Rational design of an inhibitor of dethiobiotin synthetase; interaction of 6-hydroxypyrimidin-4(3H)-one with the adenine base binding site

Tetrahedron

Volumn 54, Issue 52, 1998, Pages 15891-15898

  Alexeev, Dmitriy ^a   Baxter, Robert L ^a   Campopiano, Dominic J ^a   McAlpine, Robin S ^a   McIver, Lisa ^a   Sawyer, Lindsay ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

ATP binding site; Biotin biosynthesis; Dethiobiotin synthetase; Enzyme inhibitor; Inhibitor design; Nucleotide protein interaction

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; BIOTIN; ENZYME INHIBITOR; PYRIMIDINONE DERIVATIVE; SYNTHETASE;

ARTICLE; COMPETITIVE INHIBITION; DRUG DESIGN; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

EID: 0032564590     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)00999-5     Document Type: Article

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