An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness

Journal of Pharmaceutical and Biomedical Analysis

Volumn 62, Issue , 2012, Pages 119-128

  Huang, Min ^a,b   Gao, Jian Yi ^c   Zhai, Zhi Gang ^c   Liang, Qiong Lin ^b   Wang, Yi Ming ^b   Bai, Yan Qiang ^c   Luo, Guo An ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TSINGHUA UNIVERSITY   (China)

^c CHINA ASTRONAUT RESEARCH AND TRAINING CENTER   (China)

Author keywords

Caffeine; Combination therapy; HPLC ESI MS; Motion sickness; Promethazine

Indexed keywords

1 METHYLURIC ACID; 1 METHYLXANTHINE; 1,3 DIMETHYLURIC ACID; 1,3,7 TRIMETHYLURIC ACID; 1,9 DIMETHYLURIC ACID; 3 METHYLXANTHINE; 7 METHYLXANTHINE; CAFFEINE; DRUG METABOLITE; ETOFYLLINE; PARAXANTHINE; PROMETHAZINE; THEOBROMINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MOTION SICKNESS; NORMAL HUMAN; PH; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL;

CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HISTAMINE H1 ANTAGONISTS; HUMANS; MOTION SICKNESS; PROMETHAZINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84862823263     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.12.033     Document Type: Article

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