Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2609-2612

  Dudkin, Vadim Y ^a   Rickert, Keith ^a   Kreatsoulas, Constantine ^a   Wang, Cheng ^a   Arrington, Kenneth L ^a   Fraley, Mark E ^a   Hartman, George D ^a   Yan, Yowei ^a   Ikuta, Mari ^a   Stirdivant, Steven M ^a   Drakas, Robert A ^a   Walsh, Eileen S ^a   Hamilton, Kelly ^a   Buser, Carolyn A ^a   Lobell, Robert B ^a   Sepp Lorenzino, Laura ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ATP competitive kinase inhibitors; Cancer therapy; Checkpoint kinase; Chk1 inhibitors; Combination cancer therapy; DNA damage; Molecular dynamics

Indexed keywords

ETHYLENEDIAMINE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDYL AMINOTHIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; WATER STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMIDES; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ETHYLENEDIAMINES; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; WATER;

EID: 84862815655     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.110     Document Type: Article

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