-
1
-
-
0034658541
-
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
-
10.1038/sj.onc.1203551, 10851053
-
Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000, 19:2548-2556. 10.1038/sj.onc.1203551, 10851053.
-
(2000)
Oncogene
, vol.19
, pp. 2548-2556
-
-
Hirano, T.1
Ishihara, K.2
Hibi, M.3
-
2
-
-
52949151882
-
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
-
10.1016/j.semcdb.2008.07.011, 2657870, 18708155
-
Wei L, Laurence A, O'Shea JJ. New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol 2008, 19:394-400. 10.1016/j.semcdb.2008.07.011, 2657870, 18708155.
-
(2008)
Semin Cell Dev Biol
, vol.19
, pp. 394-400
-
-
Wei, L.1
Laurence, A.2
O'Shea, J.J.3
-
3
-
-
64849111865
-
Targeting STAT3 in cancer: how successful are we?
-
10.1517/13543780802565791, 2610472, 19053881
-
Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we?. Expert Opin Investig Drugs 2009, 18:45-56. 10.1517/13543780802565791, 2610472, 19053881.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
4
-
-
34247600538
-
STAT3 as a central mediator of neoplastic cellular transformation
-
10.1016/j.canlet.2006.10.017, 17129668
-
Frank DA. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 2007, 251:199-210. 10.1016/j.canlet.2006.10.017, 17129668.
-
(2007)
Cancer Lett
, vol.251
, pp. 199-210
-
-
Frank, D.A.1
-
5
-
-
25444454543
-
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
-
10.4161/cc.4.9.1985, 16082218
-
Inghirami G, Chiarle R, Simmons WJ, Piva R, Schlessinger K, Levy DE. New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell Cycle 2005, 4:1131-1133. 10.4161/cc.4.9.1985, 16082218.
-
(2005)
Cell Cycle
, vol.4
, pp. 1131-1133
-
-
Inghirami, G.1
Chiarle, R.2
Simmons, W.J.3
Piva, R.4
Schlessinger, K.5
Levy, D.E.6
-
6
-
-
38949086516
-
Protein tyrosine phosphatases: regulatory mechanisms
-
10.1111/j.1742-4658.2008.06247.x, 18298791
-
den Hertog J, Ostman A, Bohmer FD. Protein tyrosine phosphatases: regulatory mechanisms. FEBS J 2008, 275:831-847. 10.1111/j.1742-4658.2008.06247.x, 18298791.
-
(2008)
FEBS J
, vol.275
, pp. 831-847
-
-
den Hertog, J.1
Ostman, A.2
Bohmer, F.D.3
-
7
-
-
0036138705
-
A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus
-
10.1210/me.16.1.58, 11773439
-
Aoki N, Matsuda T. A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol 2002, 16:58-69. 10.1210/me.16.1.58, 11773439.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 58-69
-
-
Aoki, N.1
Matsuda, T.2
-
8
-
-
78650210970
-
PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells
-
Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells. Am J Pathol 2010,
-
(2010)
Am J Pathol
-
-
Johnson, K.J.1
Peck, A.R.2
Liu, C.3
Tran, T.H.4
Utama, F.E.5
Sjolund, A.B.6
Schaber, J.D.7
Witkiewicz, A.K.8
Rui, H.9
-
9
-
-
58149148417
-
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
-
10.1182/blood-2008-03-148726, 2582009, 18716132
-
Lu X, Malumbres R, Shields B, Jiang X, Sarosiek KA, Natkunam Y, Tiganis T, Lossos IS. PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood 2008, 112:4098-4108. 10.1182/blood-2008-03-148726, 2582009, 18716132.
-
(2008)
Blood
, vol.112
, pp. 4098-4108
-
-
Lu, X.1
Malumbres, R.2
Shields, B.3
Jiang, X.4
Sarosiek, K.A.5
Natkunam, Y.6
Tiganis, T.7
Lossos, I.S.8
-
10
-
-
0036796060
-
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
-
10.1038/nm763, 12219085
-
Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002, 8:1089-1097. 10.1038/nm763, 12219085.
-
(2002)
Nat Med
, vol.8
, pp. 1089-1097
-
-
Tebbutt, N.C.1
Giraud, A.S.2
Inglese, M.3
Jenkins, B.4
Waring, P.5
Clay, F.J.6
Malki, S.7
Alderman, B.M.8
Grail, D.9
Hollande, F.10
Heath, J.K.11
Ernst, M.12
-
11
-
-
54049124612
-
Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2
-
Baron M, Davignon JL. Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. J Immunol 2008, 181:5530-5536.
-
(2008)
J Immunol
, vol.181
, pp. 5530-5536
-
-
Baron, M.1
Davignon, J.L.2
-
12
-
-
70249114863
-
Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2
-
10.4049/jimmunol.0804033, 19542364
-
Tsai CC, Kai JI, Huang WC, Wang CY, Wang Y, Chen CL, Fang YT, Lin YS, Anderson R, Chen SH, Tsao CW, Lin CF. Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2. J Immunol 2009, 183:856-864. 10.4049/jimmunol.0804033, 19542364.
-
(2009)
J Immunol
, vol.183
, pp. 856-864
-
-
Tsai, C.C.1
Kai, J.I.2
Huang, W.C.3
Wang, C.Y.4
Wang, Y.5
Chen, C.L.6
Fang, Y.T.7
Lin, Y.S.8
Anderson, R.9
Chen, S.H.10
Tsao, C.W.11
Lin, C.F.12
-
13
-
-
0036318564
-
Identification of a nuclear Stat1 protein tyrosine phosphatase
-
10.1128/MCB.22.16.5662-5668.2002, 133976, 12138178
-
ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol 2002, 22:5662-5668. 10.1128/MCB.22.16.5662-5668.2002, 133976, 12138178.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5662-5668
-
-
ten Hoeve, J.1
de Jesus Ibarra-Sanchez, M.2
Fu, Y.3
Zhu, W.4
Tremblay, M.5
David, M.6
Shuai, K.7
-
14
-
-
2442577024
-
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors
-
10.1074/jbc.M400766200, 15010467
-
Meyer T, Hendry L, Begitt A, John S, Vinkemeier U. A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J Biol Chem 2004, 279:18998-19007. 10.1074/jbc.M400766200, 15010467.
-
(2004)
J Biol Chem
, vol.279
, pp. 18998-19007
-
-
Meyer, T.1
Hendry, L.2
Begitt, A.3
John, S.4
Vinkemeier, U.5
-
15
-
-
0037163109
-
Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells
-
10.1074/jbc.M200156200, 12060651
-
Chughtai N, Schimchowitsch S, Lebrun JJ, Ali S. Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. J Biol Chem 2002, 277:31107-31114. 10.1074/jbc.M200156200, 12060651.
-
(2002)
J Biol Chem
, vol.277
, pp. 31107-31114
-
-
Chughtai, N.1
Schimchowitsch, S.2
Lebrun, J.J.3
Ali, S.4
-
17
-
-
40849102641
-
The role and target potential of protein tyrosine phosphatases in cancer
-
10.1007/s11912-008-0019-6, 18377824
-
Yi T, Lindner D. The role and target potential of protein tyrosine phosphatases in cancer. Curr Oncol Rep 2008, 10:114-121. 10.1007/s11912-008-0019-6, 18377824.
-
(2008)
Curr Oncol Rep
, vol.10
, pp. 114-121
-
-
Yi, T.1
Lindner, D.2
-
18
-
-
33748331432
-
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling
-
10.1016/j.cmet.2006.03.006, 16679294
-
Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab 2006, 3:367-378. 10.1016/j.cmet.2006.03.006, 16679294.
-
(2006)
Cell Metab
, vol.3
, pp. 367-378
-
-
Cho, C.Y.1
Koo, S.H.2
Wang, Y.3
Callaway, S.4
Hedrick, S.5
Mak, P.A.6
Orth, A.P.7
Peters, E.C.8
Saez, E.9
Montminy, M.10
Schultz, P.G.11
Chanda, S.K.12
-
19
-
-
84862786310
-
Research progress of several protein tyrosine phosphatases in diabetes
-
Chen M, Sun JP, Liu J, Yu X. Research progress of several protein tyrosine phosphatases in diabetes. Sheng Li Xue Bao 2010, 62:179-189.
-
(2010)
Sheng Li Xue Bao
, vol.62
, pp. 179-189
-
-
Chen, M.1
Sun, J.P.2
Liu, J.3
Yu, X.4
-
20
-
-
77952061964
-
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells
-
10.1074/jbc.M109.099879, 2865303, 20335174
-
Yuan T, Wang Y, Zhao ZJ, Gu H. Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. J Biol Chem 2010, 285:14861-14870. 10.1074/jbc.M109.099879, 2865303, 20335174.
-
(2010)
J Biol Chem
, vol.285
, pp. 14861-14870
-
-
Yuan, T.1
Wang, Y.2
Zhao, Z.J.3
Gu, H.4
-
21
-
-
4444247676
-
Control of vesicle fusion by a tyrosine phosphatase
-
10.1038/ncb1164, 15322554
-
Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol 2004, 6:831-839. 10.1038/ncb1164, 15322554.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 831-839
-
-
Huynh, H.1
Bottini, N.2
Williams, S.3
Cherepanov, V.4
Musumeci, L.5
Saito, K.6
Bruckner, S.7
Vachon, E.8
Wang, X.9
Kruger, J.10
Chow, C.W.11
Pellecchia, M.12
Monosov, E.13
Greer, P.A.14
Trimble, W.15
Downey, G.P.16
Mustelin, T.17
-
22
-
-
28544437137
-
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function
-
10.1084/jem.20051108, 2213338, 16330817
-
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med 2005, 202:1587-1597. 10.1084/jem.20051108, 2213338, 16330817.
-
(2005)
J Exp Med
, vol.202
, pp. 1587-1597
-
-
Wang, Y.1
Vachon, E.2
Zhang, J.3
Cherepanov, V.4
Kruger, J.5
Li, J.6
Saito, K.7
Shannon, P.8
Bottini, N.9
Huynh, H.10
Ni, H.11
Yang, H.12
McKerlie, C.13
Quaggin, S.14
Zhao, Z.J.15
Marsden, P.A.16
Mustelin, T.17
Siminovitch, K.A.18
Downey, G.P.19
-
23
-
-
0344737696
-
PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells
-
10.1182/blood-2003-04-1308, 12920026
-
Xu MJ, Sui X, Zhao R, Dai C, Krantz SB, Zhao ZJ. PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells. Blood 2003, 102:4354-4360. 10.1182/blood-2003-04-1308, 12920026.
-
(2003)
Blood
, vol.102
, pp. 4354-4360
-
-
Xu, M.J.1
Sui, X.2
Zhao, R.3
Dai, C.4
Krantz, S.B.5
Zhao, Z.J.6
-
24
-
-
80054114850
-
Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer
-
10.1186/bcr2921, 22018398
-
Furth PA, Nakles RE, Millman S, Diaz-Cruz ES, Cabrera MC. Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer. Breast Cancer Res 2011, 13:220. 10.1186/bcr2921, 22018398.
-
(2011)
Breast Cancer Res
, vol.13
, pp. 220
-
-
Furth, P.A.1
Nakles, R.E.2
Millman, S.3
Diaz-Cruz, E.S.4
Cabrera, M.C.5
-
25
-
-
0037124037
-
Interdomain interaction of Stat3 regulates its Src homology 2 domain-mediated receptor binding activity
-
10.1074/jbc.M105525200, 11872739
-
Zhang T, Seow KT, Ong CT, Cao X. Interdomain interaction of Stat3 regulates its Src homology 2 domain-mediated receptor binding activity. J Biol Chem 2002, 277:17556-17563. 10.1074/jbc.M105525200, 11872739.
-
(2002)
J Biol Chem
, vol.277
, pp. 17556-17563
-
-
Zhang, T.1
Seow, K.T.2
Ong, C.T.3
Cao, X.4
-
26
-
-
44649159499
-
Varp interacts with Rab38 and functions as its potential effector
-
10.1016/j.bbrc.2008.05.017, 18477474
-
Wang F, Zhang H, Zhang X, Wang Y, Ren F, Zhai Y, Chang Z. Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun 2008, 372:162-167. 10.1016/j.bbrc.2008.05.017, 18477474.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 162-167
-
-
Wang, F.1
Zhang, H.2
Zhang, X.3
Wang, Y.4
Ren, F.5
Zhai, Y.6
Chang, Z.7
-
27
-
-
0035986588
-
Purification and characterization of protein tyrosine phosphatase PTP-MEG2
-
10.1002/jcb.10195, 12112018
-
Qi Y, Zhao R, Cao H, Sui X, Krantz SB, Zhao ZJ. Purification and characterization of protein tyrosine phosphatase PTP-MEG2. J Cell Biochem 2002, 86:79-89. 10.1002/jcb.10195, 12112018.
-
(2002)
J Cell Biochem
, vol.86
, pp. 79-89
-
-
Qi, Y.1
Zhao, R.2
Cao, H.3
Sui, X.4
Krantz, S.B.5
Zhao, Z.J.6
-
28
-
-
42749093205
-
Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma
-
10.1016/j.canlet.2008.01.025, 18334282
-
Zhou L, He XD, Cui QC, Zhou WX, Qu Q, Zhou RL, Rui JA, Yu JC. Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma. Cancer Lett 2008, 264:209-217. 10.1016/j.canlet.2008.01.025, 18334282.
-
(2008)
Cancer Lett
, vol.264
, pp. 209-217
-
-
Zhou, L.1
He, X.D.2
Cui, Q.C.3
Zhou, W.X.4
Qu, Q.5
Zhou, R.L.6
Rui, J.A.7
Yu, J.C.8
-
29
-
-
44349087591
-
STAT 3 as a target for cancer drug discovery
-
10.2174/092986708783955464, 18473793
-
Costantino L, Barlocco D. STAT 3 as a target for cancer drug discovery. Curr Med Chem 2008, 15:834-843. 10.2174/092986708783955464, 18473793.
-
(2008)
Curr Med Chem
, vol.15
, pp. 834-843
-
-
Costantino, L.1
Barlocco, D.2
-
30
-
-
78650601353
-
Inside the human cancer tyrosine phosphatome
-
Julien SG, Dube N, Hardy S, Tremblay ML. Inside the human cancer tyrosine phosphatome. Nat Rev Cancer 2010, 11:35-49.
-
(2010)
Nat Rev Cancer
, vol.11
, pp. 35-49
-
-
Julien, S.G.1
Dube, N.2
Hardy, S.3
Tremblay, M.L.4
-
31
-
-
79952292499
-
Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase
-
10.1016/j.cell.2011.02.003, 21376233
-
Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase. Cell 2011, 144:703-718. 10.1016/j.cell.2011.02.003, 21376233.
-
(2011)
Cell
, vol.144
, pp. 703-718
-
-
Sun, T.1
Aceto, N.2
Meerbrey, K.L.3
Kessler, J.D.4
Zhou, C.5
Migliaccio, I.6
Nguyen, D.X.7
Pavlova, N.N.8
Botero, M.9
Huang, J.10
Bernardi, R.J.11
Schmitt, E.12
Hu, G.13
Li, M.Z.14
Dephoure, N.15
Gygi, S.P.16
Rao, M.17
Creighton, C.J.18
Hilsenbeck, S.G.19
Shaw, C.A.20
Muzny, D.21
Gibbs, R.A.22
Wheeler, D.A.23
Osborne, C.K.24
Schiff, R.25
Bentires-Alj, M.26
Elledge, S.J.27
Westbrook, T.F.28
more..
-
32
-
-
50249142447
-
Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls
-
10.1080/08880010802237054, 18728972
-
Fridberg M, Kjellstrom S, Anagnostaki L, Skogvall I, Mustelin T, Wiebe T, Persson JL, Dictor M, Wingren AG. Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. Pediatr Hematol Oncol 2008, 25:528-540. 10.1080/08880010802237054, 18728972.
-
(2008)
Pediatr Hematol Oncol
, vol.25
, pp. 528-540
-
-
Fridberg, M.1
Kjellstrom, S.2
Anagnostaki, L.3
Skogvall, I.4
Mustelin, T.5
Wiebe, T.6
Persson, J.L.7
Dictor, M.8
Wingren, A.G.9
-
33
-
-
77953753795
-
PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase
-
10.1158/0008-5472.CAN-09-4368, 3132424, 20501847
-
Glondu-Lassis M, Dromard M, Lacroix-Triki M, Nirde P, Puech C, Knani D, Chalbos D, Freiss G. PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. Cancer Res 2010, 70:5116-5126. 10.1158/0008-5472.CAN-09-4368, 3132424, 20501847.
-
(2010)
Cancer Res
, vol.70
, pp. 5116-5126
-
-
Glondu-Lassis, M.1
Dromard, M.2
Lacroix-Triki, M.3
Nirde, P.4
Puech, C.5
Knani, D.6
Chalbos, D.7
Freiss, G.8
-
34
-
-
34547113096
-
The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation
-
10.1158/0008-5472.CAN-07-0513, 17638892
-
Dromard M, Bompard G, Glondu-Lassis M, Puech C, Chalbos D, Freiss G. The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation. Cancer Res 2007, 67:6806-6813. 10.1158/0008-5472.CAN-07-0513, 17638892.
-
(2007)
Cancer Res
, vol.67
, pp. 6806-6813
-
-
Dromard, M.1
Bompard, G.2
Glondu-Lassis, M.3
Puech, C.4
Chalbos, D.5
Freiss, G.6
|