메뉴 건너뛰기




Volumn 196, Issue 1, 2012, Pages 56-67

Overexpression of GDF5 through an adenovirus vector stimulates osteogenesis of human mesenchymal stem cells in vitro and in vivo

Author keywords

GDF5; Gene therapy; Mesenchymal stem cell; Osteogenesis

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; GROWTH DIFFERENTIATION FACTOR 5; OSTEOCALCIN;

EID: 84862794255     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000330791     Document Type: Article
Times cited : (12)

References (36)
  • 1
    • 7744227932 scopus 로고    scopus 로고
    • Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes
    • DOI 10.1016/j.bbrc.2004.10.055, PII S0006291X04023186
    • Bai X, Xiao Z, Pan Y, Hu J, Pohl J, Wen J, Li L (2004) Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes. Biochem Biophys Res Commun 325: 453-460. (Pubitemid 39461985)
    • (2004) Biochemical and Biophysical Research Communications , vol.325 , Issue.2 , pp. 453-460
    • Bai, X.1    Xiao, Z.2    Pan, Y.3    Hu, J.4    Pohl, J.5    Wen, J.6    Li, L.7
  • 2
    • 1342327559 scopus 로고    scopus 로고
    • Regional gene therapy to enhance bone repair
    • DOI 10.1038/sj.gt.3302195, Gene Therapy for Orthopaedics
    • Baltzer AW, Lieberman JR (2004) Regional gene therapy to enhance bone repair. Gene Ther 11: 344-350. (Pubitemid 38263084)
    • (2004) Gene Therapy , vol.11 , Issue.4 , pp. 344-350
    • Baltzer, A.W.A.1    Lieberman, J.R.2
  • 3
    • 0036073259 scopus 로고    scopus 로고
    • Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis
    • DOI 10.1053/joca.2002.0522
    • Bobacz K, Gruber R, Soleiman A, Graninger WB, Luyten FP, Erlacher L (2002) Cartilagederived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage 10: 394-401. (Pubitemid 34662374)
    • (2002) Osteoarthritis and Cartilage , vol.10 , Issue.5 , pp. 394-401
    • Bobacz, K.1    Gruber, R.2    Soleiman, A.3    Graninger, W.B.4    Luyten, F.P.5    Erlacher, L.6
  • 5
    • 0029314291 scopus 로고
    • Current concepts review: Enhancement of fracture-healing
    • Einhorn TA (1995) Current concepts review: enhancement of fracture-healing. Bone Joint Surg 77A: 940-956.
    • (1995) Bone. Joint. Surg. , vol.77 A , pp. 940-956
    • Einhorn, T.A.1
  • 6
    • 46249089768 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells
    • DOI 10.1080/08977190802105917, PII 793242491
    • Feng G, Wan Y, Balian G, Laurencin CT, Li X (2008) Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. Growth Factors 26: 132-142. (Pubitemid 351911395)
    • (2008) Growth Factors , vol.26 , Issue.3 , pp. 132-142
    • Feng, G.1    Wan, Y.2    Balian, G.3    Laurencin, C.T.4    Li, X.5
  • 7
    • 0032841147 scopus 로고    scopus 로고
    • Does adult fracture repair recapitulate embryonic skeletal formation?
    • DOI 10.1016/S0925-4773(99)00142-2, PII S0925477399001422
    • Ferguson C, Alpern E, Miclau T, Helms JA (1999) Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 87: 57-66. (Pubitemid 29428086)
    • (1999) Mechanisms of Development , vol.87 , Issue.1-2 , pp. 57-66
    • Ferguson, C.1    Alpern, E.2    Miclau, T.3    Helms, J.A.4
  • 8
    • 0036514908 scopus 로고    scopus 로고
    • Bone-grafting and bonegraft substitutes
    • Finkemeier CG (2002) Bone-grafting and bonegraft substitutes. J Bone Joint Surg Am 84-A: 454-464.
    • (2002) J. Bone Joint Surg. Am. , vol.84 A , pp. 454-464
    • Finkemeier, C.G.1
  • 11
    • 0031792031 scopus 로고    scopus 로고
    • Angiogenesis in fracture repair
    • ed 1, New Jersey, Wiley suppl
    • Glowacki J (1998) Angiogenesis in fracture repair. Clin Orthop Relat Res (suppl): S82-S89.
    • (1998) Clin. Orthop. Relat. Res.
    • Glowacki, J.1
  • 12
    • 19544377964 scopus 로고    scopus 로고
    • Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation
    • DOI 10.1016/j.yexcr.2005.03.018, PII S0014482705001394, Molecular Control of Stem Cell Differentiation
    • Gregory CA, Prockop DJ, Spees JL (2005) Nonhematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res 306: 330-335. (Pubitemid 40732757)
    • (2005) Experimental Cell Research , vol.306 , Issue.2 , pp. 330-335
    • Gregory, C.A.1    Prockop, D.J.2    Spees, J.L.3
  • 13
    • 4644358680 scopus 로고    scopus 로고
    • Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis
    • Hatakeyama Y, Tuan RS, Shum L (2004) Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J Cell Biochem 91: 1204-1217.
    • (2004) J. Cell Biochem , vol.91 , pp. 1204-1217
    • Hatakeyama, Y.1    Tuan, R.S.2    Shum, L.3
  • 14
  • 15
    • 33749545758 scopus 로고    scopus 로고
    • Virus-based gene therapy strategies for bone regeneration
    • DOI 10.1016/j.biomaterials.2006.07.032, PII S0142961206006557
    • Phillips JE, Gersbach CA, García AJ (2007) Virus- based gene therapy strategies for bone regeneration. Biomaterials 28: 211-229. (Pubitemid 44537380)
    • (2007) Biomaterials , vol.28 , Issue.2 , pp. 211-229
    • Phillips, J.E.1    Gersbach, C.A.2    Garcia, A.J.3
  • 16
    • 77649274205 scopus 로고    scopus 로고
    • The effect of two point mutations in GDF-5 on ectopic bone formation in a beta-tricalciumphosphate scaffold
    • Kasten P, Beyen I, Bormann D, LuginbÜhl R, Plöger F, Richter W (2010) The effect of two point mutations in GDF-5 on ectopic bone formation in a beta-tricalciumphosphate scaffold. Biomaterials 31: 3878-3884.
    • (2010) Biomaterials , vol.31 , pp. 3878-3884
    • Kasten, P.1    Beyen, I.2    Bormann, D.3    Luginbühl, R.4    Plöger, F.5    Richter, W.6
  • 17
    • 0042834336 scopus 로고    scopus 로고
    • BMP signaling components are expressed in human fracture callus
    • DOI 10.1016/S8756-3282(03)00191-1
    • Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (2003) BMP signalling components are expressed in human fracture callus. Bone 33: 362-371. (Pubitemid 37103253)
    • (2003) Bone , vol.33 , Issue.3 , pp. 362-371
    • Kloen, P.1    Di Paola, M.2    Borens, O.3    Richmond, J.4    Perino, G.5    Helfet, D.L.6    Goumans, M.J.7
  • 18
    • 65449189690 scopus 로고    scopus 로고
    • Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type i receptor specificity
    • Kotzsch A, Nickel J, Seher A, Sebald W, MÜller TD (2009) Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. EMBO J 287: 937-947.
    • (2009) EMBO J. , vol.287 , pp. 937-947
    • Kotzsch, A.1    Nickel, J.2    Seher, A.3    Sebald, W.4    Müller, T.D.5
  • 19
    • 67649531539 scopus 로고    scopus 로고
    • Global burden of trauma: Need for effective therapies
    • Mathew G, Hanson BP (2009) Global burden of trauma: need for effective therapies. Indian J Orthop 43: 111-116.
    • (2009) Indian J. Orthop. , vol.43 , pp. 111-116
    • Mathew, G.1    Hanson, B.P.2
  • 20
    • 0035032914 scopus 로고    scopus 로고
    • Divergence and convergence of TGF-beta/BMP signaling
    • Miyazono K, Kusanagi K, Inoue H (2001) Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 187: 265-276.
    • (2001) J. Cell Physiol , vol.187 , pp. 265-276
    • Miyazono, K.1    Kusanagi, K.2    Inoue, H.3
  • 21
    • 20344385511 scopus 로고    scopus 로고
    • A single residue of GDF-5 defines binding specificity to BMP receptor IB
    • DOI 10.1016/j.jmb.2005.04.015, PII S0022283605004146
    • Nickel J, Kotzsch A, Sebald W, Mueller TD (2005) A single residue of GDF-5 defines binding specificity to BMP receptor IB. J Mol Biol 349: 933-947. (Pubitemid 40779617)
    • (2005) Journal of Molecular Biology , vol.349 , Issue.5 , pp. 933-947
    • Nickel, J.1    Kotzsch, A.2    Sebald, W.3    Mueller, T.D.4
  • 22
    • 33645118695 scopus 로고    scopus 로고
    • Adenovirusmediated gene transfer of growth and differentiation factor-5 into tenocytes and the healing rat achilles tendon
    • Rickert M, Wang H, Wieloch P, Lorenz H, Steck E, Sabo D, Richter W (2005) Adenovirusmediated gene transfer of growth and differentiation factor-5 into tenocytes and the healing rat achilles tendon. Connect Tissue Res 46: 175-183.
    • (2005) Connect Tissue. Res. , vol.46 , pp. 175-183
    • Rickert, M.1    Wang, H.2    Wieloch, P.3    Lorenz, H.4    Steck, E.5    Sabo, D.6    Richter, W.7
  • 23
    • 62849085513 scopus 로고    scopus 로고
    • Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: A review
    • Romano CL, Romano D, Logoluso N (2009) Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: A review. Ultrasound Med Biol 35: 529-536.
    • (2009) Ultrasound Med. Biol. , vol.35 , pp. 529-536
    • Romano, C.L.1    Romano, D.2    Logoluso, N.3
  • 24
    • 14844292085 scopus 로고    scopus 로고
    • Crystal structure of recombinant human growth and differentiation factor 5: Evidence for interaction of the type i and type II receptor-binding sites
    • DOI 10.1016/j.bbrc.2005.02.078
    • Schreuder H, Liesum A, Pohl J, Kruse M, Koyama M (2005) Crystal structure of recombinant human growth and differentiation factor 5: evidence for interaction of the type I and type II receptor-binding sites. Biochem Biophys Res Commun 329: 1076-1086. (Pubitemid 40341385)
    • (2005) Biochemical and Biophysical Research Communications , vol.329 , Issue.3 , pp. 1076-1086
    • Schreuder, H.1    Liesum, A.2    Pohl, J.3    Kruse, M.4    Koyama, M.5
  • 25
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality
    • Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ (2002) Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 20: 530-541. (Pubitemid 35463066)
    • (2002) Stem Cells , vol.20 , Issue.6 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3    Pochampally, R.4    Cui, J.-G.5    Prockop, D.J.6
  • 26
    • 37349019717 scopus 로고    scopus 로고
    • Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5
    • DOI 10.1080/03008200701692743, PII 788423368
    • Sena K, Sumner DR, Virdi AS (2007) Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5. Connect Tissue Res 48: 324-331. (Pubitemid 350285397)
    • (2007) Connective Tissue Research , vol.48 , Issue.6 , pp. 324-331
    • Sena, K.1    Sumner, D.R.2    Virdi, A.S.3
  • 27
    • 33750502474 scopus 로고    scopus 로고
    • Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix
    • DOI 10.1016/j.spinee.2006.03.006, PII S1529943006001720
    • Shen FH, Zeng Q, Lv Q, Choi L, Balian G, Li X, Laurencin CT (2006) Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine 6: 615-623. (Pubitemid 44660876)
    • (2006) Spine Journal , vol.6 , Issue.6 , pp. 615-623
    • Shen, F.H.1    Zeng, Q.2    Lv, Q.3    Choi, L.4    Balian, G.5    Li, X.6    Laurencin, C.T.7
  • 30
    • 33947305450 scopus 로고    scopus 로고
    • Molecular aspects of fracture healing: Which are important molecules
    • Tsiridis E, Upadhyay N, Giannoudis P (2007) Molecular aspects of fracture healing: which are important molecules? Injury 38: 11-25.
    • (2007) Injury , vol.38 , pp. 11-25
    • Tsiridis, E.1    Upadhyay, N.2    Giannoudis, P.3
  • 31
    • 0036233716 scopus 로고    scopus 로고
    • Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis
    • Tsumaki N, Nakase T, Miyaji T, Kakiuchi M, Kimura T, Ochi T, Yoshikawa H (2002) Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis. J Bone Miner Res 17: 898-906. (Pubitemid 34441907)
    • (2002) Journal of Bone and Mineral Research , vol.17 , Issue.5 , pp. 898-906
    • Tsumaki, N.1    Nakase, T.2    Miyaji, T.3    Kakiuchi, M.4    Kimura, T.5    Ochi, T.6    Yoshikawa, H.7
  • 32
    • 0012248154 scopus 로고    scopus 로고
    • Delivery systems for BMPs: Factors contributing to protein retention at an application site
    • Uludag H, Gao T, Porter TJ, Friess W, Wozney JM (2001) Delivery systems for BMPs: factors contributing to protein retention at an application site. J Bone Joint Surg Am 83-A (suppl 1): S128-S135.
    • (2001) J. Bone Joint Surg. Am. , vol.83 A , Issue.SUPPL. 1
    • Uludag, H.1    Gao, T.2    Porter, T.J.3    Friess, W.4    Wozney, J.M.5
  • 33
    • 1542284506 scopus 로고    scopus 로고
    • Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells
    • DOI 10.1007/s00109-003-0507-y
    • Wang H, Kroeber M, Hanke M, Ries R, Schmid C, Poller W, Richter W (2004) Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J Mol Med 82: 126-134. (Pubitemid 38299711)
    • (2004) Journal of Molecular Medicine , vol.82 , Issue.2 , pp. 126-134
    • Wang, H.1    Kroeber, M.2    Hanke, M.3    Ries, R.4    Schmid, C.5    Poller, W.6    Richter, W.7
  • 34
    • 33644754589 scopus 로고    scopus 로고
    • Recombinant human growth/differentiation factor-5 (rhGDF-5) induced bone formation in murine calvariae
    • DOI 10.1111/j.1600-0765.2005.00847.x
    • Yoshimoto T, Yamamoto M, Kadomatsu H, Sakoda K, Yonamine Y, Izumi Y (2006) Recombinant human growth/differentiation factor- 5 (rhGDF-5) induced bone formation in murine calvariae. J Periodontal Res 41: 140-147. (Pubitemid 43341287)
    • (2006) Journal of Periodontal Research , vol.41 , Issue.2 , pp. 140-147
    • Yoshimoto, T.1    Yamamoto, M.2    Kadomatsu, H.3    Sakoda, K.4    Yonamine, Y.5    Izumi, Y.6
  • 35
    • 33846168436 scopus 로고    scopus 로고
    • Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro
    • DOI 10.1016/j.bone.2006.09.022, PII S8756328206007368
    • Zeng Q, Li X, Beck G, Balian G, Shen FH (2007) Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro. Bone 40: 374-381. (Pubitemid 46075207)
    • (2007) Bone , vol.40 , Issue.2 , pp. 374-381
    • Zeng, Q.1    Li, X.2    Beck, G.3    Balian, G.4    Shen, F.H.5
  • 36
    • 33751331471 scopus 로고    scopus 로고
    • Recombinant growth/differentiation factor-5 stimulates osteogenic differentiation of fat-derived stromal cells in vitro
    • DOI 10.1080/03008200600980769, PII P1P5538235743K61
    • Zeng Q, Li X, Choi L, Beck G, Balian G, Shen FH (2006) Recombinant growth/differentiation factor-5 stimulates osteogenic differentiation of fat-derived stromal cells in vitro. Connect Tissue Res 47: 264-270. (Pubitemid 44803794)
    • (2006) Connective Tissue Research , vol.47 , Issue.5 , pp. 264-270
    • Zeng, Q.1    Li, X.2    Choi, L.3    Beck, G.4    Balian, G.5    Shen, F.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.