Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A-benzodiazepine receptor: A novel neurological activity of seaweed polyphenols

Food Chemistry

Volumn 132, Issue 3, 2012, Pages 1133-1142

  Cho, Suengmok ^a,b   Yang, Hyejin ^a   Jeon, You Jin ^c   Lee, C Justin ^d   Jin, Young Ho ^e   Baek, Nam In ^f   Kim, Dongsoo ^a   Kang, Sung Myung ^c   Yoon, Minseok ^a   Yong, Heim ^a   Shimizu, Makoto ^b   Han, Daeseok ^a  

^a Korea Food Research Institute   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

^c Jeju National University   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Kyung Hee University Hospital   (South Korea)

^f Kyung Hee University   (South Korea)

Author keywords

Ecklonia cava Kjellman; Edible seaweeds; GABA type A benzodiazepine receptor; Hypnotic activity; Phlorotannin

Indexed keywords

ALLOSTERIC MODULATION; BINDING ACTIVITIES; BINDING AFFINITIES; BROWN SEAWEED; ECKLONIA CAVA; EDIBLE SEAWEED; ETHANOL EXTRACT; ETHYL ACETATES; GABA TYPE A-BENZODIAZEPINE RECEPTOR; GAMMA-AMINOBUTYRIC ACIDS; METHANOL EXTRACT; MOLECULAR TARGETS; PHLOROTANNIN; POLYPHENOLS; PRIMARY OBJECTIVE; RECEPTOR ANTAGONISTS; SOLVENT FRACTION; TOTAL PHENOLS;

AMINO ACIDS; BINDING ENERGY; ETHANOL; METHANOL; PHENOLS; SLEEP RESEARCH;

SEAWEED;

4 AMINOBUTYRIC ACID A RECEPTOR; ACETIC ACID ETHYL ESTER; ALGAL EXTRACT; BENZODIAZEPINE RECEPTOR; DIECKOL; ECKLONIA CAVA EXTRACT; ECKOL; ECKSTOLONOL; FLUMAZENIL; HYPNOTIC SEDATIVE AGENT; PENTOBARBITAL; PHLOROGLUCINOL; POLYPHENOL DERIVATIVE; TANNIN DERIVATIVE; TRIPHLORETHOL A; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMICAL COMPOSITION; BRAIN CORTEX; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ECKLONIA CAVA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPNOSIS; MOUSE; NEUROMODULATION; NONHUMAN; RECEPTOR BINDING; SEAWEED; SEPARATION TECHNIQUE; SLEEP; SLEEP QUALITY; STRUCTURE ACTIVITY RELATION;

ECKLONIA CAVA; MUS;

EID: 84862798191     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.08.040     Document Type: Article

References (48)

1. A.N. Bateson Further potential of the GABA receptor in the treatment of insomnia Sleep Medicine 7 1 2006 3 9
2. J.W. Blunt, B.R. Copp, W.P. Hu, M.H.G. Munro, P.T. Northcote, and M.R. Prinsep Marine natural products Natural Product Reports 24 1 2007 31 86
3. N.L. Borja, and K.L. Daniel Ramelteon for the treatment of insomnia Clinical Therapeutics 28 10 2006 1540 1555
4. J. Bouayed, H. Rammal, A. Dicko, C. Younos, and R. Soulimani Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects Journal of the Neurological Sciences 262 1-2 2007 77 84
5. M. Cho, H.S. Lee, I.J. Kang, M.H. Won, and S. You Antioxidant properties of extract and fractions from Enteromorpha prolifera, a type of green seaweed Food Chemistry 127 3 2011 999 1006
6. 2C receptors of traditional medicinal plants used in Asia for insomnia Journal of Ethnopharmacology 132 1 2010 225 232
7. L.A.A. de-Jong, D.R.A. Uges, J.P. Franke, and R. Bischoff Receptor-ligand binding assays: Technologies and applications Journal of Chromatography B 829 1-2 2005 1 25
8. K. Doghramji The epidemiology and diagnosis of insomnia The American Journal of Managed Care 12 8 2006 214 220
9. X.S. Fang, J.F. Hao, H.Y. Zhou, L.X. Zhu, J.H. Wang, and F.Q. Song Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suanzaoren) and Radix et Rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations Phytomedicine 17 1 2010 75 80
10. N. Felix, M. Jennifer, A.L. Victoria, S. Derek, A.R. Heather, and J.M. Gordon Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae Food Chemistry 126 3 2011 1006 1012
11. J.H. Fitton Brown marine algae: A survey of therapeutic potentials Alternative Complementary Therapies 9 1 2003 29 33
12. C. Gottesmann GABA mechanisms and sleep Neuroscience 111 2 2002 231 239
13. S.J. Heo, K.W. Lee, C.B. Song, and Y.J. Jeon Antioxidant activity of enzymatic extracts from brown seaweeds Algae 18 1 2003 71 81
14. K.M. Hui, M.S.Y. Huen, H.Y. Wang, H. Zheng, E. Sigel, and R. Baur Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi Biochemical Pharmacology 64 9 2002 1415 1424
15. L. Imeri, and M.R. Opp How (and why) the immune system makes us sleep Nature Review Neuroscience 10 3 2009 199 210
16. A.K. Jäger, and L. Saaby Flavonoids and the CNS Molecules 16 2 2011 1471 1485
17. A receptor channel pharmacology Current Pharmaceutical Design 11 15 2005 1867 1885
18. D. Kavvadias, P. Sand, K.A. Youdim, M.Z. Qaiser, C. Rice-Evans, and R. Baur The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects British Journal of Pharmacology 142 5 2004 811 820
19. A.R. Kim, T.S. Shin, M.S. Lee, J.Y. Park, K.E. Park, and N.Y. Yoon Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties Journal of Agricultural and Food Chemistry 57 9 2009 3483 3489
20. J.M. Krueger, D.M. Rector, S. Roy, H.P. Van Dongen, G. Belenky, and J. Panksepp Sleep as a fundamental property of neuronal assemblies Nature Review Neuroscience 9 12 2008 910 919
21. S.H. Lee, J.S. Han, S.J. Heo, J.Y. Hwang, and Y.J. Jeon Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells Toxicology in Vitro 24 2 2010 375 381
22. Y. Li, Z.J. Qian, B. Ryu, S.H. Lee, M.M. Kim, and S.K. Kim Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava Bioorganic and Medicinal Chemistry 17 5 2009 1963 1973
23. McHugh, D. J. (2003). A guide to the seaweed industry. FAO Fisheries Technical Paper, No. 441, Rome.
24. C.D. Meletis, and N. Zabriskie Natural approaches for optimal sleep Alternative and Complementary Therapies 14 4 2008 181 188
25. S. Moon, and J. Kim Iodine content of human milk and dietary iodine intake of Korean lactating mothers International Journal of Food Science and Nutrition 50 3 1999 165 171
26. C. Myung, H. Shin, H. Bao, S. Yeo, B. Lee, and J. Kang Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: Possible involvement of the inhibition of acetylcholinesterase Archives of Pharmacal Research 28 6 2005 691 698
27. K. Nagayama, Y. Iwamura, T. Shibata, I. Hirayama, and T. Nakamura Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome The Journal of Antimicrobial Chemotherapy 50 6 2002 889 893
28. A.M. O'Sullivan, Y.C. O'Callaghan, M.N. O'Grady, B. Queguineur, D. Hanniffy, and D.J. Troy In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland Food Chemistry 126 3 2011 1064 1070
29. R. Pangestuti, and S.K. Kim Neuroprotective effects of marine algae Marine drugs 9 5 2011 803 818
30. N.J. Pearson, L.L. Johnson, and R.L. Nahin Insomnia, trouble sleeping, and complementary and alternative medicine: Analysis of the 2002 national health interview survey data Archives of Internal Medicine 166 16 2006 1775 1782
31. A-benzodiazepine receptor assay Journal of Ethnopharmacology 93 2-3 2004 177 182
32. A. Rodriguez-Bernaldo de Quiros, S. Frecha-Ferreiro, A.M. Vidal-Perez, and J. Lopez-Hernandez Antioxidant compounds in edible brown seaweeds European Food Research and Technology 231 3 2010 495 498
33. A-benzodiazepine receptor activity Journal of Ethnopharmacology 99 1 2005 145 146
34. T. Shibata, K. Fujimoto, K. Nagayama, K. Yamaguchi, and T. Nakayama Inhibitory activity of brown algal phlorotannins against hyaluronidase International Journal of Food Science and Technology 37 6 2002 703 709
35. T. Shibata, S. Kawaguchi, Y. Hama, M. Inagaki, K. Yamaguchi, and T. Nakamura Local and chemical distribution of phlorotannins in brown algae Journal of Applied Phycology 16 4 2004 291 296
36. A receptors Trends in Pharmacological Sciences 18 11 1997 425 429
37. K. Slinkard, and V.L. Singleton Total phenol analysis: Automation and comparison with manual Methods American Journal of Enology and Viticulture 28 1 1977 49 55
38. A.J. Smit Medicinal and pharmaceutical uses of seaweed natural products: A review Journal of Applied Phycology 16 4 2004 245 262
39. N. Suganthy, S. Karutha Pandian, and P. Devi Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar marine biosphere reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata Neuroscience Letters 468 3 2010 216 219
40. Y. Sugiura, K. Matsuda, Y. Yamada, M. Nishikawa, K. Shioya, and H. Katsuzaki Isolation of a new anti-allergic phlorotannin, phlorofucofuroeckol-B, from an edible brown alga, Eisenia arborea Bioscience, Biotechnology and Biochemistry 70 11 2006 2807 2811
41. R. Thomas, and D. Christopher Evolution of insomnia: Current status and future direction Sleep Medicine 5 1 2004 23 30
42. M. Vignes, T. Maurice, F. Lanté, M. Nedjar, K. Thethi, and J. Guiramand Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG) Brain Research 1110 1 2006 102 115
43. H. Viola, C. Wasowski, M. Levi de Stein, C. Wolfman, R. Silveira, and F. Dajas Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects Planta Medica 61 3 1995 213 216
44. T. Wang, R. Jonsdottir, and G. Olafsdottir Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds Food Chemistry 116 1 2009 240 248
45. A receptors, from Valeriana wallichii Planta Medica 68 10 2002 934 936
46. N.Y. Yoon, H.Y. Chung, H.R. Kim, and J.S. Choi Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera Fisheries Science 74 1 2008 200 207
47. M. Zhu, N.G. Bowery, P.M. Greengrass, and J.D. Phillipson Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants Journal of Ethnopharmacology 54 2-3 1996 153 164
48. Y. Zou, Z.J. Qian, Y. Li, M.M. Kim, S.H. Lee, and S.K. Kim Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical mediated oxidative systems Journal of Agricultural and Food Chemistry 56 16 2008 7001 7009