Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice

Journal of Clinical Neuroscience

Volumn 19, Issue 3, 2012, Pages 443-446

  Xu, Yaming ^a   Li, Xinyan ^b   Zhang, Shiyun ^a   Shen, Di ^a   Li, Hong ^a   Wu, Yue ^a   Qiu, Yongming ^c   Ji, Yonghua ^a   Chen, Fuxue ^a  

^a SHANGHAI UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Glioma; Nude mice; RNAi; Stat3; Survival

Indexed keywords

PROTEIN BCL 2; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GLIOMA CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RNA INTERFERENCE; TUMOR GROWTH;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENES, BCL-2; GLIOBLASTOMA; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PLASMIDS; RNA INTERFERENCE; STAT3 TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862782419     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2011.04.017     Document Type: Article

References (27)

1. J.E. Darnell Jr. STATs and gene regulation Science 277 1997 1630 1635
2. K. Takeda, B.E. Clausen, and T. Kaisho Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils Immunity 10 1999 39 49
3. G. Niu, K.L. Wright, and M. Huang Constitutive Stat3 activity up-regulates VEGF expression and tumour angiogenesis Oncogene 21 2002 2000 2008
4. Y. Aoki, G.M. Feldman, and G. Tosato Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma Blood 101 2003 1535 1542
5. T.N. Dechow, L. Pedranzini, and A. Leitch Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C Proc Natl Acad Sci USA 101 2004 10602 10607
6. M. Masuda, M. Suzui, and R. Yasumatu Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma Cancer Res 62 2002 3351 3355
7. J. Bromberg Stat proteins and oncogenesis J Clin Invest 109 2002 1139 1142
8. T. Bowman, R. Garcia, and J. Turkson STATs in oncogenesis Oncogene 19 2000 2474 2488
9. J.F. Bromberg, M.H. Wrzeszczynska, and G. Devgan Stat3 as an oncogene Cell 98 1999 295 303
10. R. Wechsler-Reya, and M.P. Scott The developmental biology of brain tumours Annu Rev Neurosci 24 2001 385 428
11. D.N. Louis, H. Ohgaki, and O.D. Wiestler The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 2007 97 109
12. P.Y. Wen, and S. Kesari Malignant gliomas in adults N Engl J Med 359 2008 492 507
13. H. Ohgaki, and P. Kleihues Epidemiology and etiology of gliomas Acta Neuropathol 109 2005 93 108
14. R. Stupp, W.P. Mason, and M.J. van den Bent Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 352 2005 987 996
15. W. Ren, Y. Duan, and Y. Yang Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer Neurol Res 30 2008 297 301
16. F. Chen, Y. Xu, and Y. Luo Down-regulation of Stat3 decreases invasion activity and induces apoptosis of human glioma cells J Mol Neurosci 40 2010 353 359
17. L. Konnikova, M. Kotecki, and M.M. Kruger Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells BMC Cancer 3 2003 23 32
18. J. Gu, G. Li, and T. Sun Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells J Neurooncol 89 2008 9 17
19. J. Sambrook, and D.W. Russell Molecular cloning: A laboratory manual 2001 Cold Spring Harbor Laboratory Press New York
20. T.J. Liu, M. Wang, and R.L. Breau Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines Cancer Gene Ther 6 1999 163 171
21. E. Fonsatti, L. Sigalotti, and P. Arslan Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies Curr Cancer Drug Targets 3 2003 427 432
22. Y. Yang, Y. Qiu, and W. Ren An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas Mol Carcinogen 47 2008 893 903
23. Y. Yang, W. Ren, and F. Chen Knockdown of Stat3 in C17.2 neural stem cells facilitates the generation of neurons: a possibility of transplantation with a low level of oncogene Neuroreport 17 2006 235 238
24. F. Zhou, Y. Yang, and D. Xing Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis FEBS J 278 2011 403 413
25. B.C. Yang, Y.S. Wang, and C.H. Wang Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2 Cell Biol Int 23 1999 533 540
26. A. Le Querrec, D. Duval, and G. Tobelem Tumour angiogenesis Baillieres Clin Haematol 6 1993 711 730
27. D. Wei, X. Le, and L. Zheng Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis Oncogene 22 2003 319 329