Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2283-2286

  Bussenius, Joerg ^a   Anand, Neel K ^a   Blazey, Charles M ^a   Bowles, Owen J ^a   Bannen, Lynne Canne ^a   Chan, Diva S M ^a   Chen, Baili ^a   Co, Erick W ^a   Costanzo, Simona ^a   Defina, Steven C ^a   Dubenko, Larisa ^a   Engst, Stefan ^a   Franzini, Maurizio ^a   Huang, Ping ^a   Jammalamadaka, Vasu ^a   Khoury, Richard G ^a   Kim, Moon H ^a   Klein, Rhett R ^a   Laird, Douglas ^a   Le, Donna T ^a   Mac, Morrison B ^a   Matthews, David J ^a   Markby, David ^a   Miller, Nicole ^a   Nuss, John M ^a   Parks, Jason J ^a   Tsang, Tsze H ^a   Tsuhako, Amy L ^a   Wang, Yong ^a   Xu, Wei ^a   Rice, Kenneth D ^a   more..

^a EXELIXIS INC   (United States)

Author keywords

Cancer; p70S6K inhibitor; PI3K pathway; Pyrazolopyrimidine

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRAZOLOPYRIMIDINE DERIVATIVE; S6 KINASE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG DESIGN; DRUG HALF LIFE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862776966     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.105     Document Type: Article

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