Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members

FEBS Journal

Volumn 279, Issue 6, 2012, Pages 1093-1105

  Porebski, Przemyslaw J ^a,b,c   Klimecka, Maria ^a,c   Chruszcz, Maksymilian ^a,c   Nicholls, Robert A ^a,c,d   Murzyn, Krzysztof ^a,b,c   Cuff, Marianne E ^c,e   Xu, Xiaohui ^c,f   Cymborowski, Marcin ^a,c   Murshudov, Garib N ^g   Savchenko, Alexei ^c,f   Edwards, Aled ^c,f   Minor, Wladek ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c Midwest Center for Structural Genomics   (United States)

^d UNIVERSITY OF YORK   (United Kingdom)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

^g MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

adenosine binding; biotin synthesis pathway; crystal structure; dethiobiotin synthesis; nucleotide recognition

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; DETHIOBIOTIN SYNTHETASE; GUANOSINE TRIPHOSPHATASE; NUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; FRANCISELLA TULARENSIS; HELICOBACTER PYLORI; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN TARGETING; SPECIES DIFFERENTIATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CARBON-NITROGEN LIGASES; CRYSTALLOGRAPHY, X-RAY; HELICOBACTER PYLORI; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); FUNGI; HELICOBACTER PYLORI;

EID: 84862804236     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08506.x     Document Type: Article

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