A liquid chromatography-tandem mass spectrometry method for the determination of nodularin-R in human plasma and its preliminary clinical application

Clinica Chimica Acta

Volumn 413, Issue 9-10, 2012, Pages 894-900

  Yu, Ying ^a   Xu, Jinhui ^a   Liu, Yuan ^b   Qiao, Shanlei ^a   Chen, Yun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Demographic factors; Human plasma; Immunoassay; Liquid chromatography tandem mass spectrometry; Method validation; Nodularin R

Indexed keywords

NODULARIN; NODULARIN R; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; IMMUNOASSAY; ISOTOPE LABELING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SEASHORE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADOLESCENT; ADULT; AGED; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84862806543     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.01.039     Document Type: Article

References (45)

1. Carmichael W.W., Azevedo S.M., An J.S., et al. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ Health Perspect 2001, 109:663-668.
2. Codd G.A., Metcalf J.S., Ward C.J., et al. Analysis of cyanobacterial toxins by physicochemical and biochemical methods. J AOAC Int 2001, 84:1626-1635.
3. Meriluoto J., Karlsson K., Spoof L. High-throughput screening of ten microcystins and nodularins, cyanobacterial peptide hepatotoxins, by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry. Chromatographia 2004, 59:291-298.
4. Yu H., Man B.K., Chan L.L., et al. Cloud-point extraction of nodularin-R from natural waters. Anal Chim Acta 2004, 509:63-70.
5. Kuiper-Goodman T., Falconer I., Fitzerald J. Toxic Cyanobacteria in Water: A Guide to their Public Health Consequences, Monitoring and Management 1999, E & FN Spon, London.
6. Pearson L., Mihali T., Moffitt M., Kellmann R., Neilan B. On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. Mar Drugs 2010, 8:1650-1680.
7. Vuorinen P.J., Sipia V.O., Karlsson K., et al. Accumulation and effects of nodularin from a single and repeated oral doses of cyanobacterium Nodularia spumigena on flounder (Platichthys flesus L.). Arch Environ Contam Toxicol 2009, 57:164-173.
8. Yoshizawa S., Matsushima R., Watanabe M.F., et al. Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity. J Cancer Res Clin Oncol 1990, 116:609-614.
9. Fladmark K.E., Serres M.H., Larsen N.L., Yasumoto T., Aune T., Doskeland S.O. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon 1998, 36:1101-1114.
10. Runnegar M.T., Jackson A.R., Falconer I.R. Toxicity of the cyanobacterium Nodularia spumigena Mertens. Toxicon 1988, 26:143-151.
11. Kiviranta J., Saario E., Sivonen K., Niemela S.I. Mouse oral toxicity of the cyanobacterium Nodularia spumigena and inhibition of hepatotoxicity by hydrocortisone. Acta Pharm Fenn 1990, 99:69-76.
12. Helsel D.R. Fabricating data: how substituting values for nondetects can ruin results, and what can be done about it. Chemosphere 2006, 65:2434-2439.
13. Sipia V., Kankaanpaa H., Lahti K., Carmichael W.W., Meriluoto J. Detection of nodularin in flounders and cod from the Baltic Sea. Environ Toxicol 2001, 16:121-126.
14. Spoof L., Karlsson K., Meriluoto J. High-performance liquid chromatographic separation of microcystins and nodularin, cyanobacterial peptide toxins, on C18 and amide C16 sorbents. J Chromatogr A 2001, 909:225-236.
15. Maizels M., Budde W.L. A LC/MS method for the determination of cyanobacteria toxins in water. Anal Chem 2004, 76:1342-1351.
16. Neffling M.R., Spoof L., Meriluoto J. Rapid LC-MS detection of cyanobacterial hepatotoxins microcystins and nodularins-comparison of columns. Anal Chim Acta 2009, 653:234-241.
17. Yuan M., Carmichael W.W. Detection and analysis of the cyanobacterial peptide hepatotoxins microcystin and nodularin using SELDI-TOF mass spectrometry. Toxicon 2004, 44:561-570.
18. Delaunay-Bertoncini N., Pichon V., Hennion M.C. Experimental comparison of three monoclonal antibodies for the class-selective immunoextraction of triazines. Correlation with molecular modeling and principal component analysis studies. J Chromatogr A 2003, 999:3-15.
19. Corona G., Elia C., Casetta B., et al. Liquid chromatography tandem mass spectrometry assay for fast and sensitive quantification of estrone-sulfate. Clin Chim Acta 2010, 411:574-580.
20. Hormazbal V., Ostensvika O., Underdala B., Skulbergb O.M. Simultaneous determination of the cyanotoxins anotoxin A, microcystin desmethyl-3-RR, LR, RR and YR in water using liquid chromatography-mass spectrometry. J Liq Chrom Rel Technol 2000, 23:185-196.
21. Karlsson K.M., Spoof L.E., Meriluoto J.A. Quantitative LC-ESI-MS analyses of microcystins and nodularin-R in animal tissue-matrix effects and method validation. Environ Toxicol 2005, 20:381-389.
22. Spoof L., Vesterkvist P., Lindholm T., Meriluoto J. Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr A 2003, 1020:105-119.
23. Karlsson K., Sipia V., Krause E., Meriluoto J., Pflugmacher S. Mass spectrometric detection and quantification of nodularin-R in flounder livers. Environ Toxicol 2003, 18:284-288.
24. Bogialli S., Bruno M., Curini R., Di Corcia A., Lagana A., Mari B. Simple assay for analyzing five microcystins and nodularin in fish muscle tissue: hot water extraction followed by liquid chromatography-tandem mass spectrometry. J Agric Food Chem 2005, 53:6586-6592.
25. Mazur-Marzec H., Spoof L., Kobos J., Plinski M., Meriluoto J. Cyanobacterial hepatotoxins, microcystins and nodularins, in fresh and brackish waters of the Pomeranian Province, northern Poland. Int J Oceanogr Hydrobiol 2008, 8:1-21.
26. McCormack A.L., Somogyi A., Dongre A.R., Wysocki V.H. Fragmentation of protonated peptides: surface-induced dissociation in conjunction with a quantum mechanical approach. Anal Chem 1993, 65:2859-2872.
27. Medja N., Panariti E., Biba N., Duro S., Neziri A. On the Toxic Influence of Cyanotoxins in Carassius carassius Embryo-Larval Development 2010, BALWOIS, Ohrid, Republic of Macedonia.
28. Chen Y., Qiao S., Wang C. Fragmentation of peptides with intra-chain disulfide bonds in triple quadrupole mass spectrometry and its quantitative application to biological samples. Int J Mass Spectrom 2009, 288:68-74.
29. Allis O., Dauphard J., Hamilton B., et al. Liquid chromatography-tandem mass spectrometry application, for the determination of extracellular hepatotoxins in Irish lake and drinking waters. Anal Chem 2007, 79:3436-3447.
30. Daniel Y.A., Turner C., Haynes R.M., Hunt B.J., Dalton R.N. Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry. Br J Haematol 2005, 130:635-643.
31. Chen Y., Qiao S., Wang X., Liu Y. An investigation into fragmentation of hEGF in triple quadrupole mass spectrometry and its quantitative application to human plasma. Int J Mass Spectrom 2010, 295:7-12.
32. Yuan M., Namikoshi M., Otsuki A. Effect of amino acid side-chain on fragmentation of cyclic peptide ions: differences of electrospray ionization/collision-induced decomposition mass spectra of toxic heptapeptide microcystins containing ADMAdda instead of Adda. Eur Mass Spectrom 1998, 4:287-298.
33. Mazur-Marzec H., Meriluoto J., Plinski M., Szafranek J. Characterization of nodularin variants in Nodularia spumigena from the Baltic Sea using liquid chromatography/mass spectrometry/mass spectrometry. Rapid Commun Mass Spectrom 2006, 20:2023-2032.
34. Honkanen R.E., Zwiller J., Moore R.E., et al. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem 1990, 265:19401-19404.
35. Monks N.R., Liu S., Xu Y., Yu H., Bendelow A.S., Moscow J.A. Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther 2007, 6:587-598.
36. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 2003, 75:3019-3030.
37. Yang Y. Development and validation of a high-performance liquid chromatography-tandem mass spectrometric method for quantification of daunorubicin in rat plasma. Talanta 2007, 71:596-604.
38. Zhao B., Shen H., Liu F., et al. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: a case-control study. J Expo Sci Environ Epidemiol 2011, 21:601-608.
39. Sokol R.Z., Berman N. The effect of age of exposure on lead-induced testicular toxicity. Toxicology 1991, 69:269-278.
40. Schick S., Glantz S.A. Sidestream cigarette smoke toxicity increases with aging and exposure duration. Tob Control 2006, 15:424-429.
41. Zhang Y.J., Zhao X.L., Li X.X., Liu C., Zhu L.L. Performance of PAC/PDM composite coagulants for removal of algae from Lake Taihu waters in summer. Water Sci Technol 2010, 62:330-339.
42. Shao K., Gao G., Qin B., et al. Comparing sediment bacterial communities in the macrophyte-dominated and algae-dominated areas of eutrophic Lake Taihu, China. Can J Microbiol 2011, 57:263-272.
43. Chen Y., Pei J. An assessment of a TNF polymorphic marker for the risk of HCV infection: meta-analysis and a new clinical study design. Infect Genet Evol 2009, 9:1356-1363.
44. Kondo F., Ikai Y., Oka H., et al. Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins. Chem Res Toxicol 1992, 5:591-596.
45. Kondo F., Matsumoto H., Yamada S., et al. Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers. Chem Res Toxicol 1996, 9:1355-1359.