메뉴 건너뛰기




Volumn 56, Issue 3-4, 2012, Pages 168-175

Relaxation of rat thoracic aorta by fibrate drugs correlates with their potency to disturb intracellular calcium of VSMCs

Author keywords

Fibrates; Intracellular calcium; Relaxation; Thoracic aorta; VSMCs

Indexed keywords

BEZAFIBRATE; CALCIUM ION; FENOFIBRIC ACID; GEMFIBROZIL;

EID: 84862809430     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.01.003     Document Type: Article
Times cited : (9)

References (36)
  • 1
    • 0018885168 scopus 로고
    • Steady-state kinetics of bezafibrate and clofibrate in healthy female volunteers
    • Abshagen U., Sporl-Radun S., Marinow J. Steady-state kinetics of bezafibrate and clofibrate in healthy female volunteers. Eur. J. Clin. Pharmacol. 1980, 17:305-308.
    • (1980) Eur. J. Clin. Pharmacol. , vol.17 , pp. 305-308
    • Abshagen, U.1    Sporl-Radun, S.2    Marinow, J.3
  • 2
    • 33244469454 scopus 로고    scopus 로고
    • Benidipine, a calcium channel blocker, regulates proliferation and phenotype of vascular smooth muscle cells
    • Arakawa E., Hasegawa K. Benidipine, a calcium channel blocker, regulates proliferation and phenotype of vascular smooth muscle cells. J. Pharmacol. Sci. 2006, 100:149-156.
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 149-156
    • Arakawa, E.1    Hasegawa, K.2
  • 4
    • 4143075863 scopus 로고    scopus 로고
    • Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study
    • Borghi C., Dormi A., Veronesi M., Sangiorgi Z., Gaddi A. Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study. Am. Heart J. 2004, 148:285-292.
    • (2004) Am. Heart J. , vol.148 , pp. 285-292
    • Borghi, C.1    Dormi, A.2    Veronesi, M.3    Sangiorgi, Z.4    Gaddi, A.5
  • 5
    • 33644823630 scopus 로고    scopus 로고
    • Gemfibrozil decreases atherosclerosis in experimental diabetes in association with a reduction in oxidative stress and inflammation
    • Calkin A.C., Cooper M.E., Jandeleit-Dahm K.A., Allen T.J. Gemfibrozil decreases atherosclerosis in experimental diabetes in association with a reduction in oxidative stress and inflammation. Diabetologia 2006, 49:766-774.
    • (2006) Diabetologia , vol.49 , pp. 766-774
    • Calkin, A.C.1    Cooper, M.E.2    Jandeleit-Dahm, K.A.3    Allen, T.J.4
  • 6
    • 0036851826 scopus 로고    scopus 로고
    • Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies
    • Dzau V.J., Braun-Dullaeus R.C., Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med. 2002, 8:1249-1256.
    • (2002) Nat. Med. , vol.8 , pp. 1249-1256
    • Dzau, V.J.1    Braun-Dullaeus, R.C.2    Sedding, D.G.3
  • 7
    • 12944324801 scopus 로고    scopus 로고
    • Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding
    • eNigro J., Ballinger M.L., Dilley R.J., Jennings G.L., Wight T.N., Little P.J. Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding. Diabetologia 2004, 47:2105-2113.
    • (2004) Diabetologia , vol.47 , pp. 2105-2113
    • eNigro, J.1    Ballinger, M.L.2    Dilley, R.J.3    Jennings, G.L.4    Wight, T.N.5    Little, P.J.6
  • 8
    • 0019490569 scopus 로고
    • Clofibrate and vascular smooth muscle: actions on rabbit aorta preparations
    • Fairhurst A.S., Kent G., Purdy R.E. Clofibrate and vascular smooth muscle: actions on rabbit aorta preparations. Eur. J. Pharmacol. 1981, 72:323-329.
    • (1981) Eur. J. Pharmacol. , vol.72 , pp. 323-329
    • Fairhurst, A.S.1    Kent, G.2    Purdy, R.E.3
  • 9
    • 0028353193 scopus 로고
    • Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica
    • Fisher T.E., Levy S., Kaczmarek L.K. Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica. J. Neurophysiol. 1994, 71:1254-1257.
    • (1994) J. Neurophysiol. , vol.71 , pp. 1254-1257
    • Fisher, T.E.1    Levy, S.2    Kaczmarek, L.K.3
  • 11
    • 33646855387 scopus 로고    scopus 로고
    • Evaluation of the potential for pharmacokinetic interaction between fenofibrate and ezetimibe: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects
    • Gustavson L.E., Schweitzer S.M., Burt D.A., Achari R., Rieser M.J., Edeki T., Chira T., Yannicelli H.D., Kelly M.T. Evaluation of the potential for pharmacokinetic interaction between fenofibrate and ezetimibe: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects. Clin. Ther. 2006, 28:373-387.
    • (2006) Clin. Ther. , vol.28 , pp. 373-387
    • Gustavson, L.E.1    Schweitzer, S.M.2    Burt, D.A.3    Achari, R.4    Rieser, M.J.5    Edeki, T.6    Chira, T.7    Yannicelli, H.D.8    Kelly, M.T.9
  • 12
    • 0033597936 scopus 로고    scopus 로고
    • Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway
    • Hartigan J.A., Johnson G.V. Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway. J. Biol. Chem. 1999, 274:21395-21401.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21395-21401
    • Hartigan, J.A.1    Johnson, G.V.2
  • 13
    • 0037051164 scopus 로고    scopus 로고
    • Myopathy and rhabdomyolysis with lipid-lowering drugs
    • Hodel C. Myopathy and rhabdomyolysis with lipid-lowering drugs. Toxicol. Lett. 2002, 128:159-168.
    • (2002) Toxicol. Lett. , vol.128 , pp. 159-168
    • Hodel, C.1
  • 14
    • 3442876933 scopus 로고    scopus 로고
    • Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration
    • Hollenbeck S.T., Nelson P.R., Yamamura S., Faries P.L., Liu B., Kent K.C. Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration. J. Vasc. Surg. 2004, 40:351-358.
    • (2004) J. Vasc. Surg. , vol.40 , pp. 351-358
    • Hollenbeck, S.T.1    Nelson, P.R.2    Yamamura, S.3    Faries, P.L.4    Liu, B.5    Kent, K.C.6
  • 15
    • 0037649053 scopus 로고    scopus 로고
    • Bezafibrate improves hypertension and insulin sensitivity in humans
    • Kim J.I., Tsujino T., Fujioka Y., Saito K., Yokoyama M. Bezafibrate improves hypertension and insulin sensitivity in humans. Hypertens. Res. 2003, 26:307-313.
    • (2003) Hypertens. Res. , vol.26 , pp. 307-313
    • Kim, J.I.1    Tsujino, T.2    Fujioka, Y.3    Saito, K.4    Yokoyama, M.5
  • 16
    • 18044386346 scopus 로고    scopus 로고
    • [Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype
    • Kip S.N., Hunter L.W., Ren Q., Harris P.C., Somlo S., Torres V.E., Sieck G.C., Qian Q. [Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype. Circ. Res. 2005, 96:873-880.
    • (2005) Circ. Res. , vol.96 , pp. 873-880
    • Kip, S.N.1    Hunter, L.W.2    Ren, Q.3    Harris, P.C.4    Somlo, S.5    Torres, V.E.6    Sieck, G.C.7    Qian, Q.8
  • 17
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • Kyrklund C., Backman J.T., Neuvonen M., Neuvonen P.J. Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin. Pharmacol. Ther. 2003, 73:538-544.
    • (2003) Clin. Pharmacol. Ther. , vol.73 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 18
    • 0037353970 scopus 로고    scopus 로고
    • Beyond lipid-lowering: effects of statins on endothelial nitric oxide
    • Laufs U. Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur. J. Clin. Pharmacol. 2003, 58:719-731.
    • (2003) Eur. J. Clin. Pharmacol. , vol.58 , pp. 719-731
    • Laufs, U.1
  • 20
    • 60749134645 scopus 로고    scopus 로고
    • Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties
    • Liu A., Xie S., Sun H., Gonzalez F.J., Wei X., Dai R. Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties. Toxicol. Appl. Pharmacol. 2009, 235:287-295.
    • (2009) Toxicol. Appl. Pharmacol. , vol.235 , pp. 287-295
    • Liu, A.1    Xie, S.2    Sun, H.3    Gonzalez, F.J.4    Wei, X.5    Dai, R.6
  • 21
    • 79951825491 scopus 로고    scopus 로고
    • Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity
    • Liu A., Yang J., Gonzalez F.J., Cheng G.Q., Dai R. Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity. Chem. Res. Toxicol. 2011, 24:229-237.
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 229-237
    • Liu, A.1    Yang, J.2    Gonzalez, F.J.3    Cheng, G.Q.4    Dai, R.5
  • 22
    • 0344237127 scopus 로고    scopus 로고
    • Calcium orchestrates apoptosis
    • Mattson M.P., Chan S.L. Calcium orchestrates apoptosis. Nat. Cell Biol. 2003, 5:1041-1043.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 1041-1043
    • Mattson, M.P.1    Chan, S.L.2
  • 23
    • 0036228041 scopus 로고    scopus 로고
    • Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells
    • Nigro J., Dilley R.J., Little P.J. Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. Atherosclerosis 2002, 162:119-129.
    • (2002) Atherosclerosis , vol.162 , pp. 119-129
    • Nigro, J.1    Dilley, R.J.2    Little, P.J.3
  • 24
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions
    • Ogilvie B.W., Zhang D., Li W., Rodrigues A.D., Gipson A.E., Holsapple J., Toren P., Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab. Dispos. 2006, 34:191-197.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 25
    • 26044475136 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?
    • Peters J.M., Cheung C., Gonzalez F.J. Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?. J. Mol. Med. 2005, 83:774-785.
    • (2005) J. Mol. Med. , vol.83 , pp. 774-785
    • Peters, J.M.1    Cheung, C.2    Gonzalez, F.J.3
  • 26
    • 77956134224 scopus 로고    scopus 로고
    • Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil
    • Phelps L.E., Peuler J.D. Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil. J. Smooth Muscle Res. 2010, 46:125-142.
    • (2010) J. Smooth Muscle Res. , vol.46 , pp. 125-142
    • Phelps, L.E.1    Peuler, J.D.2
  • 27
    • 0037835467 scopus 로고    scopus 로고
    • Inhibition of oxidized LDL aggregation with the calcium channel blocker amlodipine: role of electrostatic interactions
    • Phillips J.E., Preston Mason R. Inhibition of oxidized LDL aggregation with the calcium channel blocker amlodipine: role of electrostatic interactions. Atherosclerosis 2003, 168:239-244.
    • (2003) Atherosclerosis , vol.168 , pp. 239-244
    • Phillips, J.E.1    Preston Mason, R.2
  • 28
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins H.B., Robins S.J., Collins D., Fye C.L., Anderson J.W., Elam M.B., Faas F.H., Linares E., Schaefer E.J., Schectman G., Wilt T.J., Wittes J. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 1999, 341:410-418.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 29
    • 0031593038 scopus 로고    scopus 로고
    • Vascular smooth muscle cell migration, atherosclerosis, and calcium channel blockers
    • Schachter M. Vascular smooth muscle cell migration, atherosclerosis, and calcium channel blockers. Int. J. Cardiol. 1997, 62(Suppl 2):S85-S90.
    • (1997) Int. J. Cardiol. , vol.62 , Issue.SUPPL. 2
    • Schachter, M.1
  • 31
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara Y., Hirano M., Sato H., Sugiyama Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J. Pharmacol. Exp. Ther. 2004, 311:228-236.
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 32
    • 3242705901 scopus 로고    scopus 로고
    • Batroxobin reduces intracellular calcium concentration and inhibits proliferation of vascular smooth muscle cells
    • Song Q.B., Wei M.J., Duan Z.Q., Zhang H.Q., Schwartz L.B., Xin S.J. Batroxobin reduces intracellular calcium concentration and inhibits proliferation of vascular smooth muscle cells. Chin. Med. J. (Engl) 2004, 117:917-921.
    • (2004) Chin. Med. J. (Engl) , vol.117 , pp. 917-921
    • Song, Q.B.1    Wei, M.J.2    Duan, Z.Q.3    Zhang, H.Q.4    Schwartz, L.B.5    Xin, S.J.6
  • 33
    • 0037075262 scopus 로고    scopus 로고
    • Cerivastatin and reports of fatal rhabdomyolysis
    • Staffa J.A., Chang J., Green L. Cerivastatin and reports of fatal rhabdomyolysis. N. Engl. J. Med. 2002, 346:539-540.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 539-540
    • Staffa, J.A.1    Chang, J.2    Green, L.3
  • 34
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
    • Takemoto M., Liao J.K. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 2001, 21:1712-1719.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 35
    • 23244463712 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade
    • Williams J.M., Zhao X., Wang M.H., Imig J.D., Pollock D.M. Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Hypertension 2005, 46:366-371.
    • (2005) Hypertension , vol.46 , pp. 366-371
    • Williams, J.M.1    Zhao, X.2    Wang, M.H.3    Imig, J.D.4    Pollock, D.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.