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Volumn 158, Issue 1-2, 2012, Pages 69-81

Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model

Author keywords

Coinfection; Interaction; Porcine circovirus type 2 (PCV2); Porcine reproductive and respiratory syndrome virus (PRRSV)

Indexed keywords

ARTERIVIRUS ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS DNA; VIRUS RNA;

EID: 84862783318     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2012.02.010     Document Type: Article
Times cited : (24)

References (63)
  • 2
    • 0034517938 scopus 로고    scopus 로고
    • Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication
    • Allan G.M., McNeilly F., Ellis J., Krakowka S., Meehan B., McNair I., Walker I., Kennedy S. Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication. Arch. Virol. 2000, 145:2421-2429.
    • (2000) Arch. Virol. , vol.145 , pp. 2421-2429
    • Allan, G.M.1    McNeilly, F.2    Ellis, J.3    Krakowka, S.4    Meehan, B.5    McNair, I.6    Walker, I.7    Kennedy, S.8
  • 4
    • 78649696450 scopus 로고    scopus 로고
    • Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtypes in pigs
    • Beach N.M., Ramamoorthy S., Opriessnig T., Wu S.Q., Meng X.J. Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtypes in pigs. Vaccine 2010, 29:221-232.
    • (2010) Vaccine , vol.29 , pp. 221-232
    • Beach, N.M.1    Ramamoorthy, S.2    Opriessnig, T.3    Wu, S.Q.4    Meng, X.J.5
  • 5
    • 14044274588 scopus 로고    scopus 로고
    • A review of porcine circovirus 2-associated syndromes and diseases
    • Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Vet. J. 2005, 169:326-336.
    • (2005) Vet. J. , vol.169 , pp. 326-336
    • Chae, C.1
  • 7
    • 33846215597 scopus 로고    scopus 로고
    • Epidemiologic assessment of porcine circovirus type 2 coinfection with other pathogens in swine
    • Dorr P.M., Baker R.B., Almond G.W., Wayne S.R., Gebreyes W.A. Epidemiologic assessment of porcine circovirus type 2 coinfection with other pathogens in swine. J. Am. Vet. Med. Assoc. 2007, 230:244-250.
    • (2007) J. Am. Vet. Med. Assoc. , vol.230 , pp. 244-250
    • Dorr, P.M.1    Baker, R.B.2    Almond, G.W.3    Wayne, S.R.4    Gebreyes, W.A.5
  • 8
    • 0033629104 scopus 로고    scopus 로고
    • A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus
    • Drew T.W. A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus. Vet. Res. 2000, 31:27-39.
    • (2000) Vet. Res. , vol.31 , pp. 27-39
    • Drew, T.W.1
  • 9
    • 34247464685 scopus 로고    scopus 로고
    • Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus: analysis of isolates collected between 1999 and 2004
    • Fang Y., Schneider P., Zhang W.P., Faaberg K.S., Nelson E.A., Rowland R.R. Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus: analysis of isolates collected between 1999 and 2004. Arch. Virol. 2007, 152:1009-1017.
    • (2007) Arch. Virol. , vol.152 , pp. 1009-1017
    • Fang, Y.1    Schneider, P.2    Zhang, W.P.3    Faaberg, K.S.4    Nelson, E.A.5    Rowland, R.R.6
  • 10
    • 0033944713 scopus 로고    scopus 로고
    • Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2
    • Fenaux M., Halbur P.G., Gill M., Toth T.E., Meng X.J. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. J. Clin. Microbiol. 2000, 38:2494-2503.
    • (2000) J. Clin. Microbiol. , vol.38 , pp. 2494-2503
    • Fenaux, M.1    Halbur, P.G.2    Gill, M.3    Toth, T.E.4    Meng, X.J.5
  • 11
    • 0035950603 scopus 로고    scopus 로고
    • A molecular clock dates the common ancestor of European-type porcine reproductive and respiratory syndrome virus at more than 10 years before the emergence of disease
    • Forsberg R., Oleksiewicz M.B., Petersen A.M., Hein J., Botner A., Storgaard T. A molecular clock dates the common ancestor of European-type porcine reproductive and respiratory syndrome virus at more than 10 years before the emergence of disease. Virology 2001, 289:174-179.
    • (2001) Virology , vol.289 , pp. 174-179
    • Forsberg, R.1    Oleksiewicz, M.B.2    Petersen, A.M.3    Hein, J.4    Botner, A.5    Storgaard, T.6
  • 12
    • 39149102499 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins
    • Fort M., Sibila M., Allepuz A., Mateu E., Roerink F., Segales J. Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins. Vaccine 2008, 26:1063-1071.
    • (2008) Vaccine , vol.26 , pp. 1063-1071
    • Fort, M.1    Sibila, M.2    Allepuz, A.3    Mateu, E.4    Roerink, F.5    Segales, J.6
  • 14
    • 84855587828 scopus 로고    scopus 로고
    • Genetic and phenotypic characterization of a 2006 United States porcine reproductive and respiratory virus isolate associated with high morbidity and mortality in the field
    • Gauger P., Faaberg K.S., Guo B., Kappes M.A., Opriessnig T. Genetic and phenotypic characterization of a 2006 United States porcine reproductive and respiratory virus isolate associated with high morbidity and mortality in the field. Virus Res. 2012, 163:98-107.
    • (2012) Virus Res. , vol.163 , pp. 98-107
    • Gauger, P.1    Faaberg, K.S.2    Guo, B.3    Kappes, M.A.4    Opriessnig, T.5
  • 15
    • 0029266676 scopus 로고
    • Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs
    • Halbur P.G., Miller L.D., Paul P.S., Meng X.J., Huffman E.L., Andrews J.J. Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs. Vet. Pathol. 1995, 32:200-204.
    • (1995) Vet. Pathol. , vol.32 , pp. 200-204
    • Halbur, P.G.1    Miller, L.D.2    Paul, P.S.3    Meng, X.J.4    Huffman, E.L.5    Andrews, J.J.6
  • 16
    • 0029397706 scopus 로고
    • Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus
    • Halbur P.G., Paul P.S., Frey M.L., Landgraf J., Eernisse K., Meng X.J., Lum M.A., Andrews J.J., Rathje J.A. Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 1995, 32:648-660.
    • (1995) Vet. Pathol. , vol.32 , pp. 648-660
    • Halbur, P.G.1    Paul, P.S.2    Frey, M.L.3    Landgraf, J.4    Eernisse, K.5    Meng, X.J.6    Lum, M.A.7    Andrews, J.J.8    Rathje, J.A.9
  • 17
    • 0029678766 scopus 로고    scopus 로고
    • Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model
    • Halbur P.G., Paul P.S., Meng X.J., Lum M.A., Andrews J.J., Rathje J.A. Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model. J. Vet. Diagn. Invest. 1996, 8:11-20.
    • (1996) J. Vet. Diagn. Invest. , vol.8 , pp. 11-20
    • Halbur, P.G.1    Paul, P.S.2    Meng, X.J.3    Lum, M.A.4    Andrews, J.J.5    Rathje, J.A.6
  • 19
    • 16344393530 scopus 로고    scopus 로고
    • The origin and evolution of porcine reproductive and respiratory syndrome viruses
    • Hanada K., Suzuki Y., Nakane T., Hirose O., Gojobori T. The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol. Biol. Evol. 2005, 22:1024-1031.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 1024-1031
    • Hanada, K.1    Suzuki, Y.2    Nakane, T.3    Hirose, O.4    Gojobori, T.5
  • 20
    • 0035995810 scopus 로고    scopus 로고
    • Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection
    • Harms P.A., Halbur P.G., Sorden S.D. Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection. J. Swine Health Prod. 2002, 10:27-30.
    • (2002) J. Swine Health Prod. , vol.10 , pp. 27-30
    • Harms, P.A.1    Halbur, P.G.2    Sorden, S.D.3
  • 21
    • 0035461746 scopus 로고    scopus 로고
    • Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus
    • Harms P.A., Sorden S.D., Halbur P.G., Bolin S.R., Lager K.M., Morozov I., Paul P.S. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus. Vet. Pathol. 2001, 38:528-539.
    • (2001) Vet. Pathol. , vol.38 , pp. 528-539
    • Harms, P.A.1    Sorden, S.D.2    Halbur, P.G.3    Bolin, S.R.4    Lager, K.M.5    Morozov, I.6    Paul, P.S.7
  • 22
    • 34548840862 scopus 로고    scopus 로고
    • A cluster of farms experiencing severe porcine circovirus associated disease: clinical features and association with the PCV2b genotype
    • Horlen K.P., Schneider P., Anderson J., Nietfeld J.C., Henry S.C., Tokach L.M., Rowland R.R. A cluster of farms experiencing severe porcine circovirus associated disease: clinical features and association with the PCV2b genotype. J. Swine Health Prod. 2007, 15:270-278.
    • (2007) J. Swine Health Prod. , vol.15 , pp. 270-278
    • Horlen, K.P.1    Schneider, P.2    Anderson, J.3    Nietfeld, J.C.4    Henry, S.C.5    Tokach, L.M.6    Rowland, R.R.7
  • 23
    • 7044253008 scopus 로고    scopus 로고
    • Pathogenic and humoral immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) are related to viral load in acute infection
    • Johnson W., Roof M., Vaughn E., Christopher-Hennings J., Johnson C.R., Murtaugh M.P. Pathogenic and humoral immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) are related to viral load in acute infection. Vet. Immunol. Immunopathol. 2004, 102:233-247.
    • (2004) Vet. Immunol. Immunopathol. , vol.102 , pp. 233-247
    • Johnson, W.1    Roof, M.2    Vaughn, E.3    Christopher-Hennings, J.4    Johnson, C.R.5    Murtaugh, M.P.6
  • 24
    • 70350470004 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections
    • Jung K., Renukaradhya G.J., Alekseev K.P., Fang Y., Tang Y., Saif L.J. Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections. J. Gen. Virol. 2009, 90:2713-2723.
    • (2009) J. Gen. Virol. , vol.90 , pp. 2713-2723
    • Jung, K.1    Renukaradhya, G.J.2    Alekseev, K.P.3    Fang, Y.4    Tang, Y.5    Saif, L.J.6
  • 25
    • 0035229271 scopus 로고    scopus 로고
    • Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2)
    • Krakowka S., Ellis J.A., McNeilly F., Ringler S., Rings D.M., Allan G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet. Pathol. 2001, 38:31-42.
    • (2001) Vet. Pathol. , vol.38 , pp. 31-42
    • Krakowka, S.1    Ellis, J.A.2    McNeilly, F.3    Ringler, S.4    Rings, D.M.5    Allan, G.6
  • 26
    • 34948845594 scopus 로고    scopus 로고
    • Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones
    • Lager K.M., Gauger P.C., Vincent A.L., Opriessnig T., Kehrli M.E., Cheung A.K. Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Vet. Rec. 2007, 161:428-429.
    • (2007) Vet. Rec. , vol.161 , pp. 428-429
    • Lager, K.M.1    Gauger, P.C.2    Vincent, A.L.3    Opriessnig, T.4    Kehrli, M.E.5    Cheung, A.K.6
  • 27
    • 52649180971 scopus 로고    scopus 로고
    • An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome
    • Lv J., Zhang J., Sun Z., Liu W., Yuan S. An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome. J. Gen. Virol. 2008, 89:2075-2079.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2075-2079
    • Lv, J.1    Zhang, J.2    Sun, Z.3    Liu, W.4    Yuan, S.5
  • 29
    • 0028298315 scopus 로고
    • Molecular cloning and nucleotide sequencing of the 3'-terminal genomic RNA of the porcine reproductive and respiratory syndrome virus
    • Meng X.J., Paul P.S., Halbur P.G. Molecular cloning and nucleotide sequencing of the 3'-terminal genomic RNA of the porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 1994, 75:1795-1801.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1795-1801
    • Meng, X.J.1    Paul, P.S.2    Halbur, P.G.3
  • 30
    • 0030180141 scopus 로고    scopus 로고
    • Characterization of a high-virulence US isolate of porcine reproductive and respiratory syndrome virus in a continuous cell line, ATCC CRL11171
    • Meng X.J., Paul P.S., Halbur P.G., Lum M.A. Characterization of a high-virulence US isolate of porcine reproductive and respiratory syndrome virus in a continuous cell line, ATCC CRL11171. J. Vet. Diagn. Invest. 1996, 8:374-381.
    • (1996) J. Vet. Diagn. Invest. , vol.8 , pp. 374-381
    • Meng, X.J.1    Paul, P.S.2    Halbur, P.G.3    Lum, M.A.4
  • 31
    • 0023990260 scopus 로고
    • Size and antigenic comparisons among the structural proteins of selected autonomous parvoviruses
    • Mengeling W.L., Ridpath J.F., Vorwald A.C. Size and antigenic comparisons among the structural proteins of selected autonomous parvoviruses. J. Gen. Virol. 1988, 69:825-837.
    • (1988) J. Gen. Virol. , vol.69 , pp. 825-837
    • Mengeling, W.L.1    Ridpath, J.F.2    Vorwald, A.C.3
  • 32
    • 0036149676 scopus 로고    scopus 로고
    • Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based enzyme-linked immunosorbent assays for detection of antibodies to PCV
    • Nawagitgul P., Harms P.A., Morozov I., Thacker B.J., Sorden S.D., Lekcharoensuk C., Paul P.S. Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based enzyme-linked immunosorbent assays for detection of antibodies to PCV. Clin. Diagn. Lab. Immunol. 2002, 9:33-40.
    • (2002) Clin. Diagn. Lab. Immunol. , vol.9 , pp. 33-40
    • Nawagitgul, P.1    Harms, P.A.2    Morozov, I.3    Thacker, B.J.4    Sorden, S.D.5    Lekcharoensuk, C.6    Paul, P.S.7
  • 33
    • 0032889516 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents
    • Nelsen C.J., Murtaugh M.P., Faaberg K.S. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J. Virol. 1999, 73:270-280.
    • (1999) J. Virol. , vol.73 , pp. 270-280
    • Nelsen, C.J.1    Murtaugh, M.P.2    Faaberg, K.S.3
  • 34
    • 0036889136 scopus 로고    scopus 로고
    • Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Ingelvac PRRS MLV), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV
    • Opriessnig T., Halbur P.G., Yoon K.J., Pogranichniy R.M., Harmon K.M., Evans R., Key K.F., Pallares F.J., Thomas P., Meng X.J. Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Ingelvac PRRS MLV), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV. J. Virol. 2002, 76:11837-11844.
    • (2002) J. Virol. , vol.76 , pp. 11837-11844
    • Opriessnig, T.1    Halbur, P.G.2    Yoon, K.J.3    Pogranichniy, R.M.4    Harmon, K.M.5    Evans, R.6    Key, K.F.7    Pallares, F.J.8    Thomas, P.9    Meng, X.J.10
  • 35
    • 32944479079 scopus 로고    scopus 로고
    • Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2
    • Opriessnig T., Halbur P.G., Yu S., Thacker E.L., Fenaux M., Meng X.J. Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2. Vet. Rec. 2006, 158:149-154.
    • (2006) Vet. Rec. , vol.158 , pp. 149-154
    • Opriessnig, T.1    Halbur, P.G.2    Yu, S.3    Thacker, E.L.4    Fenaux, M.5    Meng, X.J.6
  • 36
    • 42049113242 scopus 로고    scopus 로고
    • Influence of maternal antibodies on efficacy of porcine circovirus type 2 (PCV2) vaccination to protect pigs from experimental infection with PCV2
    • Opriessnig T., Patterson A.R., Elsener J., Meng X.J., Halbur P.G. Influence of maternal antibodies on efficacy of porcine circovirus type 2 (PCV2) vaccination to protect pigs from experimental infection with PCV2. Clin. Vaccine Immunol. 2008, 15:397-401.
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 397-401
    • Opriessnig, T.1    Patterson, A.R.2    Elsener, J.3    Meng, X.J.4    Halbur, P.G.5
  • 37
    • 84864810034 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2)-infection and re-inoculation with homologous or heterologous strains: virological, serological, pathological and clinical effects in growing pigs
    • Opriessnig T., Prickett J.R., Madson D.M., Shen H.-G., Juhan N.M., Pogranichniy R.R., Meng X.-J., Halbur P.G. Porcine circovirus type 2 (PCV2)-infection and re-inoculation with homologous or heterologous strains: virological, serological, pathological and clinical effects in growing pigs. Vet. Res. 2010, 41:31.
    • (2010) Vet. Res. , vol.41 , pp. 31
    • Opriessnig, T.1    Prickett, J.R.2    Madson, D.M.3    Shen, H.-G.4    Juhan, N.M.5    Pogranichniy, R.R.6    Meng, X.-J.7    Halbur, P.G.8
  • 38
    • 54449084635 scopus 로고    scopus 로고
    • Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection
    • Opriessnig T., Ramamoorthy S., Madson D.M., Patterson A.R., Pal N., Carman S., Meng X.J., Halbur P.G. Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. J. Gen. Virol. 2008, 89:2482-2491.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2482-2491
    • Opriessnig, T.1    Ramamoorthy, S.2    Madson, D.M.3    Patterson, A.R.4    Pal, N.5    Carman, S.6    Meng, X.J.7    Halbur, P.G.8
  • 39
    • 9644287992 scopus 로고    scopus 로고
    • Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2
    • Opriessnig T., Thacker E.L., Yu S., Fenaux M., Meng X.J., Halbur P.G. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Vet. Pathol. 2004, 41:624-640.
    • (2004) Vet. Pathol. , vol.41 , pp. 624-640
    • Opriessnig, T.1    Thacker, E.L.2    Yu, S.3    Fenaux, M.4    Meng, X.J.5    Halbur, P.G.6
  • 41
    • 3242674572 scopus 로고    scopus 로고
    • Derivation of porcine circovirus type 2-negative pigs from positive breeding herds
    • Opriessnig T., Yu S., Thacker E., Halbur P.G. Derivation of porcine circovirus type 2-negative pigs from positive breeding herds. J. Swine Health Prod. 2004, 12:186-191.
    • (2004) J. Swine Health Prod. , vol.12 , pp. 186-191
    • Opriessnig, T.1    Yu, S.2    Thacker, E.3    Halbur, P.G.4
  • 43
    • 79952688735 scopus 로고    scopus 로고
    • Epidemiology and horizontal transmission of porcine circovirus type 2 (PCV2)
    • Patterson A.R., Opriessnig T. Epidemiology and horizontal transmission of porcine circovirus type 2 (PCV2). Anim. Health Res. Rev. 2010, 11:217-234.
    • (2010) Anim. Health Res. Rev. , vol.11 , pp. 217-234
    • Patterson, A.R.1    Opriessnig, T.2
  • 44
    • 0032113078 scopus 로고    scopus 로고
    • Genomic and antigenic variations of porcine reproductive and respiratory syndrome virus major envelope GP5 glycoprotein
    • Pirzadeh B., Gagnon C.A., Dea S. Genomic and antigenic variations of porcine reproductive and respiratory syndrome virus major envelope GP5 glycoprotein. Can. J. Vet. Res. 1998, 62:170-177.
    • (1998) Can. J. Vet. Res. , vol.62 , pp. 170-177
    • Pirzadeh, B.1    Gagnon, C.A.2    Dea, S.3
  • 45
    • 77957727737 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs
    • Renukaradhya G.J., Alekseev K., Jung K., Fang Y., Saif L.J. Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs. Viral Immunol. 2010, 23:457-466.
    • (2010) Viral Immunol. , vol.23 , pp. 457-466
    • Renukaradhya, G.J.1    Alekseev, K.2    Jung, K.3    Fang, Y.4    Saif, L.J.5
  • 47
  • 48
    • 0033526855 scopus 로고    scopus 로고
    • The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332
    • Rowland R.R., Steffen M., Ackerman T., Benfield D.A. The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332. Virology 1999, 259:262-266.
    • (1999) Virology , vol.259 , pp. 262-266
    • Rowland, R.R.1    Steffen, M.2    Ackerman, T.3    Benfield, D.A.4
  • 49
    • 0037329988 scopus 로고    scopus 로고
    • Experimental dual infection of specific pathogen-free pigs with porcine reproductive and respiratory syndrome virus and pseudorabies virus
    • Shibata I., Yazawa S., Ono M., Okuda Y. Experimental dual infection of specific pathogen-free pigs with porcine reproductive and respiratory syndrome virus and pseudorabies virus. J. Vet. Med. B: Infect. Dis. Vet. Public Health 2003, 50:14-19.
    • (2003) J. Vet. Med. B: Infect. Dis. Vet. Public Health , vol.50 , pp. 14-19
    • Shibata, I.1    Yazawa, S.2    Ono, M.3    Okuda, Y.4
  • 50
    • 80051826383 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding
    • Sinha A., Shen H.G., Schalk S., Beach N.M., Huang Y.W., Meng X.J., Halbur P.G., Opriessnig T. Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Vet. Microbiol. 2011, 152:235-246.
    • (2011) Vet. Microbiol. , vol.152 , pp. 235-246
    • Sinha, A.1    Shen, H.G.2    Schalk, S.3    Beach, N.M.4    Huang, Y.W.5    Meng, X.J.6    Halbur, P.G.7    Opriessnig, T.8
  • 51
    • 0000996468 scopus 로고    scopus 로고
    • Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue
    • Sorden S.D., Harms P.A., Nawagitgul P., Cavanaugh D., Paul P.S. Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue. J. Vet. Diagn. Invest. 1999, 11:528-530.
    • (1999) J. Vet. Diagn. Invest. , vol.11 , pp. 528-530
    • Sorden, S.D.1    Harms, P.A.2    Nawagitgul, P.3    Cavanaugh, D.4    Paul, P.S.5
  • 54
    • 0034153670 scopus 로고    scopus 로고
    • Proinflammatory cytokines and viral respiratory disease in pigs
    • Van Reeth K., Nauwynck H. Proinflammatory cytokines and viral respiratory disease in pigs. Vet. Res. 2000, 31:187-213.
    • (2000) Vet. Res. , vol.31 , pp. 187-213
    • Van Reeth, K.1    Nauwynck, H.2
  • 55
    • 0029873804 scopus 로고    scopus 로고
    • Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study
    • Van Reeth K., Nauwynck H., Pensaert M. Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study. Vet. Microbiol. 1996, 48:325-335.
    • (1996) Vet. Microbiol. , vol.48 , pp. 325-335
    • Van Reeth, K.1    Nauwynck, H.2    Pensaert, M.3
  • 56
    • 38649113555 scopus 로고    scopus 로고
    • Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence
    • Wang Y., Liang Y., Han J., Burkhart K.M., Vaughn E.M., Roof M.B., Faaberg K.S. Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence. Virology 2008, 371:418-429.
    • (2008) Virology , vol.371 , pp. 418-429
    • Wang, Y.1    Liang, Y.2    Han, J.3    Burkhart, K.M.4    Vaughn, E.M.5    Roof, M.B.6    Faaberg, K.S.7
  • 57
    • 70350389128 scopus 로고    scopus 로고
    • Genetic variation and pathogenicity of highly virulent porcine reproductive and respiratory syndrome virus emerging in China
    • Wu J., Li J., Tian F., Ren S., Yu M., Chen J., Lan Z., Zhang X., Yoo D., Wang J. Genetic variation and pathogenicity of highly virulent porcine reproductive and respiratory syndrome virus emerging in China. Arch. Virol. 2009, 154:1589-1597.
    • (2009) Arch. Virol. , vol.154 , pp. 1589-1597
    • Wu, J.1    Li, J.2    Tian, F.3    Ren, S.4    Yu, M.5    Chen, J.6    Lan, Z.7    Zhang, X.8    Yoo, D.9    Wang, J.10
  • 58
    • 33846238203 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs
    • Yu S., Opriessnig T., Kitikoon P., Nilubol D., Halbur P.G., Thacker E. Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs. Vet. Immunol. Immunopathol. 2007, 115:261-272.
    • (2007) Vet. Immunol. Immunopathol. , vol.115 , pp. 261-272
    • Yu, S.1    Opriessnig, T.2    Kitikoon, P.3    Nilubol, D.4    Halbur, P.G.5    Thacker, E.6
  • 59
    • 0035814019 scopus 로고    scopus 로고
    • Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains
    • Yuan S., Mickelson D., Murtaugh M.P., Faaberg K.S. Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains. Virus Res. 2001, 79:189-200.
    • (2001) Virus Res. , vol.79 , pp. 189-200
    • Yuan, S.1    Mickelson, D.2    Murtaugh, M.P.3    Faaberg, K.S.4
  • 60
    • 0034665220 scopus 로고    scopus 로고
    • Heteroclite subgenomic RNAs are produced in porcine reproductive and respiratory syndrome virus infection
    • Yuan S., Murtaugh M.P., Faaberg K.S. Heteroclite subgenomic RNAs are produced in porcine reproductive and respiratory syndrome virus infection. Virology 2000, 275:158-169.
    • (2000) Virology , vol.275 , pp. 158-169
    • Yuan, S.1    Murtaugh, M.P.2    Faaberg, K.S.3
  • 61
    • 8444241086 scopus 로고    scopus 로고
    • Characterization of heteroclite subgenomic RNAs associated with PRRSV infection
    • Yuan S., Murtaugh M.P., Schumann F.A., Mickelson D., Faaberg K.S. Characterization of heteroclite subgenomic RNAs associated with PRRSV infection. Virus Res. 2004, 105:75-87.
    • (2004) Virus Res. , vol.105 , pp. 75-87
    • Yuan, S.1    Murtaugh, M.P.2    Schumann, F.A.3    Mickelson, D.4    Faaberg, K.S.5
  • 62
    • 0033063134 scopus 로고    scopus 로고
    • Recombination between North American strains of porcine reproductive and respiratory syndrome virus
    • Yuan S., Nelsen C.J., Murtaugh M.P., Schmitt B.J., Faaberg K.S. Recombination between North American strains of porcine reproductive and respiratory syndrome virus. Virus Res. 1999, 61:87-98.
    • (1999) Virus Res. , vol.61 , pp. 87-98
    • Yuan, S.1    Nelsen, C.J.2    Murtaugh, M.P.3    Schmitt, B.J.4    Faaberg, K.S.5
  • 63
    • 65349102181 scopus 로고    scopus 로고
    • The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence
    • Zhou L., Zhang J., Zeng J., Yin S., Li Y., Zheng L., Guo X., Ge X., Yang H. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. J. Virol. 2009, 83:5156-5167.
    • (2009) J. Virol. , vol.83 , pp. 5156-5167
    • Zhou, L.1    Zhang, J.2    Zeng, J.3    Yin, S.4    Li, Y.5    Zheng, L.6    Guo, X.7    Ge, X.8    Yang, H.9


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