Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2330-2337

  Oza, Vibha ^a   Ashwell, Susan ^a   Brassil, Patrick ^a   Breed, Jason ^a   Ezhuthachan, Jaychandran ^a,b   Deng, Chun ^a   Grondine, Michael ^a   Horn, Candice ^a,b   Liu, Dongfang ^a,b   Lyne, Paul ^a   Newcombe, Nicholas ^a   Pass, Martin ^a   Read, Jon ^a   Su, Mei ^a   Toader, Dorin ^a   Yu, Dingwei ^a   Yu, Yan ^a   Zabludoff, Sonya ^a,b  

^a ASTRAZENECA   (United Kingdom)

^b AstraZeneca RandD Alderley Park ^*

Author keywords

Checkpoint kinase 1; CHK1; In vivo activity; Triazolones

Indexed keywords

PROTEIN SERINE THREONINE KINASE INHIBITOR; TOPOTECAN; TRIAZOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; CRYSTALLOGRAPHY, X-RAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOTECAN; TRIAZOLES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862801889     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.043     Document Type: Article

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