-expressed herpes simplex virus type 1 glycoprotein K. J. Virol. 68 4 (1994) 2347-2354
15. Guan P., Doytchinova I.A., Zygouri C., and Flower D.R. MHCPred: bringing a quantitative dimension to the online prediction of MHC binding. Appl. Bioinf. 2 1 (2003) 63-66
16. + CTL. J. Immunol. 154 11 (1995) 6140-6156
17. Henderson R.A., Cox A.L., Sakaguchi K., Appella E., Shabanowitz J., Hunt D.F., and Engelhard V.H. Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells. Proc. Natl. Acad. Sci. U.S.A. 90 21 (1993) 10275-10279
18. Hutchinson L., Goldsmith K., Snoddy D., Ghosh H., Graham F.L., and Johnson D.C. Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. J. Virol. 66 9 (1992) 5603-5609
19. Hutchinson L., and Johnson D.C. Herpes simplex virus glycoprotein K promotes egress of virus particles. J. Virol. 69 9 (1995) 5401-5413
20. Hutchinson L., Roop-Beauchamp C., and Johnson D.C. Herpes simplex virus glycoprotein K is known to influence fusion of infected cells, yet is not on the cell surface. J. Virol. 69 7 (1995) 4556-4563
21. Kassim S.H., Rajasagi N.K., Zhao X., Chervenak R., and Jennings S.R. In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses. J. Virol. 80 8 (2006) 3985-3993
22. Klupp B.G., Baumeister J., Dietz P., Granzow H., and Mettenleiter T.C. Pseudorabies virus glycoprotein gK is a virion structural component involved in virus release but is not required for entry. J. Virol. 72 3 (1998) 1949-1958
23. Koelle D.M., Abbo H., Peck A., Ziegweid K., and Corey L. Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions. J. Infect. Dis. 169 5 (1994) 956-961
24. + cytotoxic T cells from two chronically infected chimpanzees. J. Exp. Med. 183 4 (1996) 1761-1775
25. Lee S.P., Thomas W.A., Blake N.W., and Rickinson A.B. Transporter (TAP)-independent processing of a multiple membrane-spanning protein, the Epstein-Barr virus latent membrane protein 2. Eur. J. Immunol. 26 8 (1996) 1875-1883
26. Little S.P., and Schaffer P.A. Expression of the syncytial (syn) phenotype in HSV-1, strain KOS: genetic and phenotypic studies of mutants in two syn loci. Virology 112 2 (1981) 686-702
27. + herpes simplex virus-specific T cells in patients with herpetic stromal keratitis. J. Infect. Dis. 187 4 (2003) 550-558
28. McCracken A.A., and Brodsky J.L. Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD). Bioessays 25 9 (2003) 868-877
29. McGeoch D.J., Cunningham C., McIntyre G., and Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J. Gen. Virol. 72 Pt 12 (1991) 3057-3075
30. McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., and Taylor P. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69 Pt 7 (1988) 1531-1574
31. McGuffin L.J., Bryson K., and Jones D.T. The PSIPRED protein structure prediction server. Bioinformatics 16 4 (2000) 404-405
32. Mo C., and Holland T.C. Determination of the transmembrane topology of herpes simplex virus type 1 glycoprotein K. J. Biol. Chem. 272 52 (1997) 33305-33311
33. Mo C., Suen J., Sommer M., and Arvin A. Characterization of Varicella-Zoster virus glycoprotein K (open reading frame 5) and its role in virus growth. J. Virol. 73 5 (1999) 4197-4207
34. Mustafa A.S., and Shaban F.A. ProPred analysis and experimental evaluation of promiscuous T-cell epitopes of three major secreted antigens of Mycobacterium tuberculosis. Tuberculosis 86 2 (2006) 115-124
35. Nayak D.P., and Jabbar M.A. Structural domains and organizational conformation involved in the sorting and transport of influenza virus transmembrane proteins. Annu. Rev. Microbiol. 43 (1989) 465-501
36. + T cells in exacerbation of corneal scarring in mice. Curr. Eye Res. 29 (2004) 145-151
37. Parker K.C., Bednarek M.A., and Coligan J.E. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J. Immunol. 152 1 (1994) 163-175
38. Pogue-Geile K.L., and Spear P.G. The single base pair substitution responsible for the Syn phenotype of herpes simplex virus type 1, strain MP. Virology 157 1 (1987) 67-74
39. Ramaswamy R., and Holland T.C. In vitro characterization of the HSV-1 UL53 gene product. Virology 186 2 (1992) 579-587
40. Rammensee H., Bachmann J., Emmerich N.P., Bachor O.A., and Stevanovic S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50 3-4 (1999) 213-219
41. Reche P.A., Glutting J.P., Zhang H., and Reinherz E.L. Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. Immunogenetics 56 6 (2004) 405-419
42. Salzwedel K., Johnston P.B., Roberts S.J., Dubay J.W., and Hunter E. Expression and characterization of glycophospholipid-anchored human immunodeficiency virus type 1 envelope glycoproteins. J. Virol. 67 9 (1993) 5279-5288
43. Salzwedel K., West Jr. J.T., Mulligan M.J., and Hunter E. Retention of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum does not redirect virus assembly from the plasma membrane. J. Virol. 72 9 (1998) 7523-7531
44. Seo S.K., Park H.Y., Choi J.H., Kim W.Y., Kim Y.H., Jung H.W., Kwon B., Lee H.W., and Kwon B.S. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J. Immunol. 171 2 (2003) 576-583
45. Singh H., and Raghava G.P. ProPred: prediction of HLA-DR binding sites. Bioinformatics 17 12 (2001) 1236-1237
46. Spear P.G., Sarmiento M., and Manservigi R. The structural proteins and glycoproteins of herpesviruses: a review. IARC Sci. Publ. 24 (1978) 157-167
47. Tsai B., Ye Y., and Rapoport T.A. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell Biol. 3 4 (2002) 246-255
48. Verjans G.M., Feron E.J., Dings M.E., Cornelissen J.G., Van der Lelij A., Baarsma G.S., Osterhaus A.D., and Cornelissen J.G. T cells specific for the triggering virus infiltrate the eye in patients with herpes simplex virus-mediated acute retinal necrosis. J. Infect. Dis. 178 1 (1998) 27-34
49. Wei M.L., and Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 356 6368 (1992) 443-446
50. York I.A., and Rock K.L. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14 (1996) 369-396