Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2693-2697

  Rice, Kenneth D ^a   Kim, Moon H ^a   Bussenius, Joerg ^a   Anand, Neel K ^a   Blazey, Charles M ^a   Bowles, Owen J ^a   Canne Bannen, Lynne ^a   Chan, Diva S M ^a   Chen, Baili ^a   Co, Erick W ^a   Costanzo, Simona ^a   Defina, Steven C ^a   Dubenko, Larisa ^a   Engst, Stefan ^a   Franzini, Maurizio ^a   Huang, Ping ^a   Jammalamadaka, Vasu ^a   Khoury, Richard G ^a   Klein, Rhett R ^a   Laird, A Douglas ^a   Le, Donna T ^a   Mac, Morrison B ^a   Matthews, David J ^a   Markby, David ^a   Miller, Nicole ^a   Nuss, John M ^a   Parks, Jason J ^a   Tsang, Tsze H ^a   Tsuhako, Amy L ^a   Wang, Yong ^a   Xu, Wei ^a   more..

^a EXELIXIS INC   (United States)

Author keywords

Akt inhibitor; Cancer; p70S6K inhibitor; PI3K pathway; Pyrazolopyrimidine

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; S6 KINASE; UNCLASSIFIED DRUG; XL 418;

ARTICLE; CANCER INHIBITION; DRUG DESIGN; ENZYME INHIBITION; IN VIVO STUDY; NEGATIVE FEEDBACK; NONHUMAN;

ANIMALS; DOGS; ENZYME ACTIVATION; ENZYME INHIBITORS; HAPLORHINI; HUMANS; MICE; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; PYRIDINES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EID: 84862815670     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.011     Document Type: Article

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