Biocompatibility of polymethylmethacrylate resins used in dentistry

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 100 B, Issue 5, 2012, Pages 1444-1450

  Gautam, Rupali ^a   Singh, Raghuwar D ^a   Sharma, Vinod P ^b   Siddhartha, Ramashanker ^a   Chand, Pooran ^a   Kumar, Rakesh ^b  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Biocompatible; Cytotoxic; Dentistry; Leaching; Polymethylmethacrylate

Indexed keywords

BIOCOMPATIBLE; CELL-BASED; CLINICAL EFFECTS; CYTOTOXIC; CYTOTOXIC EFFECTS; HOST RESPONSE; IN-VITRO; ORTHODONTIC APPLIANCES; PMMA RESINS; RESIDUAL MONOMERS; TISSUE COMPATIBILITY; TOXIC SUBSTANCES;

BIOCOMPATIBILITY; CYTOTOXICITY; DENTISTRY; LEACHING; POLYESTERS; POLYMETHYL METHACRYLATES; TISSUE;

RESINS;

MONOMER; PHARMACEUTICAL VEHICLES AND ADDITIVES; POLY(METHYL METHACRYLATE); RESIN;

ALLERGIC REACTION; ANTIMICROBIAL ACTIVITY; BIOCOMPATIBILITY; CARCINOGENICITY; CHEMISTRY; CYTOTOXICITY; DATA BASE; DENTISTRY; DENTURE; GINGIVA; HISTOCOMPATIBILITY; HUMAN; LEACHING; MOUTH MUCOSA; MUTAGENICITY; POLYMERIZATION; REVIEW;

HUMANS; POLYMETHYL METHACRYLATE; PUBMED; RESINS, SYNTHETIC;

EID: 84862803078     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.32673     Document Type: Review

References (84)

1. León BL, Del Bel Cury AA, Rodrigues Garcia RC. Loss of residual monomer from resilient lining materials processed by different methods. Rev Odonto Cienc 2008;23:215-219.
2. Bayraktar G, Guvener B, Bural C, Uresin Y. Influence of polymerization method, curing process, and length of time of storage in water on the residual methyl methacrylate content in dental acrylic resins. J Biomed Mater Res B: Appl Biomater 2006;76:340-345. (Pubitemid 43165392)
3. Urban VM, Machado AL, Vergani CE, Giampaolo ET, Pavarina AC, Almeida FG, Cass QB. Effect of water-bath post-polymerization on the mechanical properties, degree of conversion, and leaching of residual compounds of hard chairside reline resins. Dent Mater 2009;25:662-671.
4. Rawls H. Dental polymers. In: Anusavice KJ, editor. Phillips' Science of Dental Materials, 11th ed., Vol. 7. St. Louis, MO: Elsevier; 2003; pp 143-169.
5. Koran III. Prosthetic applications of polymers. In: Craig R, Powers JM, Powers J, editors. Restorative Dental Materials, 11th ed. (Chapter 21). St. Louis, MO: Mosby; 2002. pp 635-681.
6. Boehncke WH, Schmitt M, Zollner TM, Hensel O. Nail polish allergy: An important differential diagnosis in contact dermatitis. Dtsch Med Wochenschr 1997;122:849-852. (Pubitemid 27302562)
7. Erdmann SM, Sachs B, Merk HF. Adverse reactions to sculptured nails. Allergy 2001;56:581-582. (Pubitemid 32521448)
8. Celebi N, Yuzugullu B, Canay S, Yucel U. Effect of polymerization methods on the residual monomer level of acrylic resin denture base polymers. Polym Adv Technol 2008;19:201-206. (Pubitemid 351523537)
9. Braden M. Some aspects of the chemistry and physics of dental resins. Adv Dent Res 1988;2:93-97.
10. Sawtell M, Downes S, Patel MP, Clarke RL, Braden M. Heterocyclic methacrylates for clinical applications-further studies of water sorption. J Mater Sci Mater Med 1997;8:667-674. (Pubitemid 27485095)
11. Ogle RE, Sorensen SE, Lewis EA. A new visible light-cured resin system applied to removable prosthodontics. J Prosthet Dent 1986;56:497-506.
12. Fletcher AM, Purnaveja S, Amin WM, Ritchie GM, Moradians S, Dodd AW. The level of residual monomer in self curing denture-base materials. J Dent Res 1983;62:118-120. (Pubitemid 13081989)
13. Kedjarune U, Charoenworaluk N, Koontongkaew S. Release of methyl methacrylate from heat-cured and autopolymerized resins: Cytotoxicity testing related to residual monomer. Aust Dent J 1999;44:25-30.
14. Harrison A, Huggett R. Effect of the curing cycle on residual monomer levels of acrylic resin denture base polymers. J Dent 1992;20:370-374.
15. Vallittu PK, Ruyter IE, Buykuilmaz S. Effect of polymerization temperature and time on the residual monomer content of denture base polymers. Eur J Oral Sci 1998;106:588-593. (Pubitemid 128736232)
16. Tsuchiya H, Hoshino Y, Kato H, Takagi N. Flow injection analysis of formaldehyde leached from denture-base acrylic resins. J Dent 1993;21:240-243.
17. Tsuchiya H, Hoshino Y, Tajima K, Takagi N. Leaching and cytotoxicity of formaldehyde and methyl methacrylate from acrylic resin denture base materials. J Prosthet Dent 1994;71:618-624.
18. Cimpan MR, Cressey LI, Skaug N, Halstensen A, Lie SA, Gjertsen BT. Patterns of cell death induced by elutes from denture base acrylic resins in U-937 human monoblastoid cells. Eur J Oral Sci 2000;108:59-69.
19. Cimpan MR, Matre R, Cressey LI, Tysnes B, Lie SA, Gjertsen BT. The effect of heat- and auto-polymerized denture base polymers on clonogenicity, apoptosis, and necrosis in fibroblasts: denture base polymers induce apoptosis and necrosis. Acta Odontol Scand 2000;58:217-228.
20. Yunus N, Harrison A, Huggett R. Effect of microwave irradiation on the flexural strength and residual monomer levels of an acrylic resin repair material. J Oral Rehabil 1994;21:641-648.
21. Blagojevic V, Murphy VM. Microwave polymerization of denture base materials. A comparative study. J Oral Rehabil 1999;26:804-808.
22. De Clerck JP. Microwave polymerization of acrylic resins used in dental prostheses. J Prosthet Dent 1987;57:650-658.
23. Austin AT, Basker RM. The level of residual monomer in acrylic denture base materials with particular reference to a modified method of analysis. Br Dent J 1980;149:281-286.
24. Baker S, Brooks SC, Walker DM. The release of residual monomeric methyl methacrylate from acrylic appliances in human mouth: An assay for monomer in saliva. J Dent Res 1988;67:1295-1299.
25. Sofou A, Tsoupi I, Emmanouil J, Karayannis M. HPLC determination of residual monomers released from heat-cured acrylic resins. Anal Bioanal Chem 2005;381:1336-1346. (Pubitemid 40537604)
26. Jorge JH, Giampaolo ET, Vergani CE, Machado AL, Pavarina AC, Carlos IZ. Effect of post-polymerization heat treatments on the cytotoxicity of two denture base acrylic resins. J Appl Oral Sci 2006;14:203-207. (Pubitemid 44285332)
27. Lygre H, Solheim E, Gjerdet NR. Leaching from denture base materials in vitro. Acta Odontol Scand 1995;53:75-80.
28. Vallittu PK, Miettinen V, Alakuijala P. Residual monomer content and its release into water from denture base materials. Dent Mater 1995;11:338-342.
29. Vallittu PK. The effect of surface treatment of denture acrylic resin on the residual monomer content and its release into water. Acta Odontol Scand 1996;54:188-192. (Pubitemid 126507387)
30. Azzarri MJ, Cortizo MS, Alessandrini JL. Effect of the curing conditions on the properties of an acrylic denture base resin microwave-polymerized. J Dent 2003;31:463-468. (Pubitemid 36961435)
31. Zissis A, Yannikakis S, Polyzois G, Harrison A. A long term study on residual monomer release from denture materials. Eur J Prosthodont Restor Dent 2008;16:81-84.
32. Stafford GD, Brooks SC. The loss of residual monomer from acrylic orthodontic resins. Dent Mater 1985;1:135-138.
33. Nunes de Mello JA, Braun KO, Rached RN, Del Bel Cury AA. Reducing the negative effects of chemical polishing in acrylic resins by use of an additional cycle of polymerization. J Prosthet Dent 2003;89:598-602. (Pubitemid 37304940)
34. Graham BS, Jones DW, Suttow EJ. An in vivo and in vitro study of the loss of plasticizer from soft polymer-gel materials. J Dent Res 1991;70:870-873.
35. Oysaed H, Ruyter IE, Sjøvik Kleven IJ. Release of formaldehyde from dental composites. J Dent Res 1988;67:1289-1294.
36. Kawahara T, Nomura Y, Tanaka N, Teshima W, Okazaki M, Shintani M. Leachability of plasticizer and residual monomer from commercial temporary restorative resins. J Dent 2004;32:277-283. (Pubitemid 38438437)
37. Kawaguchi M, Takahashi Y, Fukushima T, Habu T. Effect of light-exposure duration on the amount of leachable monomers from light-activated reline material. J Prosthet Dent 1996;75:183-187. (Pubitemid 126653660)
38. Boeckler AF, Morton D, Poser S, Dette KE. Release of dibenzoyl peroxide from polymethyl methacrylate denture base resins: An in vitro evaluation. Dent Mater 2008;24:1602-1607.
39. Munksgaard EC. Plasticizers in denture soft-lining materials: leaching and biodegradation. Eur J Oral Sci 2005;113:166-169. (Pubitemid 40592284)
40. Koda T, Tsuchiya H, Yamauchi M, Ohtani S, Takagi N, Kawano J. Leachability of denture-base acrylic resins in artificial saliva. Dent Mater 1990;6:13-16.
41. Brozek R, Rogalewicz R, Koczorowski R, Voelkel A. The influence of denture cleansers on the release of organic compounds from soft lining materials. J Environ Monit 2008;10:770-774. (Pubitemid 351798442)
42. Nakamura M, Kawahara H. Long-term biocompatibility test of denture base resins in vitro. J Prosthet Dent 1984;52:694-699.
43. Imazato S, Horikawa D, Ogata K, Kinomoto Y, Ebisu S. Responses of MC3T3-E1 cells to three dental resin-based restorative materials. J Biomed Mater Res A 2006;76:765-772. (Pubitemid 47233485)
44. Lai YL, Chen YT, Lee SY, Shieh TM, Hung SL. Cytotoxic effects of dental resin liquids on primary gingival fibroblasts and periodontal ligament cells in vitro. J Oral Rehabil 2004;31:1165-1172.
45. Shuster GS, Lefebvre CA, Dirksen TR, Knoernschild KL, Caughmann GB. Relationship between denture base resin cytotoxicity and cell lipid metabolism. Int J Prosthodont 1995;8:580-586.
46. Vale FM, Castro M, Monteiro J, Couto FS, Pinto R, Toscano Rico JMG. Acrylic bone cement induces the production of free radicals by cultured human fibroblasts. Biomaterials 1997;18:1133-1135. (Pubitemid 27342990)
47. Sheridan PJ, Koka S, Ewoldsen NO, Lefebvre CA, Lavin MT. Cytotoxicity of denture base resins. Int J Prosthodont 1997;10:73-77. (Pubitemid 127499565)
48. Borzelleca JF, Larson PS, Hennigar GR, Huf EG, Crawford EM, Smith RB. Studies on the chronic oral toxicity of monomeric ethyl acrylates and methyl methacrylates. Toxicol Appl Pharmacol 1964;6; 29-36.
49. Bereznowski Z. In vivo assessment of methyl methacrylate metabolism and toxicity. Int J Biochem Cell Biol 1995;27:1311-1316.
50. Corkill JA, Lloyd EJ, Hoyle P, Crout DHG, Ling RSM, James ML, Piper RJ. Toxicology of methyl methacrylates: The rate of disappearance of methyl methacrylate in human blood in vitro. Clin Chim Acta 1976;68:141-146.
51. Technische Regel fur Gefahrstoffe: TRGS 900 - Grenzwerte in der Luft am Arbeitsplatz - Luftgrenzwerte. [Technical regulations for hazardous substances: TRGS 900 - Threshold values in air at the work place - threshold values for air] BarbBl. 10/2000 pp 34-63; eingearbeitete Anderungen: 4/2001 p 56; 9/2001 p 86.
52. Hensten-Pettersen A, Jacobsen N. Perceived side effects of biomaterials in prosthetic dentistry. J Prosthet Dent 1991;65:138-144.
53. Hensten-Pettersen A, Wictorin L. The cytotoxic effect of denture base polymers. Acta Odontol Scand 1981;39:101-106. (Pubitemid 11064931)
54. Gough JE, Downes S. Osteoblast cell death on methacrylate polymers involves apoptosis. J Biomed Mater Res 2001;57:497-505. (Pubitemid 32937530)
55. Geurtsen W, Lehmann F, Spahl W, Leyhausen G. Cytotoxicity of 35 dental resin composite monomers/additives in permanent 3T3 and three human primary fibroblast cultures. J Biomed Mater Res 1998;41:474-480. (Pubitemid 28300113)
56. Stea S, Granchi D, Zolezzi C, Ciapetti G, Visentin M, Cavedagna D, Pizzoferrato A. High-performance liquid chromatography assay of N,N-dimethyl-p-toluidine released from bone cements: evidence for toxicity. Biomaterials 1997;18:243-246. (Pubitemid 27064799)
57. Anil N, Hekimoglu C, Buyukba N, Ercan MT. Microleakage study of various soft denture liners by autoradiography: Effect of accelerated aging. J Prosthet Dent 2000;81:394-399.
58. Makila E, Hopsu-Havu VK. Mycotic growth and soft denture lining materials. Acta Odont Scand 1976;35:197-205. (Pubitemid 8178984)
59. Nikawa H, Yamamoto T, Hamada T. Effect of components of resilient denture-lining materials on the growth, acid production and colonization of Candida albicans. J Oral Rehabil 1995;22:817-824.
60. Nikawa H, Hamada T, Yamamoto T, Kumagai H. Effects of salivary or serum pellicles on the Candida albicans growth and biofilm formation on soft lining materials in vitro. J Oral Rehabil 1997;24:594-604. (Pubitemid 127731965)
61. Olan-Rodriguez L, Minah GE, Driscoll CF. Candida albicans colonization of surface-sealed interim soft liners. J Prosthodont 2000;9:184-188.
62. Willershausen B, Callaway A, Ernst CP, Stender E. The influence of oral bacteria on the surfaces of resin-based dental restorative materials: An in vitro study. Int Dent J 1999;49:231-239.
63. Jorge JH, Giampaolo ET, Machado AL, Vergani CE. Cytotoxicity of denture base acrylic resins: a literature review. J Prosthet Dent 2003;90:190-193. (Pubitemid 37304991)
64. Kaaber S. Allergy to dental materials with special reference to the use of amalgam and polymethylmethacrylate. Int Dent J 1990;40:359-365.
65. Ali A, Bates FJ, Reynolds AJ, Walker DM. The burning mouth sensation related to the wearing of acrylic dentures: An investigation. Br Dent J 1986;161:444-447.
66. Kallus T, Mjor IA. Incidence of adverse effects of dental materials. Scand J Dent Res 1991;99:236-240.
67. Kanerva L, Estlander T, Jolanki R. Allergic contact dermatitis from dental composite resins due to aromatic epoxy acrylates and aliphatic acrylates. Contact Dermat 1989;20:201-211. (Pubitemid 19066590)
68. Ohlson CG, Svensson L, Mossberg B, Hok M. Prevalence of contact dermatitis among dental personnel in a Swedish rural county. Swed Dent J 2001;25:13-20. (Pubitemid 33745399)
69. Tschernitschek H, Wolter S, Korner M. Allergien auf Zahnersatz- materialien. [Allergies and prosthetic materials] Dermatosen/Occup Environ 1998;46:244-248.
70. Leyhausen G, Kunert M, Bubeck P, Geurtsen W. Cytocompatibility of ionomer- and resin-based bone cements. J Dent Res 1998;77:119-123.
71. Kanerva L, Estlander T, Jolanki R. Allergic contact dermatitis from dental composite resins due to aromatic epoxy acrylates and aliphatic acrylates. Contact Dermat 1989;20:201-211. (Pubitemid 19066590)
72. Kanerva L, Estlander T, Jolanki R. Occupational skin allergy in the dental profession. Dermatol Clin 1994;12:517-532. (Pubitemid 24260334)
73. Giunta J, Zablotsky N. Allergic stomatitis caused by self-polymerizing resin. Oral Surg Oral Med Oral Pathol 1976;41:631-637.
74. Lunder T, Rogl-Butina M. Chronic urticaria from an acrylic dental prosthesis. Contact Dermat 2000;43:232-233.
75. Leggat PA, Kedjarune U. Toxicity of methylmethacrylate in dentistry. Int Dent J 2003;53:126-131.
76. Gonçalves TS, Morganti MA, Campos LC, Rizzatto SM, Menezes LM. Allergy to auto-polymerized acrylic resin in an orthodontic patient. Am J Orthod Dentofacial Orthop 2006;129:431-435. (Pubitemid 43351124)
77. Aalto-Korte K, Alanko K, Kuuliala O, Jolanki R. Methacrylate and acrylate allergy in dental personnel. Contact Dermat 2007;57:324-330. (Pubitemid 47568794)
78. Oppenheimer BS, Oppenheimer ET, Danishefsky AP, Stout AP, Eirich FR. Further studies of polymers as carcinogenic agents in animals. Cancer Res 1995;15:333-340.
79. Habal MB, Powell RD. Biophysical evaluation of the tumorigenic response to implanted polymers. J Biomed Mat Res 1980;14:447-454. (Pubitemid 10086167)
80. Miller EG, Washington VH, Bowles WH, Zimmermann ER. Mutagenic potential of some chemical components of dental materials. Dent Mater 1986;2:163-165.
81. Mitchell DF, Shankwalker GB, Shazer S. Determining the tumorigenicity of dental materials. J Dent Res 1960;39:1023-1028.
82. Autian J. Structure-toxicity relationships of acrylic monomers. Environ Health Perspect 1975;11:141-152.
83. International Organization for Standardization. Specification 1567: Denture Base Polymers, 2nd ed. Switzerland: ISO; 1999.
84. Att W, Yamada M, Kojima N, Ogawa T. N-acetyl cysteine prevents suppression of oral fibroblast function on poly(methylmethacrylate) resin. Acta Biomater 2009;5:391-398.