Dl-3n-butylphthalide promotes angiogenesis via the extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase/akt-endothelial nitric oxide synthase signaling pathways

Journal of Cardiovascular Pharmacology

Volumn 59, Issue 4, 2012, Pages 352-362

  Lu, Xi Lin ^a   Luo, Dan ^a   Yao, Xiao Li ^a   Wang, Guang Lei ^b,c   Liu, Zhi Yong ^a   Li, Zhen Xing ^b,c   Li, Wei ^a   Chang, Feng Jun ^a   Wen, Lu ^d   Lee, Simon Ming Yuen ^e   Zhang, Zai Jun ^e   Li, Ling ^a   Zeng, Jin Sheng ^a   Huang, Ru Xun ^a   Pei, Zhong ^a   Ou, Jing Song ^a,d  

^a BEIJING HOSPITAL   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c Key Laboratory of Functional Molecules from Oceanic Microorganisms   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e University of Macau   (Macao)

Author keywords

angiogenesis; dl 3n butylphthalide; endothelial nitric oxide synthase; extracellular signal regulated kinase 1 2; phosphatidylinositol 3 kinase; zebrafish

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; 3 BUTYLPHTHALIDE; BETA ACTIN; CAVTRATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALS; BENZOFURANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; ZEBRAFISH;

EID: 84862823137     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182443e74     Document Type: Article

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