Genetic and phenotypic characterization of a 2006 United States porcine reproductive and respiratory virus isolate associated with high morbidity and mortality in the field

Virus Research

Volumn 163, Issue 1, 2012, Pages 98-107

  Gauger, Phillip C ^a   Faaberg, Kay S ^b   Guo, Baoqing ^a   Kappes, Matthew A ^b   Opriessnig, Tanja ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

In vitro characterization; Porcine reproductive and respiratory syndrome virus (PRRSV); Sequencing

Indexed keywords

NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 2; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID ANALYSIS; ARTERIVIRUS; ARTICLE; DISEASE ASSOCIATION; GENE DELETION; GENE SEQUENCE; GENOME ANALYSIS; GENOTYPE PHENOTYPE CORRELATION; INOCULATION; MORBIDITY; MORTALITY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; UNINDEXED SEQUENCE; UNITED STATES; VIROGENESIS; VIRUS GENE; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CLUSTER ANALYSIS; GENOME, VIRAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; PHYLOGENY; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SWINE; UNITED STATES; VIRAL LOAD; VIRAL PLAQUE ASSAY; VIRUS REPLICATION;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 84855587828     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2011.08.017     Document Type: Article

References (41)

1. Allende R., Lewis T.L., Lu Z., Rock D.L., Kutish G.F., Ali A., Doster A.R., Osorio F.A. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J. Gen. Virol. 1999, 80:307-315.
2. Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch. Virol. 1997, 142:629-633.
3. Cho J.G., Dee S.A. Porcine reproductive and respiratory syndrome virus. Theriogenology 2006, 66:655-662.
4. Christianson W.T., Collins J.E., Benfield D.A., Harris L., Gorcyca D.E., Chladek D.W., Morrison R.B., Joo H.S. Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows. Am. J. Vet. Res. 1992, 53:485-488.
5. Collins J.E., Benfield D.A., Christianson W.T., Harris L., Hennings J.C., Shaw D.P., Goyal S.M., McCullough S., Morrison R.B., Joo H.S., Gorcyca D., Chladek D. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J. Vet. Diagn. Invest. 1992, 4:117-126.
6. Dewey C., Charbonneau G., Carman S., Hamel A., Nayar G., Friendship R., Eernisse K., Swenson S. Lelystad-like strain of porcine reproductive and respiratory syndrome virus (PRRSV) identified in Canadian swine. Can. Vet. J. 2000, 41:493-494.
7. Fang Y., Kim D.Y., Ropp S., Steen P., Christopher-Hennings J., Nelson E.A., Rowland R.R. Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Virus Res. 2004, 100:229-235.
8. Forsberg R., Oleksiewicz M.B., Petersen A.M., Hein J., Botner A., Storgaard T. A molecular clock dates the common ancestor of European-type porcine reproductive and respiratory syndrome virus at more than 10 years before the emergence of disease. Virology 2001, 289:174-179.
9. Forsberg R., Storgaard T., Nielsen H.S., Oleksiewicz M.B., Cordioli P., Sala G., Hein J., Botner A. The genetic diversity of European type PRRSV is similar to that of the North American type but is geographically skewed within Europe. Virology 2002, 299:38-47.
10. Guo, B., Vorwald, A.C., Alt, D.P., Lager, K.M., Bayles, D.O., Faaberg, K.S., 2011. Large scale parallel pyrosequencing technology: PRRSV strain VR-2332 nsp2 deletion mutant stability in swine. Virus Res., doi:10.1016/j.virusres.2011.07.018.
11. Halbur P.G., Paul P.S., Frey M.L., Landgraf J., Eernisse K., Meng X.J., Lum M.A., Andrews J.J., Rathje J.A. Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 1995, 32:648-660.
12. Halbur P.G., Paul P.S., Meng X.J., Lum M.A., Andrews J.J., Rathje J.A. Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model. J. Vet. Diagn. Invest. 1996, 8:11-20.
13. Han J., Liu G., Wang Y., Faaberg K.S. Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture. J. Virol. 2007, 81:9878-9890.
14. Han J., Wang Y., Faaberg K.S. Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res. 2006, 122:175-182.
15. Hanada K., Suzuki Y., Nakane T., Hirose O., Gojobori T. The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol. Biol. Evol. 2005, 22:1024-1031.
16. Keffaber K.K. Reproductive failure of unknown etiology. Am. Assoc. Swine Pract. Newsl. 1989, 1:1-9.
17. Kimman T.G., Cornelissen L.A., Moormann R.J., Rebel J.M., Stockhofe-Zurwieden N. Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 2009, 27:3704-3718.
18. Li Y., Wang X., Bo K., Wang X., Tang B., Yang B., Jiang W., Jiang P. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Vet. J. 2007, 174:577-584.
19. Meng X.J., Paul P.S., Halbur P.G. Molecular cloning and nucleotide sequencing of the 3'-terminal genomic RNA of the porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 1994, 75:1795-1801.
20. Mengeling W.L., Lager K.M., Vorwald A.C. Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of " atypical" PRRS. Am. J. Vet. Res. 1998, 59:1540-1544.
21. Metwally S., Mohamed F., Faaberg K., Burrage T., Prarat M., Moran K., Bracht A., Mayr G., Berninger M., Koster L., To T.L., Nguyen V.L., Reising M., Landgraf J., Cox L., Lubroth J., Carrillo C. Pathogenicity and molecular characterization of emerging porcine reproductive and respiratory syndrome virus in Vietnam in 2007. Transbound. Emerg. Dis. 2010, 57:315-329.
22. Murtaugh M.P., Stadejek T., Abrahante J.E., Lam T.T., Leung F.C. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res. 2010, 154:18-30.
23. Nelsen C.J., Murtaugh M.P., Faaberg K.S. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J. Virol. 1999, 73:270-280.
24. Neumann E.J., Kliebenstein J.B., Johnson C.D., Mabry J.W., Bush E.J., Seitzinger A.H., Green A.L., Zimmerman J.J. Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J. Am. Vet. Med. Assoc. 2005, 227:385-392.
25. Paton D.J., Brown I.H., Edwards S., Wensvoort G. 'Blue ear' disease of pigs. Vet. Rec. 1991, 128:617.
26. Pirzadeh B., Gagnon C.A., Dea S. Genomic and antigenic variations of porcine reproductive and respiratory syndrome virus major envelope GP5 glycoprotein. Can. J. Vet. Res. 1998, 62:170-177.
27. Ramakrishnan M.A., Tu Z.J., Singh S., Chockalingam A.K., Gramer M.R., Wang P., Goyal S.M., Yang M., Halvorson D.A., Sreevatsan S. The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies. PLoS One 2009, 4:e7105.
28. Ropp S.L., Wees C.E., Fang Y., Nelson E.A., Rossow K.D., Bien M., Arndt B., Preszler S., Steen P., Christopher-Hennings J., Collins J.E., Benfield D.A., Faaberg K.S. Characterization of emerging European-like porcine reproductive and respiratory syndrome virus isolates in the United States. J. Virol. 2004, 78:3684-3703.
29. Rowland R.R., Steffen M., Ackerman T., Benfield D.A. The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332. Virology 1999, 259:262-266.
30. Shi M., Lam T.T., Hon C.C., Hui R.K., Faaberg K.S., Wennblom T., Murtaugh M.P., Stadejek T., Leung F.C. Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res. 2010, 154:7-17.
31. Tian K., Yu X., Zhao T., Feng Y., Cao Z., Wang C., Hu Y., Chen X., Hu D., Tian X., Liu D., Zhang S., Deng X., Ding Y., Yang L., Zhang Y., Xiao H., Qiao M., Wang B., Hou L., Wang X., Yang X., Kang L., Sun M., Jin P., Wang S., Kitamura Y., Yan J., Gao G.F. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2007, 2:e526.
32. Van Breedam W., Van Gorp H., Zhang J.Q., Crocker P.R., Delputte P.L., Nauwynck H.J. The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a silic acid-dependent manner. PLoS Pathog. 2010, 6:e1000730.
33. Wang Y., Liang Y., Han J., Burkhart K.M., Vaughn E.M., Roof M.B., Faaberg K.S. Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence. Virology 2008, 371:418-429.
34. Wensvoort G., Terpstra C., Pol J.M.A., Ter Laak E.A., Bloemraad M., De Kluyver E.P., Kragten C., Van Buiten L., Den Besten A., Wagenaar F., Broekhuijsen J.M., Moonen P.L.J.M., Zetstra T., De Boer E.A., Tibben H.J., De Jong M.F., Van't Veld P., Groenland G.J.R., Van Gennep J.A., Voets M.T.H., Verheijden J.H.M., Braamskamp J. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Q. 1991, 13:121-130.
35. Yang S.X., Kwang J., Laegreid W. Comparative sequence analysis of open reading frames 2-7 of the modified live vaccine virus and other North American isolates of the porcine reproductive and respiratory syndrome virus. Arch. Virol. 1998, 143:601-612.
36. Yoshii M., Okinaga T., Miyazaki A., Kato K., Ikeda H., Tsunemitsu H. Genetic polymorphism of the nsp2 gene in North American type - porcine reproductive and respiratory syndrome virus. Arch. Virol. 2008, 153:1323-1334.
37. Yuan S., Murtaugh M.P., Faaberg K.S. Heteroclite subgenomic RNAs are produced in porcine reproductive and respiratory syndrome virus infection. Virology 2000, 275:158-169.
38. Yuan S., Murtaugh M.P., Schumann F.A., Mickelson D., Faaberg K.S. Characterization of heteroclite subgenomic RNAs associated with PRRSV infection. Virus Res. 2004, 105:75-87.
39. Yuan S., Nelsen C.J., Murtaugh M.P., Schmitt B.J., Faaberg K.S. Recombination between North American strains of porcine reproductive and respiratory syndrome virus. Virus Res. 1999, 61:87-98.
40. Zhou L., Zhang J., Zeng J., Yin S., Li Y., Zheng L., Guo X., Ge X., Yang H. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. J. Virol. 2009, 83:5156-5167.
41. Zhou Y.J., Hao X.F., Tian Z.J., Tong G.Z., Yoo D., An T.Q., Zhou T., Li G.X., Qiu H.J., Wei T.C., Yuan X.F. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Transbound. Emerg. Dis. 2008, 55:152-164.