PPARγagonist pioglitazone improves scopolamine-induced memory impairment in mice

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 4, 2012, Pages 589-596

  Xiang, Guo Qing ^a   Tang, Su Su ^a   Jiang, Li Ying ^a   Hong, Hao ^a   Li, Qing ^a   Wang, Chao ^a   Wang, Xiao Yun ^a   Zhang, Ting Ting ^a   Yin, Lei ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

central cholinergic system; dementia; learning and memory; pioglitazone

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINE ACETYLTRANSFERASE; DONEPEZIL; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CHOLINERGIC ACTIVITY; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; LATENT PERIOD; MALE; MAZE TEST; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE; SPATIAL MEMORY;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; AVOIDANCE LEARNING; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HYPOGLYCEMIC AGENTS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED ICR; MUSCARINIC ANTAGONISTS; NEUROPROTECTIVE AGENTS; PPAR GAMMA; SCOPOLAMINE HYDROBROMIDE; THIAZOLIDINEDIONES;

EID: 84862791475     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01432.x     Document Type: Article

References (31)

1. Ballard C, et al,. Alzheimer's disease. Lancet 2011; 377: 1019-1031.
2. Bartus RT, et al,. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408-414.
3. Van Beek AH, Claassen JA,. The cerebrovascular role of the cholinergic neural system in Alzheimer's disease. Behav Brain Res 2011; 1221: 537-542.
4. Mandrekar-Colucci S, Landreth GE,. Nuclear receptors as therapeutic targets for Alzheimer's disease. Expert Opin Ther Targets 2011; 15: 1085-1097.
5. Derosa G,. Efficacy and tolerability of pioglitazone in patients with type 2 diabetes mellitus: comparison with other oral antihyperglycaemic agents. Drugs 2010; 70: 1945-1961.
6. Lehmann JM, et al,. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995; 270: 12953-12956.
7. Hemauer SJ, et al,. Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. Am J Obstet Gynecol 2010; 202: 383 e1-383 e7.
8. d'Abramo C, et al,. Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. Biochem J 2006; 391: 693-698. (Pubitemid 41634796)
9. Heneka MT, et al,. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta 1-42 levels in APPV717I transgenic mice. Brain 2005; 128: 1442-1453. (Pubitemid 40826196)
10. Hanyu H, et al,. Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J Am Geriatr Soc 2009; 57: 177-179.
11. Sato T, et al,. Efficacy of PPAR γagonist pioglitazone in mild Alzheimer disease. Neurobiol Aging 2011; 32: 1626-1633.
12. Geldmacher DS, et al,. A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Arch Neurol 2011; 68: 45-50.
13. Sakurai T,. Targets of the peroxisome proliferator-activated receptor γagonist trials for the prevention of Alzheimer disease. Arch Neurol 2011; 68: 542.
14. Sanchez-Mejia RO, et al,. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci 2008; 11: 1311-1318.
15. Cheng DH, Tang XC,. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998; 60: 377-386. (Pubitemid 28282678)
16. Ellman GL, et al,. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.
17. Takahiko K,. Enzymatic determination of choline acetyltransferase by coenzyme A cycling and its application to analysis of single mammalian neurons. J Neurochem 1984; 42: 903-910.
18. Liem-Moolenaar M, et al,. The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects. J Psychopharmacol 2010; 24: 1681-1687.
19. Kopelman MD, Corn TH,. Cholinergic 'blockade' as a model for cholinergic depletion. A comparison of the memory deficits with those of Alzheimer-type dementia and the alcoholic Korsakoff syndrome. Brain Res 1988; 111: 1079-1110.
20. Spignoli G, et al,. Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat. Pharmacol Res Commun 1987; 19: 901-912. (Pubitemid 18038394)
21. van der Staay FJ, Bouger PC,. Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats. Behav Brain Res 2005; 156: 1-10. (Pubitemid 39330431)
22. Ghadami MR, et al,. The effect of Crocin on scopolamine induced spatial learning and memory deficits in rats. Physiol Pharmacol 2009; 12: 287-295.
23. Kwon SH, et al,. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol 2009; 619: 44-44.
24. Lee B, et al,. Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus. J Pharm Pharmacol 2010; 62: 263-271.
25. Oh JH, et al,. Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. Neurosci Lett 2009; 461: 41-44.
26. Liu HL, et al,. Protective effects of Kangshou ling on scopolamine-induced amnesia in rats and its molecular mechanisms. J Chin Hosp Pharm 2008; 28: 183-185.
27. Maeshiba Y, et al,. Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys. Arzneimittelforschung 1997; 47: 29-35. (Pubitemid 27083325)
28. Mohapel P, et al,. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging 2005; 36: 939-946. (Pubitemid 40249497)
29. Schliebs R, Arendt T,. The cholinergic system in aging and neuronal degeneration. Behav Brain Res 2011; 221: 555-563.
30. Eichenbaum H,. How does the brain organize memories? Science 1997; 277: 330-332. (Pubitemid 27450697)
31. Allami N, et al,. Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice. Eur J Pharmacol 2011; 650: 240-248.