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Volumn 879, Issue 22, 2011, Pages 2127-2134
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Development and validation of a highly rapid and sensitive LC-MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma - Application to a pharmacokinetic study in rats
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Author keywords
LC MS MS; Pharmacokinetics; Rat plasma; SZ 685C
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Indexed keywords
AMMONIUM FORMATE;
ANTI-CANCER AGENTS;
AS EXTRACTION;
CHROMATOGRAPHIC SEPARATIONS;
CLINICAL STUDY;
CONCENTRATION RANGES;
ETHYL ACETATES;
INTERNAL STANDARDS;
INTRAVENOUS ADMINISTRATION;
LC/MS/MS;
LIQUID-LIQUID EXTRACTION;
LOWER LIMIT OF QUANTIFICATIONS;
PHARMACOKINETIC STUDIES;
PRE-CLINICAL;
RAPID METHOD;
RAT PLASMA;
RUNTIMES;
SZ-685C;
AMMONIUM COMPOUNDS;
BIOCHEMISTRY;
BODY FLUIDS;
LIQUID CHROMATOGRAPHY;
LIQUIDS;
MASS SPECTROMETRY;
PHARMACOKINETICS;
PLASMAS;
QUALITY CONTROL;
SOLVENT EXTRACTION;
RATS;
ACETIC ACID ETHYL ESTER;
ACETONITRILE;
AMMONIUM FORMATE;
ANTHRAQUINONE;
ANTINEOPLASTIC AGENT;
EMODIN;
METHANOL;
SZ 685C;
UNCLASSIFIED DRUG;
ACCURACY;
ANIMAL EXPERIMENT;
AREA UNDER THE CURVE;
ARTICLE;
CONTROLLED STUDY;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG HALF LIFE;
DRUG ISOLATION;
ELUTION;
FEMALE;
FLOW RATE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
LIMIT OF QUANTITATION;
LIQUID LIQUID EXTRACTION;
MALE;
MAXIMUM PLASMA CONCENTRATION;
NEGATIVE ION ELECTROSPRAY;
NONHUMAN;
PLASMA CONCENTRATION-TIME CURVE;
POSITIVE ION ELECTROSPRAY;
PRIORITY JOURNAL;
QUALITY CONTROL;
QUANTITATIVE ANALYSIS;
RAT;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
VALIDATION STUDY;
ANIMALS;
ANTHRAQUINONES;
ANTINEOPLASTIC AGENTS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DRUG STABILITY;
EMODIN;
FEMALE;
FUNGI;
HYDROGEN-ION CONCENTRATION;
LINEAR MODELS;
MALE;
RATS;
RATS, SPRAGUE-DAWLEY;
REPRODUCIBILITY OF RESULTS;
RHIZOPHORACEAE;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
RATTUS;
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EID: 79959869852
PISSN: 15700232
EISSN: 1873376X
Source Type: Journal
DOI: 10.1016/j.jchromb.2011.05.049 Document Type: Article |
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Times cited : (6)
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References (7)
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